FR2576216A1

FR2576216A1 - Improved material and equipment for treating and destroying cancers

Info

Publication number: FR2576216A1
Application number: FR8410115A
Authority: FR
Inventors: Roger Remy; Louis Richard
Original assignee: Individual
Current assignee: Individual
Priority date: 1984-06-27
Filing date: 1984-06-27
Publication date: 1986-07-25

Abstract

The invention relates to improved material and equipment for treating and destroying cancers, characterised in that there is combined with a conventional so-called "transcutaneous radiotherapy" material, advantageously constituted by COBALT-60, means and methods for simultaneous interaction, on the one hand with a "hyperthermia" limited to approximately 42.5 DEG in the cancer cells and on the other hand, conversely, with a cooling of their periphery, so as to "confine" indirectly therein a local "overheating" and thus to quadruple the effectiveness of the radiotherapy, or to reduce by the same amount the "dosage" flow rate and therefore the risks otherwise inherent in the use of ionising radiation.

Description

L'invention vise à réaliser, des matériels perfectionnés et très "performants", de traitement et de destruction des cancers et d'abord, de ceux préablement "isolés et localîss", alors caractérisés par le fait, qu'ils quadruplent l'efficacité, de ceux antérieurement connus, dits de "radiothérapie transcutanée" et généralement désignés "bombes au cobalt", en y inté- grant, ou en y juxtaposant - selon qu'il s'agit de matériels d'irradiation neufs ou anciens - des moyens et procédés dits .'d'hyperthermie" connus, mais interagissant alors et en outre, originalement et inversement, avec d'autres dits de refroidissement de la périph4rie, des dits cancers, tout en ouvrant ainsi et du ment coup,- des possibilités de traitement, des cancers dits "gé- néralisés. The invention aims to produce, sophisticated and very "efficient" materials, for the treatment and destruction of cancers and, first of all, those previously "isolated and localized", then characterized by the fact that they quadruple the effectiveness , of those previously known, called "transcutaneous radiotherapy" and generally designated "cobalt bombs", by integrating therein, or by juxtaposing them - depending on whether they are new or old irradiation materials - means and so-called "hyperthermia" methods known, but interacting then and in addition, originally and vice versa, with other so-called periphery cooling, so-called cancers, while thus opening up and suddenly, - possibilities for treatment, so-called "generalized" cancers.

On comprendra mieux ces caractiristiques nouvelles, ainsi que d'autres qui s'y rattachent et les avantages de l'invention, en se reportant à la description suivante, qui expose un mode de mise en oeuvre avantageux, mais non limitatif, dans lequel:
Conformément à l'invention, on combine à un matériel usuel, dit de "Téléradiothérapie transcutanée par le "COBALT 60", produisant donc un rayonnement dit "gamma", de haute énergie et convenablement "focalisable", dans un environnement, conçu pour "cibler" le corps du rasade, par rapport & la "source" de ce rayonnement, mais qui est originalement appropriée à Sa fonction, sinon nouvelle, du moins maintenant considérablement réduite, par une réduction de son "débit de dose", de l'ordre de la moitié et donc à environ 50 rads par minute, au niveau du cancer ainsi traité, tout en pouvant être réduit; jusqu'à environ 25 rads par minute, ce qui réduit d'autant les risques, sinon inhérents, à l'utilisation des rayonnements ionisants usuels.These new features will be better understood, as well as others which are attached thereto and the advantages of the invention, by referring to the following description, which sets out an advantageous, but non-limiting, mode of implementation in which:
In accordance with the invention, a standard equipment, known as "Transcutaneous teleradiotherapy with the" COBALT 60 ", is combined with a so-called" gamma "radiation, of high energy and suitably" focusing ", in an environment designed for" target "the body of the drink, in relation to the" source "of this radiation, but which is originally appropriate to its function, if not new, at least now considerably reduced, by a reduction in its" dose rate ", of the order of half and therefore at approximately 50 rads per minute, at the level of the cancer thus treated, while being able to be reduced; up to approximately 25 rads per minute, which correspondingly reduces the risks, if not inherent, in the use of usual ionizing radiation.

Un tel matdriel, bien que d'un "débit de dose" de son irradiation, ainsi très réduit, demeure néanmoins très performant et qu'il soit de fabrication nouvelle ou ancienne, et alors respectivement, soit en y incorporant, ou en y juxtaposant - avantageusement dans la région du "pupitre de commande", des moyens et procédés déjà connus, pour engendrer, guider ou "focaliser", un apport de chaleur approprié et avantageusement concentré sur le cancer et par exemple, par micro-ondes des diverses fréquences utilisables et compatibles, avec une "application par électrodes implantables", mais en outre perfectionnées, pour être "électro-coagulantes", selon le processus connu, pour les bistouris de cette nature, de façon à en permettre une implantation, sans risque de "migration" de cellules cancéreuses, dans la région centrale du cancer à traiter et y produire ainsi, une "surchauffe" bien localisée et pré- déterminée expérimentalement, de façon à ne pas dépasser une température d' environ 420,5 et être évacuée au delà de ce seuil automatiquement, et très préférentiellement, à sa périphèrie, par la circulation sanguine, ainsi que c'est exposé, plus loin. Such a material, although of a "dose rate" of its irradiation, thus very reduced, remains nevertheless very efficient and whether it is of new or old manufacture, and then respectively, either by incorporating therein, or by juxtaposing therein - advantageously in the region of the "control console", means and methods already known, for generating, guiding or "focusing", an appropriate heat supply and advantageously concentrated on cancer and for example, by microwaves of various frequencies usable and compatible, with an "application by implantable electrodes", but also improved, to be "electro-coagulating", according to the known process, for scalpels of this nature, so as to allow implantation thereof, without risk of " migration "of cancer cells, into the central region of the cancer to be treated and thus producing therein, a" localized "overheating" and predetermined experimentally, so as not to exceed a temperature of about 420.5 and be evacuated beyond this threshold automatically, and very preferably, at its periphery, by the blood circulation, as is explained below.

A cet égard, il convient de préciser, que le matériel ainsi perfectionné conformément à l'invention, interagit inversement et originalement, avec un matériel de réfrigération usuelle, de puissance convenablement appropriée et muni de ses accessoires, notaient d'asservissement de son "animation" habituelle, généralement réalisée par un "groupe moto-compresseur électrique dit hermétique", mais encore approprié à sa nouvelle fonction, d'induction d'un refroidissement à la circulation sanguine précitée, en ce que son "évapora- tueur. est mobile, selon le "plit Système" e" et qu'il est surtout et origina liement, d'une conformation en forme de "plastron pour former une enceinte thermiquement isolante, en outre élastiquement déformable et étanchable, contre une fraction du corps, du salade ainsi traité et qui en forme ainsi le "couvercle", pour évacuer hors de cette zone, la "surchauffe" collectée par la circulation sanguine et donc, très préférentiellement, dans la région surchauffée, de l'environnement du cancer, tandis que cette évacuation de chaleur sera ngligeable, dans le cancer, où cette circulation sanguine est de l'ordre de cinq fois plus faible. In this regard, it should be noted that the equipment thus perfected in accordance with the invention interacts inversely and originally, with conventional refrigeration equipment, of suitably suitable power and fitted with its accessories, noted as a servo for its "animation". "usual, generally carried out by an" electric hermetic motor-compressor group ", but still suitable for its new function, of inducing cooling to the aforementioned blood circulation, in that its" evaporator. is mobile, according to the "plit System" e "and that it is especially and origina liement, of a conformation in the form of" plastron to form a thermally insulating enclosure, in addition elastically deformable and watertight, against a fraction of the body, the salad as well treated and which thus forms the "cover", to evacuate from this zone, the "overheating" collected by the blood circulation and therefore, very preferably, in the overheated region, from the cancer environment, while this heat dissipation will be negligible, in cancer, where this blood circulation is on the order of five times lower.

Ainsi, au traitement "hyperthermique", auquel les cellules cancéreuses sont lègèrement plus sensible, que celles normales, il s'ajoutera surtout une efficacité sensiblement quadruplée de l'irradiation, par cette hyper- hermie, qui expêche la "réparation" des cellules cancéreuses, ayant subi des "dégâts dits non létaux, lors de l'irradiation. Thus, to the "hyperthermic" treatment, to which the cancer cells are slightly more sensitive than the normal ones, there will be added above all a substantially quadrupled efficacy of irradiation, by this hyperhermia, which prevents the "repair" of the cancer cells. , having suffered "so-called non-lethal damage, during irradiation.

an mentionnera encore, l'intérêt complémentaire, d'étendre la combinaison multiple précitée; à une "chimiothérapie" auxiliaire, alors avantageusement réalisée, par l'implantation d'un dispositif dit "micro doseurs, dont l'action locale est d'une toxicité réduite d'autant, mais suffisante, pour agir d'ailleurs préférentiellement, dans les onces zones "d'interfaces1, c'est-à-dire de transition, entre les cellules cancéreuses périphériques et celles encore saines, de leur environne est. an will also mention, the complementary interest, to extend the aforementioned multiple combination; an auxiliary "chemotherapy", then advantageously carried out, by the implantation of a device called "micro dosers, whose local action is of a toxicity reduced by as much, but sufficient, to act moreover preferentially, in the ounce zones "of interfaces1, that is to say of transition, between the peripheral cancer cells and those still healthy, of their environment is.

D'autre part, on mentionnera aussi, l'avantage, conforme à l'invention, de recouvrir les électrodes implantables, d'un rince film "anti-adhérent" et avantageusement, de polytétrafluoréthylène, pour en facililter l'enlèvement ultérieur. On the other hand, it will also be mentioned, the advantage, in accordance with the invention, of covering the implantable electrodes with a "non-stick" film rinse and advantageously, of polytetrafluoroethylene, to facilitate subsequent removal.

On mentionnera encore et surtout, que les matériels précités et ainsi per fectionnés, ouvrent originalement des perspectives de traitement des cancers les plus dangereux, dits "généralisés" et sans même en nécessiter de localisa- tions préalable, en ce que, selon les disposition6 précitées, c'est le simple "confinement" des surchauffes, qui étant très préférentiel dans les cellules cancéreuses, en combinaison avec leur refroidissement périphérique, délimite automatiquement et ainsi, des zones d'efficacité sensiblement quadruplée, à l'égard des rayonnements ionisants, émis à leur encontre. It will be mentioned again and above all, that the aforementioned materials and thus perfected, originally open up prospects for the treatment of the most dangerous cancers, known as "generalized" and without even requiring any prior locations, in that, according to the aforementioned provisions6 , it is the simple "confinement" of overheating, which being very preferential in cancer cells, in combination with their peripheral cooling, automatically delimits and thus, zones of efficiency substantially quadrupled, with regard to ionizing radiation, emitted against them.

En conséquence, le domaine de l'invention s'étend aux matériels appropriés en ce sens, en substituant alors à l'hyperthermie locale, de ceux précités, une hyperthermie généralisée quelconque, mais avantageusement et originalement réalisée, en enveloppant le corps du malade traité, dans une enceinte grillagée ou perforée et d'un "maillage" assez étroit, pour y retenir les micro-ondes, qui y sont convenablement réparties et entretenues, de fa çon connue et par exemple, par deux "guides d'ondes" latéraux, alimentés par des "magnétrons;;' tandis que ce maillage n'empêche pas la pénétration d'une irradiation ionisante, du genre précité, mais alors également généralisée, soit par une multiplication des "sources d'irradiation", ou par "défilement de l'irradiation, en bandes juxtaposées successives, ou encore par une combinaison de ces deux procédés, d'autant que c'est facilité, par l'abaissement du débit de dose de l'irradiation", jusqu'à environ 25 rads par minute au niveau moyen, tant des cellules cancéreuses à traiter, que de leurs "métastases."
Enfin, il est non seulement évident, mais explicitement ajouté, que le domaine de l'invention, ne se limite nullement, aux seules dispositions explicitement décrites, ou mêne simplement évoquées, mais qu'elle s'étend expressément, à toutes les variantes, tant d'exécution que d'application et notamment à celles mettant en oeuvre, des moyens et procédés équivalents ou simplement comparables et par exemple, par inversion ou transpositions des dispositions explicitement décrites.Consequently, the field of the invention extends to the appropriate materials in this sense, while substituting for local hyperthermia, from those mentioned above, any generalized hyperthermia of any kind, but advantageously and originally performed, by enveloping the body of the treated patient. , in a mesh or perforated enclosure and of a fairly narrow "mesh", to retain the microwaves, which are suitably distributed and maintained there, in known manner and for example, by two lateral "waveguides" , powered by "magnetrons ;; ' while this mesh does not prevent the penetration of ionizing irradiation, of the aforementioned kind, but then also generalized, either by a multiplication of "sources of irradiation", or by "scrolling of the irradiation, in successive juxtaposed bands , or even by a combination of these two methods, all the more that it is facilitated, by the lowering of the dose rate of the irradiation ", up to approximately 25 rads per minute at the average level, both for cancer cells to treat, than their "metastases."
Finally, it is not only obvious, but explicitly added, that the field of the invention is in no way limited to the only provisions explicitly described, or even simply mentioned, but that it expressly extends to all variants, both execution and application and in particular to those implementing, equivalent or simply comparable means and processes and for example, by inversion or transposition of the provisions explicitly described.

A titre d'exemples, de telles variantes, on mentionnera la possibilité de substituer à l'hyperthermie précitée, tous autres processus connus, soit par immersion dans un fluide chauffé ou par utilisation de combinaisons à circulation d'eau chaude, ou encore la convexion d'air chaud, ainsi que, le chauffage infra-rouge et l'irrigation par des fluides chauffés, sans oublier le chauffage "capacitif ou inductif haute fréquence", aussi bien que l'utilisation de courants HF ou d'un chauffage par "ultra-sons". By way of examples, such variants, mention may be made of the possibility of substituting for the aforementioned hyperthermia, all other known processes, either by immersion in a heated fluid or by the use of combinations with circulation of hot water, or even convection. of hot air, as well as, infrared heating and irrigation by heated fluids, without forgetting "capacitive or inductive high frequency" heating, as well as the use of HF currents or heating by " ultrasound ".

Claims

RH: vKNI) ICATIONS

I- Materials and equipment, of combined interaction, of improved means and processes, of treatment and destruction of "isolated and localized" cancers, characterized by the fact: that we combine, with a usual material, called "radiotherapy" transcutaneous ", advantageously by COBALT 60, means and methods of substantially simultaneous interaction, on the one hand with" hyperthermia ", limited to approximately 42-, 5 in cancer cells and on the other hand and conversely, with a cooling of their periphery, so as to indirectly "confine" there a local "overheating" and thus quadruple the effectiveness of radiotherapy, or to reduce by as much the so-called dose rate "and therefore the risks, if not inherent for the use of ionizing radiation.

2-- Materials and equipment, of combined interaction, according to claim I-, characterized by the fact: that the hyperthermia or overheating of the cancer treated, is preferably carried out, in its central region, by implanting electrodes, originally diathermic and non-stick, of local application of microwaves, in combination with a very preferential evacuation, of this overheating, beyond 42e, '; 5 beyond and at the periphery of the cancer, which is automatically carried out through the bloodstream, cooled accordingly.

3'- Materials and equipment, of combined interaction, according to claims I and 2, characterized by the fact: that the cooling of the blood circulation, is indirectly carried out, by a usual material called refrigeration, but suitable for its new function , by the implementation of a mobile "evaporator", in the form of a "front plate", thermally insulated and sealed, against a fraction of the patient's body, thus treated.

4-- Materials and equipment, of combined interaction, according to any one of claims I-, 2 'and 3, characterized by the fact: that they also interact, with a device called "microdiffusor" of "chemotherapy - thus, local and of low toxicity.

3- Materials and equipment, of combined interaction, of improved means and processes, of treatment and destruction of "generalized" cancers, characterized by the fact: that one combines, with a material of "transcutaneous radiotherapy", then suitable originally, to produce a generalized irradiation, or by successive juxtaposed sequences, a material of wsurheating "any known and also generalized, while being nevertheless, indirectly localized, in cancer cells and their" metastases ", by a material cooling, blood circulation, for example of the kind, according to claim 3-.

6th Materials and equipment, of combined interaction, according to claim OJ, characterized in that the generalized hyperthermia is originally produced, by enveloping the patient's body, in a substantially cylindrical enclosure and meshed or perforated, with a " mesh "close enough, to retain the" microwaves ", which are suitably distributed and maintained there, in a known manner, for example by two lateral" waveguides ", fed by" magnetrons "* while this "mesh" does not prevent the simultaneous penetration of ionizing irradiation, but then also generalized.

7th Materials and equipment, of combined interaction, according to claims 5 and 6, characterized by the fact: that they also interact with known and so-called "chemotherapy and" immunotherapy "auxiliary treatments.