FR2572074B1 - Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant - Google Patents

Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant

Info

Publication number
FR2572074B1
FR2572074B1 FR8415991A FR8415991A FR2572074B1 FR 2572074 B1 FR2572074 B1 FR 2572074B1 FR 8415991 A FR8415991 A FR 8415991A FR 8415991 A FR8415991 A FR 8415991A FR 2572074 B1 FR2572074 B1 FR 2572074B1
Authority
FR
France
Prior art keywords
group
pharmaceutical compositions
nervous system
central nervous
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8415991A
Other languages
English (en)
French (fr)
Other versions
FR2572074A1 (fr
Inventor
Camille Georges Wermuth
Roger Brodin
Paul Worms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR8415991A priority Critical patent/FR2572074B1/fr
Priority to AT85401972T priority patent/ATE50253T1/de
Priority to CA000492711A priority patent/CA1259990A/en
Priority to EP85401972A priority patent/EP0183577B1/fr
Priority to IL76652A priority patent/IL76652A0/xx
Priority to DE8585401972T priority patent/DE3575923D1/de
Priority to AU48480/85A priority patent/AU577159B2/en
Priority to US06/786,465 priority patent/US4596802A/en
Priority to DK469285A priority patent/DK469285A/da
Priority to JP60228991A priority patent/JPS6197274A/ja
Priority to PT81314A priority patent/PT81314B/pt
Priority to NZ213865A priority patent/NZ213865A/en
Priority to ES547962A priority patent/ES8605269A1/es
Priority to KR1019850007696A priority patent/KR860003245A/ko
Priority to ZA858030A priority patent/ZA858030B/xx
Priority to GR852530A priority patent/GR852530B/el
Publication of FR2572074A1 publication Critical patent/FR2572074A1/fr
Application granted granted Critical
Publication of FR2572074B1 publication Critical patent/FR2572074B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
FR8415991A 1984-10-18 1984-10-18 Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant Expired FR2572074B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR8415991A FR2572074B1 (fr) 1984-10-18 1984-10-18 Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant
AT85401972T ATE50253T1 (de) 1984-10-18 1985-10-10 Auf das zentralnervensystem wirksame thiadiazolderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
CA000492711A CA1259990A (en) 1984-10-18 1985-10-10 Process for the preparation of thiadiazole derivatives active on the central nervous system
EP85401972A EP0183577B1 (fr) 1984-10-18 1985-10-10 Dérivés du thiadiazole actifs sur le système nerveux central, procédé d'obtension et compositions pharmaceutiques les contenant
IL76652A IL76652A0 (en) 1984-10-18 1985-10-10 Thiadiazole derivatives,their preparation and pharmaceutical compositions containing them
DE8585401972T DE3575923D1 (de) 1984-10-18 1985-10-10 Auf das zentralnervensystem wirksame thiadiazolderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
AU48480/85A AU577159B2 (en) 1984-10-18 1985-10-10 Morpholinoethylamino-1,3,4-thiadiazole compounds
US06/786,465 US4596802A (en) 1984-10-18 1985-10-11 Thiadiazole derivatives active on the central nervous system and pharmaceutical compositions
DK469285A DK469285A (da) 1984-10-18 1985-10-14 Thiadiazolderivater, der indvirker paa centralnervesystemet, fremgangsmaade til fremstilling deraf og midler indeholdende derivaterne
JP60228991A JPS6197274A (ja) 1984-10-18 1985-10-16 中枢神経系に作用するチアジアゾール誘導体、その製造方法及びこの薬理上許容し得る塩
PT81314A PT81314B (pt) 1984-10-18 1985-10-16 Processo para a obtencao de derivados de tiadiazole activos sobre o sistema nervoso central
NZ213865A NZ213865A (en) 1984-10-18 1985-10-17 Derivatives of 2-(2-morpholinoethylamino)-1.3.4- thiadiazole and pharmaceutical compositions
ES547962A ES8605269A1 (es) 1984-10-18 1985-10-17 Procedimiento para la fabricacion de derivados de tiadiazol activos sobre el sistema nervioso central
KR1019850007696A KR860003245A (ko) 1984-10-18 1985-10-18 중추신경계에 특효가 있는 티아디아졸 유도체의 제조방법
ZA858030A ZA858030B (en) 1984-10-18 1985-10-18 Thiadiazole derivatives active on the central nervous system,process for their preparation and pharmaceutical compositions in which they are present
GR852530A GR852530B (US20040106767A1-20040603-C00005.png) 1984-10-18 1985-10-18

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8415991A FR2572074B1 (fr) 1984-10-18 1984-10-18 Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
FR2572074A1 FR2572074A1 (fr) 1986-04-25
FR2572074B1 true FR2572074B1 (fr) 1987-07-17

Family

ID=9308790

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8415991A Expired FR2572074B1 (fr) 1984-10-18 1984-10-18 Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant

Country Status (16)

Country Link
US (1) US4596802A (US20040106767A1-20040603-C00005.png)
EP (1) EP0183577B1 (US20040106767A1-20040603-C00005.png)
JP (1) JPS6197274A (US20040106767A1-20040603-C00005.png)
KR (1) KR860003245A (US20040106767A1-20040603-C00005.png)
AT (1) ATE50253T1 (US20040106767A1-20040603-C00005.png)
AU (1) AU577159B2 (US20040106767A1-20040603-C00005.png)
CA (1) CA1259990A (US20040106767A1-20040603-C00005.png)
DE (1) DE3575923D1 (US20040106767A1-20040603-C00005.png)
DK (1) DK469285A (US20040106767A1-20040603-C00005.png)
ES (1) ES8605269A1 (US20040106767A1-20040603-C00005.png)
FR (1) FR2572074B1 (US20040106767A1-20040603-C00005.png)
GR (1) GR852530B (US20040106767A1-20040603-C00005.png)
IL (1) IL76652A0 (US20040106767A1-20040603-C00005.png)
NZ (1) NZ213865A (US20040106767A1-20040603-C00005.png)
PT (1) PT81314B (US20040106767A1-20040603-C00005.png)
ZA (1) ZA858030B (US20040106767A1-20040603-C00005.png)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8625774D0 (en) * 1986-10-28 1986-12-03 Reckitt & Colmann Prod Ltd Thiadiazole derivative
FR2636628B1 (fr) * 1988-08-25 1990-12-28 Sanofi Sa Derives du thiadiazole-1,3,4, leur procede d'obtention et compositions pharmaceutiques en contenant
IT1255219B (it) * 1992-07-14 1995-10-20 Ct Lab Farm Srl Derivati del tiadiazolo per la cura degli stati depressivi
AU2005295441B2 (en) * 2004-10-18 2009-04-23 Amgen, Inc. Thiadiazole compounds and methods of use
WO2009011871A2 (en) * 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of pkb

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1053085A (US20040106767A1-20040603-C00005.png) * 1964-03-26
FR2092714B1 (US20040106767A1-20040603-C00005.png) * 1970-06-11 1974-03-22 Melle Bezons
US3919428A (en) * 1972-01-17 1975-11-11 Sandoz Ag 2-Amino-5-(substituted or unsubstituted phenylalkyl)1,3,4-thiadiazoles for treating anxiety

Also Published As

Publication number Publication date
KR860003245A (ko) 1986-05-21
AU4848085A (en) 1986-04-24
ZA858030B (en) 1986-06-25
AU577159B2 (en) 1988-09-15
IL76652A0 (en) 1986-02-28
DK469285D0 (da) 1985-10-14
PT81314A (fr) 1985-11-01
EP0183577A1 (fr) 1986-06-04
PT81314B (pt) 1987-11-30
CA1259990A (en) 1989-09-26
ATE50253T1 (de) 1990-02-15
FR2572074A1 (fr) 1986-04-25
ES547962A0 (es) 1986-03-16
NZ213865A (en) 1988-05-30
JPS6197274A (ja) 1986-05-15
GR852530B (US20040106767A1-20040603-C00005.png) 1986-02-19
DK469285A (da) 1986-04-19
US4596802A (en) 1986-06-24
DE3575923D1 (de) 1990-03-15
EP0183577B1 (fr) 1990-02-07
ES8605269A1 (es) 1986-03-16

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Legal Events

Date Code Title Description
ST Notification of lapse