FR2522282A1 - Zirconium oxide beads for absorption of phosphate(s) from blood - are coated with low mol. wt., permeable, hydrophilic polymer, pref. colloidion, and used to treat renal insufficient - Google Patents

Zirconium oxide beads for absorption of phosphate(s) from blood - are coated with low mol. wt., permeable, hydrophilic polymer, pref. colloidion, and used to treat renal insufficient Download PDF

Info

Publication number
FR2522282A1
FR2522282A1 FR8203329A FR8203329A FR2522282A1 FR 2522282 A1 FR2522282 A1 FR 2522282A1 FR 8203329 A FR8203329 A FR 8203329A FR 8203329 A FR8203329 A FR 8203329A FR 2522282 A1 FR2522282 A1 FR 2522282A1
Authority
FR
France
Prior art keywords
blood
beads
zirconium oxide
material according
adsorbent material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8203329A
Other languages
French (fr)
Inventor
G Denis Messier
Tms Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CAN MED Inc
Original Assignee
CAN MED Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CAN MED Inc filed Critical CAN MED Inc
Priority to FR8203329A priority Critical patent/FR2522282A1/en
Publication of FR2522282A1 publication Critical patent/FR2522282A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0211—Compounds of Ti, Zr, Hf
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/20—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/2803—Sorbents comprising a binder, e.g. for forming aggregated, agglomerated or granulated products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3042—Use of binding agents; addition of materials ameliorating the mechanical properties of the produced sorbent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/305—Addition of material, later completely removed, e.g. as result of heat treatment, leaching or washing, e.g. for forming pores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3078—Thermal treatment, e.g. calcining or pyrolizing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/42—Materials comprising a mixture of inorganic materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/62—In a cartridge

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Adsorption material, esp. for adsorption of phosphates contained in the blood, comprise porous beads containing zirconium oxide and coated witha permeable, hydrophilic polymer of low mol. wt. cpds. Before coating, the beads pref. comprise 20-100 wt.% zirconium specific surface area of 500-1300 sqm/g. The pref. coating is collodion, of about 0.05 micron thickness. Adsorbent cartridges containing the above material are also claimed. Treatment of patients suffering from chronic renal insufficiency, so as to reduce blood phosphate levels during extracorporal blood treatment. The treatment may be effected on the whole blood, the plasma or on a haemofiltrate prior to reinjection.

Description

La présente invention concerne un matériau adsorbant destiné notamment à l'adsorption des phosphates contenus dans le sang. The present invention relates to an adsorbent material intended in particular for the adsorption of phosphates contained in the blood.

On connaît de nombreuses méthodes de traitement extra-corporel du sang qui sont utilisées pour le traitement de patients souffrant d'insuffisance rénale chronique. Ces méthodes sont notamment
- l'hémodialyse, qui consiste à faire passer les substances à éliminer à travers une membrane semiperméable;
- l'hémoperfusion, qui consiste à faire adsorber certaines substances sur un matériau adsorbant;
- l'hémofiltration;
- l'hémodiafiltration;
- la dialyse péritonéale;
- la séparation plasmatique.Numerous methods of extra-corporeal blood treatment are known which are used for the treatment of patients suffering from chronic renal failure. These methods include
- hemodialysis, which consists in passing the substances to be eliminated through a semipermeable membrane;
- hemoperfusion, which consists in adsorbing certain substances on an adsorbent material;
- hemofiltration;
- hemodiafiltration;
- peritoneal dialysis;
- plasma separation.

Dans la plupart de ces méthodes, la teneur en phosphates n'est pas suffisamment diminuée. Or, il est connu que des taux de phosphates élevés dans le sang provoquent des perturbations métaboliques. In most of these methods, the phosphate content is not reduced enough. However, it is known that high levels of phosphates in the blood cause metabolic disturbances.

De plus, les adsorbants classiques (tels que le charbon actif) ne permettent pas un abaissement suffisant des taux de phosphates. In addition, conventional adsorbents (such as activated carbon) do not allow a sufficient lowering of the phosphate levels.

La présente invention vise à fournir un matériau adsorbant permettant d'abaisser suffisamment les taux de phosphates contenus dans le sang. The present invention aims to provide an adsorbent material making it possible to sufficiently lower the levels of phosphates contained in the blood.

A cet effet, la présente invention a pour objet un matériau adsorbant constitué de perles poreuses contenant de l'oxyde de zirconium et revêtues d'une mince pellicule d'un polymère hydrophile perméable aux composés de faible masse moléculaire. To this end, the present invention relates to an adsorbent material consisting of porous beads containing zirconium oxide and coated with a thin film of a hydrophilic polymer permeable to low molecular weight compounds.

Ces perles poreuses contiennent avantageusement de 20 à 100 % en poids d'oxyde de zirconium. These porous beads advantageously contain from 20 to 100% by weight of zirconium oxide.

Ces perles ont avantageusement une taille moyenne de particules de 100 à 900 microns, de préférence de 300 à 600 microns , et une surface spécifique avant revêtement de 500 à 1300 m2/g. These beads advantageously have an average particle size of 100 to 900 microns, preferably 300 to 600 microns, and a specific surface before coating of 500 to 1300 m2 / g.

Les perles poreuses utilisées dans la présente invention peuvent être fabriquées par mélange d'oxyde de zirconium en poudre (ayant avantageusement une taille de particules inférieure à 20 ) avec un liant organique décomposable thermiquement, formation de billes ou particules à partir du mélange obtenu et chauffage à une température suffisante pour décomposer le liant et fournir des perles composées d'oxyde de zirconium et de carbone ou même d'oxyde de zirconium seul (par décomposition en atmosphère oxydante). The porous beads used in the present invention can be manufactured by mixing powdered zirconium oxide (advantageously having a particle size of less than 20) with an organic binder which can be decomposed thermally, formation of beads or particles from the mixture obtained and heating at a temperature sufficient to decompose the binder and provide beads composed of zirconium oxide and carbon or even of zirconium oxide alone (by decomposition in an oxidizing atmosphere).

Le liant organique peut contenir, outre du carbone et de l'hydrogène, de l'oxygène et de 1 azote, mais doit être exempt de contaminants tels que le soufre et le chlore. The organic binder may contain, in addition to carbon and hydrogen, oxygen and nitrogen, but must be free of contaminants such as sulfur and chlorine.

Un procédé de préparation de perles poreuses qui peut Stre utilisé à out effet est décrit dans le brevet US 4 256 676. A process for preparing porous beads which can be used for any purpose is described in US Pat. No. 4,256,676.

Selon ce procédé, on obtient des perles poreuses contenant un oxyde métallique en mélangeant l'oxyde métallique en poudre avec un liant organique décomposable thermiquement. Ce liant peut être notamment un monomère thermopolymérisable, tel que le styrène, le divinyl benzène, l'alcool furfurylique ou une résine phénol formaldéhyde liquide. According to this process, porous beads containing a metal oxide are obtained by mixing the powdered metal oxide with an organic binder which can be decomposed thermally. This binder can in particular be a thermopolymerizable monomer, such as styrene, divinyl benzene, furfuryl alcohol or a liquid phenol formaldehyde resin.

Des agents de réglage de la porosité peuvent être également incorporés au mélange, par exemple de la cellulose, de la farine de bois, de l'amidon ou du sucre. Porosity adjusting agents can also be incorporated into the mixture, for example cellulose, wood flour, starch or sugar.

Le mélange est ensuite mis sous forme de billes par passage à travers un tamis ayant une taille de maille appropriée. Puis, les billes sont chauffées à une température suffisante pour polymériser ou réticuler le liant. The mixture is then formed into beads by passing through a sieve having an appropriate mesh size. Then, the beads are heated to a temperature sufficient to polymerize or crosslink the binder.

Les billes sont ensuite chauffées à une température pouvant aller jusqu'à 3500C pour décomposer le liant et obtenir un matériau composite constitué essentiellement de carbone et d'oxyde métallique. The beads are then heated to a temperature of up to 3500C to decompose the binder and obtain a composite material consisting essentially of carbon and metal oxide.

Un chauffage à 9000C en atmosphère oxydante permet d'obtenir des perles constituées uniquement d'oxyde métallique.  Heating to 9000C in an oxidizing atmosphere makes it possible to obtain pearls consisting solely of metal oxide.

Les perles à base d'oxyde de zirconium qui peuvent être ainsi obtenues sont ensuite revêtues d'une mince pellicule d'un polymère hydrophile perméable aux composés de faible masse moléculaire (c'est-à-dire notamment perméable aux ions phosphates). The beads based on zirconium oxide which can be obtained in this way are then coated with a thin film of a hydrophilic polymer permeable to low molecular weight compounds (that is to say in particular permeable to phosphate ions).

Ce revêtement peut être, en particulier, une mince pellicule obtenue par application d'un collodion, notamment par la technique de microencapsuîation par évaporation. Le collodion utilisé peut contenir par exemple 5 % de pyroxyline, 80 % d'éther et 15 % d'éthanol. Il est avantageusement appliqué en une quantité permettant d'obtenir une épaisseur de 0,05 micron environ de la pellicule de microencapsulation. This coating can be, in particular, a thin film obtained by application of a collodion, in particular by the technique of microencapsuîation by evaporation. The collodion used can for example contain 5% pyroxyline, 80% ether and 15% ethanol. It is advantageously applied in an amount making it possible to obtain a thickness of approximately 0.05 micron of the microencapsulation film.

Ce revêtement permet de rendre les perles biocompatibles avec le sang et donc utilisables pour adsorber les phosphates contenus dans le sang lors d'un traitement extracorporel. This coating makes the beads biocompatible with blood and therefore usable for adsorbing the phosphates contained in the blood during an extracorporeal treatment.

Les perles peuvent être placées dans des cartouches qui sont insérées dans le circuit de circulation extracorporelle. Elles peuvent être également mélangées à d'autres matériaux adsorbants. The beads can be placed in cartridges which are inserted into the extracorporeal circulation circuit. They can also be mixed with other adsorbent materials.

Le traitement peut être effectué sur le sang entier ou sur le plasma ou hémofiltrat avant leur réinjection. The treatment can be carried out on whole blood or on plasma or hemofiltrate before their reinjection.

Les exemples suivants illustrent la présente invention. The following examples illustrate the present invention.

EXEMPLE 1
On mélange intimement les constituants suivants:
a) 1 kg de styrène liquide,
b) 4 kg de poudre d'oxyde de zirconium ayant une taille de particules inférieure à 20 tt,
c) 1 kg de poudre de cellulose.EXAMPLE 1
The following constituents are intimately mixed:
a) 1 kg of liquid styrene,
b) 4 kg of zirconium oxide powder having a particle size of less than 20 tt,
c) 1 kg of cellulose powder.

On obtient une påte que l'on roule sur un tamis ayant des ouvertures de 300 microns. A paste is obtained which is rolled on a sieve having openings of 300 microns.

Les billes ainsi formées sont séchées à une température de 800C et ensuite chauffées à 350 C.  The beads thus formed are dried at a temperature of 800C and then heated to 350 C.

On obtient des perles poreuses constituées d'oxyde de zirconium et de carbone.  Porous beads are obtained which consist of zirconium oxide and carbon.

Les perles ainsi obtenues sont microencapsulées par mélange et agitation avec 5 % par rapport au poids des perles d'un collodion comprenant en poids 80 % d'éther, 15 % d'éthanol et 5 % de pyroxyline (ou fulmicoton)
En s'évaporant, l'éther et l'éthanol laissent une mince pellicule de 0,05 A de pyroxyline à la surface des perles.The pearls thus obtained are microencapsulated by mixing and stirring with 5% relative to the weight of the pearls of a collodion comprising by weight 80% ether, 15% ethanol and 5% pyroxyline (or fulmicoton)
As it evaporates, the ether and ethanol leave a thin film of 0.05 A of pyroxyline on the surface of the beads.

EXEMPLE 2
On procède comme à l'exemple 1, mais on poursuit le chauffage des perles jusqu'd 9000C en présence d'air.EXAMPLE 2
The procedure is as in Example 1, but the heating of the beads is continued up to 9000C in the presence of air.

On obtient des perles constituées uniquement d'oxyde de zirconium. Pearls are obtained which consist solely of zirconium oxide.

Les perles ainsi obtenues sont ensuite microencapsulées comme à l'exemple 1.  The beads thus obtained are then microencapsulated as in Example 1.

EXEMPLE 3
En procédant comme à l'exemple 1, on a préparé des perles contenant 55 % d'oxyde de zirconium.EXAMPLE 3
By proceeding as in Example 1, beads were prepared containing 55% of zirconium oxide.

Ces perles ont permis de fixer en une dizaine de minutes une quantité importante de phosphates.  These pearls made it possible to fix in ten minutes a large amount of phosphates.

Claims (9)

REVENDICATIONS 1. Matériau adsorbant destiné notamment à l'adsorption des phosphates contenus dans le sang, caractérisé en ce qu'il est constitué de perles poreuses contenant de l'oxyde de zirconium et revêtues d'un polymère hydrophile perméable aux composés de faible masse moléculaire. 1. adsorbent material intended in particular for the adsorption of phosphates contained in the blood, characterized in that it consists of porous beads containing zirconium oxide and coated with a hydrophilic polymer permeable to low molecular weight compounds. 2. Matériau adsorbant selon la revendication 1, caractérisé en ce qu'il comprend avant revêtement de 20 à 100 % en poids d'oxyde de zirconium. 2. adsorbent material according to claim 1, characterized in that it comprises, before coating, from 20 to 100% by weight of zirconium oxide. 3. Matériau adsorbant selon la revendication 1 ou la revendication 2, caractérisé en ce que les perles ont une taille moyenne de particules de 100 à 900 microns. 3. adsorbent material according to claim 1 or claim 2, characterized in that the beads have an average particle size of 100 to 900 microns. 4. Matériau adsorbant selon l'une quelconque des revendications précédentes, caractérisé en ce que les perles ont avant revêtement une surface spécifique de 500 à 1300 m2/g. 4. adsorbent material according to any one of the preceding claims, characterized in that the beads have before coating a specific surface of 500 to 1300 m2 / g. 5. Matériau adsorbant selon l'une quelconque des revendications précédentes, caractérisé en ce que les perles poreuses sont recouvertes d'une pellicule obtenue par application de. collodion.  5. adsorbent material according to any one of the preceding claims, characterized in that the porous beads are covered with a film obtained by application of. collodion. 6. Matériau adsorbant selon la revendication 5, caractérisé en ce que l'épaisseur de la pellicule est d'environ 0,05 micron. 6. adsorbent material according to claim 5, characterized in that the thickness of the film is approximately 0.05 microns. 7. Procédé de préparation d'un matériau adsorbant selon l'une quelconque des revendications 1 à 6, caractérisé en ce qu'on mélange de l'oxyde de zirconium en poudre avec un liant organique décomposable thermiquement, on met le mélange obtenu sous forme de billes, on chauffe ces billes à une température suffisante pour décomposer le liant et on revêt les perles ainsi obtenues d'une mince pellicule d'un polymère hydrophile perméable aux composés de faible masse moléculaire. 7. A method of preparing an adsorbent material according to any one of claims 1 to 6, characterized in that the powdered zirconium oxide is mixed with an organic binder which can be decomposed thermally, the mixture obtained is put in the form beads, these beads are heated to a temperature sufficient to decompose the binder and the beads thus obtained are coated with a thin film of a hydrophilic polymer permeable to low molecular weight compounds. 8. Procédé d'adsorption des phosphates contenus dans le sang, caractérisé en ce que l'on fait passer du sang ou un liquide obtenu à partir du sang sur un matériau selon l'une quelconque des revendications 1 à 6. 8. A process for the adsorption of phosphates contained in blood, characterized in that blood or a liquid obtained from blood is passed over a material according to any one of claims 1 to 6. 9. Cartouche adsorbante destinée à l'adsorption des phosphates contenus dans le sang, caractérisée en ce qu'elle contient un matériau selon l'une quelconque des revendications 1 à 6.  9. adsorbent cartridge intended for the adsorption of phosphates contained in the blood, characterized in that it contains a material according to any one of claims 1 to 6.
FR8203329A 1982-03-01 1982-03-01 Zirconium oxide beads for absorption of phosphate(s) from blood - are coated with low mol. wt., permeable, hydrophilic polymer, pref. colloidion, and used to treat renal insufficient Pending FR2522282A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8203329A FR2522282A1 (en) 1982-03-01 1982-03-01 Zirconium oxide beads for absorption of phosphate(s) from blood - are coated with low mol. wt., permeable, hydrophilic polymer, pref. colloidion, and used to treat renal insufficient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8203329A FR2522282A1 (en) 1982-03-01 1982-03-01 Zirconium oxide beads for absorption of phosphate(s) from blood - are coated with low mol. wt., permeable, hydrophilic polymer, pref. colloidion, and used to treat renal insufficient

Publications (1)

Publication Number Publication Date
FR2522282A1 true FR2522282A1 (en) 1983-09-02

Family

ID=9271435

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8203329A Pending FR2522282A1 (en) 1982-03-01 1982-03-01 Zirconium oxide beads for absorption of phosphate(s) from blood - are coated with low mol. wt., permeable, hydrophilic polymer, pref. colloidion, and used to treat renal insufficient

Country Status (1)

Country Link
FR (1) FR2522282A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448302A2 (en) * 1990-03-22 1991-09-25 Regents Of The University Of Minnesota Carbon-clad inorganic oxide particles and the same with a polymer coating thereon
US5182016A (en) * 1990-03-22 1993-01-26 Regents Of The University Of Minnesota Polymer-coated carbon-clad inorganic oxide particles
US5271833A (en) * 1990-03-22 1993-12-21 Regents Of The University Of Minnesota Polymer-coated carbon-clad inorganic oxide particles
US5346619A (en) * 1990-03-22 1994-09-13 Regents Of The University Of Minnesota Carbon-clad zirconium oxide particles
WO2008012064A1 (en) * 2006-07-25 2008-01-31 Chromatide Ltd Solid support

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2239282A1 (en) * 1973-07-31 1975-02-28 Nat Patent Dev Corp
US4048064A (en) * 1976-04-23 1977-09-13 Clark Iii William T Biocompatible hemoperfusion system
US4256676A (en) * 1978-11-22 1981-03-17 Kovach Julius L Process for preparing porous metal oxide beads
GB2056429A (en) * 1979-08-16 1981-03-18 Takeda Chemical Industries Ltd Ion adsorbent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2239282A1 (en) * 1973-07-31 1975-02-28 Nat Patent Dev Corp
US4048064A (en) * 1976-04-23 1977-09-13 Clark Iii William T Biocompatible hemoperfusion system
US4256676A (en) * 1978-11-22 1981-03-17 Kovach Julius L Process for preparing porous metal oxide beads
GB2056429A (en) * 1979-08-16 1981-03-18 Takeda Chemical Industries Ltd Ion adsorbent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/79 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448302A2 (en) * 1990-03-22 1991-09-25 Regents Of The University Of Minnesota Carbon-clad inorganic oxide particles and the same with a polymer coating thereon
EP0448302A3 (en) * 1990-03-22 1991-11-13 Minnesota Mining And Manufacturing Company Carbon-clad inorganic oxide particles and the same with a polymer coating thereon
US5182016A (en) * 1990-03-22 1993-01-26 Regents Of The University Of Minnesota Polymer-coated carbon-clad inorganic oxide particles
US5271833A (en) * 1990-03-22 1993-12-21 Regents Of The University Of Minnesota Polymer-coated carbon-clad inorganic oxide particles
US5346619A (en) * 1990-03-22 1994-09-13 Regents Of The University Of Minnesota Carbon-clad zirconium oxide particles
EP0635301A2 (en) * 1990-03-22 1995-01-25 Regents Of The University Of Minnesota Carbon-clad inorganic oxide particles with a polymer coating thereon
EP0635301A3 (en) * 1990-03-22 1995-03-22 Univ Minnesota Carbon-clad inorganic oxide particles with a polymer coating thereon.
WO2008012064A1 (en) * 2006-07-25 2008-01-31 Chromatide Ltd Solid support

Similar Documents

Publication Publication Date Title
US5019260A (en) Filtration media with low protein adsorbability
FR2493351A1 (en)
CA1057595A (en) Coated bead-shaped activated carbon for purifying blood
FR2466518A1 (en) PROCESS FOR THE PRODUCTION OF FIBROUS ACTIVE CHARCOAL USING ACRYLONITRILE FIBER
CN102671629A (en) Absorbent with high blood compatibility
CN1263534C (en) Hollow fiber membrane for purifying blood and method for preparation thereof
JPS639869B2 (en)
FR2522282A1 (en) Zirconium oxide beads for absorption of phosphate(s) from blood - are coated with low mol. wt., permeable, hydrophilic polymer, pref. colloidion, and used to treat renal insufficient
FR2608452A1 (en) PROCESS FOR HYDROPHOBIZING MATERIALS FOR AIR FILTERS IMPERMEABLE TO MICROBACTERIA
US4169051A (en) Blood purification with coated activated carbon spheres
US4350173A (en) Filter material
CA1303013C (en) Silver based catalyst for producing ethylene oxyde
US5849195A (en) Composite membrane, process of manufacturing it and process of using it
WO2013187396A1 (en) Separation membrane for blood treatment and blood treatment device having same membrane incorporated therein
EP0088006B1 (en) Process for the preparation of porous products based on cobalt fluoride or lead fluoride
RU2208441C2 (en) Perfluoropolymer-containing carbon hemosorbent and method for its preparing
US7591948B2 (en) Process for production of a regioselective membrane
EP3812349A1 (en) Activated carbon
Lamb et al. CONTRIBUTIONS FROM THE CHEMICAL WARFARE SERVICE, US A: Gas MAsk Absorbents.
JP2008246439A (en) Adsorbent for organic urea based compound, adsorption device for organic urea based compound, and treatment method for organic urea based compound
RU2662577C1 (en) Method for obtaining composition based on alumina
RU2118898C1 (en) Method of producing perfluoropolymer-containing carbonic hemosorbent
GB2233248A (en) Enantiomer enrichment by membrane processes
KR102563115B1 (en) Antibacterial and antiviral CuBTC-PMF and its manufacturing method
JPS6121702A (en) Porous film and manufacture thereof