FR2513119A1 - Protection and treatment of dental wounds - using compsns. contg. calcium peroxide - Google Patents

Protection and treatment of dental wounds - using compsns. contg. calcium peroxide Download PDF

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Publication number
FR2513119A1
FR2513119A1 FR8117974A FR8117974A FR2513119A1 FR 2513119 A1 FR2513119 A1 FR 2513119A1 FR 8117974 A FR8117974 A FR 8117974A FR 8117974 A FR8117974 A FR 8117974A FR 2513119 A1 FR2513119 A1 FR 2513119A1
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Prior art keywords
calcium
peroxide
calcium peroxide
wounds
dental
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FR8117974A
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French (fr)
Inventor
Pierre Denis Bernard
Bernard Tessier
Herve G Guitton
Elise Murgier
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DENTALPHY STE CIVILE
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DENTALPHY STE CIVILE
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Priority to FR8117974A priority Critical patent/FR2513119A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Superficial wounds, esp. dental wounds, are covered and protected by a prod. contg. calcium peroxide. The calcium peroxide may be mixed with calcium hydroxide, in a proportion up to total replacement of hydroxide. The peroxide supplies nascent oxygen which compensates for the lack of physiological oxygen and aids survival of dental pulp affected by ischemic gangrene. The calcium peroxide may also be mixed with calcium oxide, and has the advantage of giving a foamed solid, facilitating penetration of probes etc.. The calcium peroxide may be further mixed with sodium peroxide, which modifies the rate of reaction and renders it safer. The prod. is better tolerated and more effective than conventional materials used for dental wounds, such as calcium-or sodium peroxide.

Description

La présente invention a pour objet un produit de recouvrement et de protection de la surface de plaies superficielles, et notamment de plaies dentaires. The present invention relates to a product for covering and protecting the surface of superficial wounds, and in particular dental wounds.

On connait l'action physiologique de lBhydroxyde de calcium (chaux éteinte) appliqué en médecine, et surtout en art dentaire pour recouvrir et protéger la surface de plaies superficielles et notamment de la pulpe dentaire et en permettre la cicatrisation. We know the physiological action of calcium hydroxide (slaked lime) applied in medicine, and especially in dentistry to cover and protect the surface of superficial wounds and in particular dental pulp and to allow healing.

L'hydroxyde de calcium a normalement une action caustique par alcalinité. Or, cette action ne se manifeste pas au contact des tissus vivants du fait que l'alcalinité est neutralisée par le bioxyde de carbone (Co2 ou gaz carbonique), constamment produit par l'activité des tissus (métabolisme basal) qui absorbe lBoxygène apporté par le sang artériel et qui produit du C02 évacué par le sang veineux. Calcium hydroxide normally has a caustic action by alkalinity. However, this action does not manifest itself in contact with living tissues because alkalinity is neutralized by carbon dioxide (Co2 or carbon dioxide), constantly produced by the activity of tissues (basal metabolism) which absorbs the oxygen provided by arterial blood and which produces C02 evacuated by venous blood.

Au contact de ce CO2, l'hydroxyde de calcium se transforme en carbonate de calcium neutre et en eau selon la réaction

Figure img00010001

les ions OH, facteurs dalcalinité caustique ont localement disparus.On contact with this CO2, the calcium hydroxide transforms into neutral calcium carbonate and water according to the reaction
Figure img00010001

OH ions, caustic alkalinity factors have locally disappeared.

Du C02 étant ainsi absorbe' il résulte une carence relative du C02 dans 1 9équilibre du rapport (O2 F C02), qui est une constante physiologique rigoureuse. L'équilibre ainsi rompu est aussitSt rétabli par une augmentation du métabolisme basal qui consomste de l'oxygène apporté par le sang. Le COa disparu est reformé et peut ainsi poursuivre son action neutralisante sur l'hydroxyde. C02 being so absorbed, there results a relative deficiency of C02 in the balance of the ratio (O2 F C02), which is a rigorous physiological constant. The balance thus broken is immediately restored by an increase in the basal metabolism which consumes oxygen supplied by the blood. The disappeared COa is reformed and can thus continue its neutralizing action on the hydroxide.

Cependant, dans certains cas pathologiques, se traduisant par un ralentissement ou même un arret de la circulation sanguine, il y a ischémie, c'est-à-dire asphyxie locale ou anoxie par carence dIoxygene. Dans ce cas, l'hydroxyde de calcium conserve sa causticite et provoque une irritation douloureuse. However, in certain pathological cases, resulting in a slowing down or even a stopping of the blood circulation, there is ischemia, that is to say local asphyxia or anoxia by deficiency of oxygen. In this case, the calcium hydroxide retains its causticity and causes painful irritation.

Un autre produit connu en art dentaire est le peroxyde de sodium ou oxylithe, utilisé dans les cas de mortification et gangrène de la pulpe dentaire pour détruire les débris cadavériques par la soude caustique. De par sa réaction chimique avec l'eau dentaire, le peroxyde de sodium donne de la soude et de ltoxygène suivant la réaction

Figure img00020001
Another product known in dentistry is sodium peroxide or oxylith, used in cases of mortification and gangrene of the dental pulp to destroy cadaveric debris by caustic soda. Due to its chemical reaction with dental water, sodium peroxide gives sodium hydroxide and oxygen depending on the reaction
Figure img00020001

Mais cette réaction, très exothermique, est très vive et parfois explosive, avec projection de gouttelettes de soude caustique très chaudes. But this reaction, very exothermic, is very strong and sometimes explosive, with projection of very hot caustic soda droplets.

La présente invention vise à remédier notamment aux inconvénients des produits définis ci-dessus. The present invention aims to remedy in particular the drawbacks of the products defined above.

A cet effet, le produit quelle concerne contient du peroxyde de calcium. To this end, the product which it concerns contains calcium peroxide.

Selon un premier mode de mise en oeuvre, le peroxyde de calcium est incorporé à de l'hydroxyde de calcium. Cette incorporation à l'hydroxyde de calcium peut se faire dans des proportions qui peuvent aller jusqu'au remplacement total de l'hydroxyde par le peroxyde de calcium. According to a first embodiment, the calcium peroxide is incorporated into calcium hydroxide. This incorporation into the calcium hydroxide can be carried out in proportions which can go as far as the total replacement of the hydroxide with calcium peroxide.

Cette association est intéressante car le peroxyde de calcium produit un dégagement d'oxygène "naissant", compensant une éventuelle carence en oxygène physiologique. This association is interesting because calcium peroxide produces a release of "nascent" oxygen, compensating for a possible deficiency in physiological oxygen.

I1 en résulte une possibilité de survie de la pulpe vouée sans cela à la gangrène ischémique. This results in a possibility of survival of the pulp which is otherwise doomed to ischemic gangrene.

En effet, au contact de lfeau, le peroxyde de calcium donne de l'hydroxyde de calcium et de l'oxygène suivant la réaction

Figure img00020002
Indeed, in contact with water, calcium peroxide gives calcium hydroxide and oxygen depending on the reaction
Figure img00020002

Cette réaction est spontanément limitée pour une température donnée, en ltoccurrence 370C, et le dégagement d'oxygène starrAte dès que sa pression partielle dépasse celle de ltoxygène normalement présent dans les tissus.  This reaction is spontaneously limited for a given temperature, in this case 370C, and the release of oxygen stops as soon as its partial pressure exceeds that of the oxygen normally present in the tissues.

Dans ces conditions, le mEtabolisme basal reprend son activité, la causticité de l'hydroxyde est neutralisée et il ntapparatt aucune réaction morbide, en particulier aucune douleur. Under these conditions, the basal metabolism resumes its activity, the causticity of the hydroxide is neutralized and there does not appear any morbid reaction, in particular no pain.

Selon une seconde possibilité, le peroxyde de calcium est incorporé à de l'oxyde de calcium CaO. L'oxyde de calcium (chaux vive) est utilisé en dentisterie dans les cas de canaux dentaires inaccessibles aux sondes et autres instruments (canaux étroits, coudés ou ramifiés...). On exploite dans ces cas le phénomène d'expansion volumétrique (foisonnement), qui accompagne l'hydratation de l'oxyde, avec formation dthydroxyde de calcium selon la réaction

Figure img00030001
According to a second possibility, the calcium peroxide is incorporated into calcium oxide CaO. Calcium oxide (quicklime) is used in dentistry in the case of dental canals inaccessible to probes and other instruments (narrow, bent or branched canals ...). In these cases, the phenomenon of volumetric expansion (expansion) is exploited, which accompanies the hydration of the oxide, with the formation of calcium hydroxide depending on the reaction.
Figure img00030001

Cette expansion permet la pénétration du produit dans les zones inaccessibles aux instruments. Mais cette expansion est limitée par les parois rigides (ivoire ou dentine) du canal. Cette limitation se traduit par une impansion ou condensation du type crayeux ou marmoréen, cest-à-dire tras dure.Cette dureté est un obstacle pour le praticien qui a besoin d'avoir accès dans le canal pour, par exemple, y placer un tenon prothétique. This expansion allows the penetration of the product into areas inaccessible to the instruments. However, this expansion is limited by the rigid walls (ivory or dentin) of the canal. This limitation results in an expansion or condensation of chalky or marmoreal type, that is to say very hard. This hardness is an obstacle for the practitioner who needs to have access to the canal to, for example, place a tenon there. prosthetic.

Lwincorporation de peroxyde de calcium produit un dégagement d'oxygène réparti dans la masse hydro-calcique, et lui donne une structure hétérogène, micro-cavitaire. The incorporation of calcium peroxide produces a release of oxygen distributed in the hydro-calcic mass, and gives it a heterogeneous, micro-cavitary structure.

On a une écume calcique, comme écume de mer silico magns denne, qui a une consistance spumeuse, ce qui facilite la pénétration des sondes et autres instruments dans le canal.We have a calcium foam, like sea foam silico magns denne, which has a frothy consistency, which facilitates the penetration of probes and other instruments in the canal.

Selon une autre possibilité, le peroxyde de calcium est incorporé à son homologue sodique le peroxyde de sodium. Alternatively, calcium peroxide is incorporated into its sodium counterpart sodium peroxide.

Par 1 'incorporation de peroxyde de calcium dont la réaction dthydratation est très lente, contrairement à celle du peroxyde e sodium, la masse de peroxyde de sodium est dispersée dans celle de peroxyde de calcium, de telle sorte que la vivacité de la réaction d'hydratation est considérablement atténuée et n'est plus explosive.  By the incorporation of calcium peroxide whose hydration reaction is very slow, unlike that of sodium peroxide, the mass of sodium peroxide is dispersed in that of calcium peroxide, so that the liveliness of the reaction hydration is considerably attenuated and is no longer explosive.

Claims (5)

- REVENDICATIONS  - CLAIMS 1. - Produit de recouvrement et de protection de la surface de plaies superficielles, caractérisé en ce qu'il contient du peroxyde de calcium. 1. - Product for covering and protecting the surface of superficial wounds, characterized in that it contains calcium peroxide. 2. - Produit selon la revendication t, caractérisé en ce que le peroxyde de calcium est incorporé à de l'hydre xyde de calcium. 2. - Product according to claim t, characterized in that the calcium peroxide is incorporated into calcium hydroxide. 3. - Produit selon la revendication 2, caractérisé en ce que le peroxyde de calcium est incorporé à de l'hydro- xyde de calcium dans des proportions pouvant aller jusqu au remplacement total de ithydroxyde par le peroxyde de calcium. 3. - Product according to claim 2, characterized in that the calcium peroxide is incorporated into calcium hydroxide in proportions which may go as far as the total replacement of ithydroxide by calcium peroxide. 4. - Produit selon la revendication 1, caractérisé en ce que le peroxyde de calcium est incorporé à de ltoxyde de calcium. 4. - Product according to claim 1, characterized in that the calcium peroxide is incorporated into calcium oxide. 5. - Produit selon la revendication 1, caractérise en ce que le peroxyde de calcium est incorporé à du peroxyde de sodium.  5. - Product according to claim 1, characterized in that the calcium peroxide is incorporated into sodium peroxide.
FR8117974A 1981-09-18 1981-09-18 Protection and treatment of dental wounds - using compsns. contg. calcium peroxide Pending FR2513119A1 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897258A (en) * 1987-01-12 1990-01-30 Peroxydent Group Periodontal composition and method
US4980154A (en) * 1988-06-23 1990-12-25 Norman Gordon Tooth and gum dentifrice composition and method of making same
US5000942A (en) * 1989-11-20 1991-03-19 Libin Barry M Oral hygiene composition
US11318106B2 (en) * 2007-04-09 2022-05-03 Wake Forest University Health Sciences Oxygen-generating compositions for enhancing cell and tissue survival in vivo

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1972 *
EXBK/76 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897258A (en) * 1987-01-12 1990-01-30 Peroxydent Group Periodontal composition and method
US4980154A (en) * 1988-06-23 1990-12-25 Norman Gordon Tooth and gum dentifrice composition and method of making same
US5000942A (en) * 1989-11-20 1991-03-19 Libin Barry M Oral hygiene composition
US11318106B2 (en) * 2007-04-09 2022-05-03 Wake Forest University Health Sciences Oxygen-generating compositions for enhancing cell and tissue survival in vivo

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