FR2510563A1 - ALLANTOIN AND COLLAGEN AMINO ACID COMPOSITIONS - Google Patents

Abstract

ALLANTOIN AND COLLAGEN AMINO ACID COMPLEXES. THE INVENTION DESCRIBES AMINO ACID COMPLEXES OF ALLANTOIN AND COLLAGEN. IT ALSO DESCRIBES MEDICINAL AND COSMETIC COMPOSITIONS CONTAINING AMINO ACID COMPLEXES OF ALLANTOIN AND COLLAGEN.

Description

Alloy amino acids of allantoin and collagen

  Allantoin has calming properties, keratolytic

  ticks, humidification and anti-irritants In the past,

  allantoin has been complexed by means of individual amino acids

  allantoin and amino acid complexes

  Sulfur such as methionine are described in U.S. Patent No. 3,107,252. Alloy pantothenic acid complexes are described in US Pat.

  United States No. 3,275,643 Biotin complexes of

  The complexes of allantoin glycine are described in U.S. Patent No. 3,927,021. Alloy complexes with basic amino acids are described in US Pat. U.S. Patent No. 4,038,287 The complexes described in the above patents are useful in medicinal and pharmaceutical compositions.

  There is a need for amino acid complexes of

  and collagen to combine the beneficial properties of allantoin with amino acids derived from

  animal proteins such as collagen.

  The present invention relates to allantoin and collagen amino acid complexes. The invention also provides aluminum salts of allantoin and collagen amino acid complexes, as well as compositions

  medicinal products and cosmetics containing the complexes of the invention.

tion.

  Alleroine stimulates the proliferation of cells. It is also slightly keratolytic and constitutes a

  dispersant of proteins allantol has properties

  calming and pain relief, as well as

humidification properties.

  Collagen is a protein consisting of amino acids linked in a chain by peptide bonds The amino acids of collagen which are useful in the context of the present invention are derived from animal proteins and they have the following typical composition of the amino acid :

AMINO ACID% PRESENT

  Alanine 8 11 Arginine 7.8 9 Aspartic acid 5.7 9 Cystine / cysteine 0.1 0, 9 Glycine 20 30.5 Glutamic acid 10 11.7 Histidine 0.7 1 Hydroxylsin 0.7 Hydroxyproline 12.1 14.5 Iso-leucine 1.3 1.8 Leucine 2.8 3.5 Lysine 3.9 5.2 Methionine 0.7 0.9 Phenylalanine 1.1 2.6 Proline 13.8 18 Serine 2, 9 4 , 1 Threonine 1,8 2,6 Tyrosine 0,2 1 Valine 2,1 3,4 The amino acids of collagen which are useful in the context of the present invention are highly refined hydrolysates In other words, derived collagen from a variety of different sources is hydrolysed using techniques

  with an acid, an alkali or by hydrolysis of enzymes.

  to produce amino acids of collagen having the composition indicated above and whose molecular weight is between about 100,000 and 200,000 amino acids hydrolysed collagen which are useful in the context

  of the present invention are liquids having a com

  taken between about 5 and 6.5 and containing about 70% by weight of free amino acids and about 38 to 42% by weight of protein.

  To form the desired complexes, it is not necessary to

  Providing special conditions for the reaction A method may be used in which allantoin or aluminum salts of allantoin are combined with liquid collagen amino acids and mixed uniformly to form a moist mass. wet mass is then dried between 82% and 99 C until the product is dry and has a relatively constant weight. Drying is usually done over a period of four to four months.

  six hours, and it can be done by any means

  including dry spray Dry complexes are powders with a melting point between

about 104 and 106 C.

  According to the present invention, allantoin or aluminum salts of allantoin can be combined with amino acids of collagen in a ratio by weight of between about 50 and 80 parts of allantoin or its aluminum salts and about 20 to 50 parts of amino acids of

collagen.

  It has been found that the amino acid complexes of

  Tooth and collagen are remarkably beneficial when used in pharmaceutical or cosmetic compositions for topical applications.

  complexes have moisture absorption properties.

  which are more important than those expected of

  the simple addition of allantoin to amino acids of collagen

  gene This effect, which exceeds that of an addition effect, exists for a range of relative humidity and can be demonstrated by comparing the moisture absorption isotherms of allantoin and collagen amino acids with isothermal moisture of the amino acids of allantoin and

  collagen according to the present invention.

  It has been found that the topical application of pharmaceutical and cosmetic compositions containing about 0.5 to about 5% by weight of allantoin and collagen amino acid complexes is useful in a variety of applications. when topical compositions containing the complexes of the invention are applied, part of the allantoin and collagen amino acid complex penetrates the skin and brings moisture to the stratum.

  At the same time, the amino acid part of

  lantoine and collagen that does not get into the skin but

  remains on the surface of the skin exerts hygroscopic properties

  Spades and provides moisture on the surface of the skin The complex also has an action of elimination or rejection of dead skin cells, which facilitates the healing of abrasions or minor lacerations of the skin and provides a soft feeling, slightly astreingeante but nevertheless comfortably moist skin This double effect on the skin and below its surface is clearly beneficial in

  a wide variety of pharmaceutical and cosmetic compositions

  and emphasizes the unexpected nature of the invention.

  The following examples demonstrate the preparation of

  complexes of the invention, as well as the compositions

  These examples are illustrative only and are not intended to limit the scope of

the invention.

EXAMPLE -1

  80 g of allantoin are mixed thoroughly with 20 g of collagen amino acids to form a uniform moist mass. The resulting mixture is then dried at 82 ° C. for several hours, and forms a white powder. The amino acid complex of allantol and collagen is thus formed and is soluble in a proportion of 3 to 4% by weight in

  water and 1 to 2% by volume in 95% alcohol.

EXAMPLE 2

  70 g of allantoin are thoroughly mixed with 30 g of collagen amino acids to form a uniform moist mass. The resulting mixture is then dried at 82 ° C. for

  several hours, and it forms a white powder The complex.

  of allantoin and collagen amino acids is thus formed and is soluble in a proportion of 2 to 3% by weight in

  water and 1 to 2% by volume in 95% alcohol.

EXAMPLE 3

  50 g of allantoin are thoroughly mixed with 50 g of collagen amino acids to form a uniform moist mass. The resulting mixture is then dried at 82 990 ° C for several hours and forms a white powder. The amino acid complex of allantoin and collagen is thus formed and is soluble in proportion of 1% by weight in water

  and 0.5% by volume in 95% alcohol.

EXAMPLE 4

  80 g of aluminum chlorhydroxy allantolate are admixed thoroughly with

  The resulting mixture is then dried at 82 ° C. for several hours, and forms a white powder. The allantoin and collagen amino acid complex is thus combined with 20 g of collagen amino acids to form a uniform moist mass. formed and is soluble in proportions of 3 to 4% by weight in water and 1 to 2% by volume in

95% alcohol.

EXAMPLE 5

  70 g of hydrochloric acid allantoinate are mixed thoroughly with

  The resulting mixture is then dried at 82 ° C. for several hours, and forms a white powder. The allantoin and collagen amino acid complex is thus combined with 30 g of collagen amino acids to form a uniform moist mass. formed and is soluble in a proportion of 2 to 3% by weight in water and 1 to 2% by volume in

95% alcohol.

EXAMPLE 6

  50 g of aluminum chlorhydroxy allantoinate are mixed thoroughly

  The resulting mixture is then dried at 82 ° C. for several hours, and forms a white powder. The allantol and collagen amino acid complex is thus combined with 30 g of collagen amino acids to form a uniform moist mass. formed and is soluble in a proportion of 1% by weight in water and 0.5% by volume in

95% alcohol.

EXAMPLE 7

  80 g of aluminum dihydroxy allantoinate are mixed thoroughly.

  nium to 20 g of collagen amino acids to form a uniform moist mass The resulting mixture is then dried

  at 82 ° C for several hours, and forms a powder.

  The allantoin and collagen amino acid complex is thus formed and is soluble in proportions of 3 to 4% by weight in water and 1 to 2% by volume in water.

95% alcohol.

To: 10563

6

EXAMPLE 8

  70 g of aluminum dihydroxy allantoinate are admixed

  The resulting mixture is then dried at 82 ° C. for several hours, and forms a white powder. The allantol and collagen amino acid complex is thus combined with 30 g of collagen amino acids to form a uniform moist mass. formed and is soluble in a proportion of 2 to 3% by weight in water and 1 to 2% by volume in

95% alcohol.

EXAMPLE 9

  50 g of allantoin dihydroxy d: alumina are thoroughly mixed with

  The resulting mixture is then dried at 82 ° C. for several hours, and forms a white powder. The allantol and collagen amino acid complex is thus combined with 50 g of collagen amino acids to form a uniform moist mass. formed and it is soluble in proportion to

  1% by weight in water and 0.5% by volume in

95% cool.

  The following formulations have been developed for

  demonstrate the utility of the amino acid complexes of

toine and collagen.

2510563 -

LOTION FOR DRY SKIN

INGREDIENTS PERCENTAGE BY WEIGHT

  Myrj 52 1,5 Cérphyle 368 5 Span 65 0,3 Super Hartolan 0,5 Cetyl alcohol 0,75 Glyceral monostearate 5 Tegosept P 0,1 Silicone 200 1 Polymer JR 400 0,25 Propylene glycol 4,8 Deionized water 70 Germall 115 0, 1 Tegosept M 0.2 Allantoin 0.1 Carbopol 941 2.5 disp 0.1 Menthol 0.05 Aldehyde Verley 4390 HA 0.25 Ethyl vanillin 0.002 Ethylene brasilyate 0.001 Deionized water 6 Amino acid complex Example 1 4

LIPSTICK

INGREDIENTS PERCENTAGE BY WEIGHT

  Westol 350 15.0 Castor Oil 5.9 Red K 7061 D & C # 21 0.1 Red Iron Oxide A 6205 1.73 Orange # 5303 D & C # 5 1.2 Red C 14-034 D & C Lacquer # 21 A 1 0 , 98 Red # 6607 D & C # 7 0.750 Shadow 1985 R 0.450 Orange K 7081 D & C # 17 0.3

Red K 7040 D & C # 19 0.250.

  Titanium Dioxide 328 4 Westol 350 17.2 Modulan 2.9 Novol 9.7 Ceramyl 50 8.8 Ceramyl 424 7.3 Candelilla Wax 16.4 Carnauba Wax 0.9 Beeswax 0.9 Multiwax 445 0 , 9 Silicone Copolymer F 0755 0.9 Tenox II 0.1 Tegosept P 0.1 Tegosept B 0.1 Allantoin 0.1 Germanll 115 0.01 Tocopherol alpha acetate 0.1 Crotein IPX 0.1 Nopsol A 7 d 1000/200 0.1 Wheat germ oil 0.1 Goat and collagen amino acid complex of Example 1 1 FL 5995 perfume oil 0.2 Vanilla (50%) 0.1

LIP VARNISH

INGREDIENTS PERCENTAGE BY WEIGHT

  Tegosept B 0.15 Snow white petrolatum 31.9 Lanolin acetylated 36.9 Lanolin oil 15.2 Paraffin wax 5.6 Acetylated glycerides 4 Octyl Dimethyl Paba 0.5 Tenox VI 0.1 Tegosept P 0.1 Snow white petrolatum 4.75 Red D & C # 6 0.01 Floral Essence of Lemon F 5272 0.25 Amino Acid Alloy Acid and Collagen Complex of Example 1 0.25

NIGHT CREAM -

INGREDIENTS PERCENTAGE BY WEIGHT

  Hydrosylated lanolin 0.5 White beeswax 7.4 Lanolin 26.4 Lanolin alcohol 1 Yellow petrolatum 25 Sorbitan sesquioleate 2.7 Mineral oil 14.6 Tegosept P 0.1 Tegosept M 0.3 Sodium borate USP 0 , 5 Deionized water 19.6 Limon # 1 0.4 Viamine palmitate A 0.05 Imidazolydinyl urea 0.1 Goat and collagen amino acid complex

of Example 2

0.5

2510563 '

MASCARA

  INGREDIENTS POUl Beeswax Lanolin Wax White Makon Flakes Ozokerite Wax Carnauba Wax C 10-13 Isoparaffin Lecithin Tegosept P Silica Magnesium Trisilicate Hydrolyzed Animal Protein Allantoinate Dihydroxy Aluminum Allantoin Proteinate Imidazolidinyl Urea Iron Oxide black 33-134 Goat and collagen amino acid complex

of Example 3

RCENTAGE

24.4 1.5 0.5 1.0 0.1 1.30 3.5 0.5

IN WEIGHT

0.2 0.2 0.01 0.2 0.5

10563 '

BATON FOR THE EYES

PERCENTAGE INGREDIENTS

  Stearyl Heptaonate 0.9 Wax Ozokerite 6 Candelilla Wax 2.5 Carnauba Wax 3.0 Mineral Oil 85.13 Tegosept P 0.1 Tegosept B 0.1 Vitamin A & D 1000/200 0.01 Alpha Tocopheryl Acetate 0 , 1 Caryaryl octanoate 0.9 Imidazolydinyl urea 0.01 Red oxide A 6205 1% Westol 350 0.5 Carotene (0.1% in IMPM) 0.25 Allantoin amino acid complex and Collagen amine Example 1 0.5

COMPRESSED POWDER

PERCENTAGE INGREDIENTS

  Amino acid complex of Allantolne and Collagen

of Example 1

  Cosmetic Brown # 2673 Brown Iron Oxide # 2817 R Yellow Cosmetic C 1624 Cosmetic Red # 15002 Titanium Dioxide # 328 Talc Perfume Myristate Isopropyl Magnesium Carbonate Zinc Stearate BHA Tegosept M Captan

IN WEIGHT

IN WEIGHT

  0.5 0.3 0.5 0.3 0.3 86.6 2.6 0.05 0.1 0.1

Claims (3)

  1 Amino acid complexes of allantol and collagen.   2 allantoin and collagen amino acid complexes having a weight ratio of between about 3 and 80 parts of allantol-or its aluminum salts and about 20 to 50 parts of collagen amino acids. Pharmaceutical and cosmetic compositions comprising a therapeutically effective amount of acid complexes   amines of allantoin and collagen.