FR2505330B1 - Nouvelle substance carcinostatique a base d'un derive de n-(4-(3-aminopropyl) aminobutyl)-2-((s)-7-guanidino-3-hydroxyhaptanamido)-2-hydroxyethanamide et son procede de preparation - Google Patents
Nouvelle substance carcinostatique a base d'un derive de n-(4-(3-aminopropyl) aminobutyl)-2-((s)-7-guanidino-3-hydroxyhaptanamido)-2-hydroxyethanamide et son procede de preparationInfo
- Publication number
- FR2505330B1 FR2505330B1 FR8208175A FR8208175A FR2505330B1 FR 2505330 B1 FR2505330 B1 FR 2505330B1 FR 8208175 A FR8208175 A FR 8208175A FR 8208175 A FR8208175 A FR 8208175A FR 2505330 B1 FR2505330 B1 FR 2505330B1
- Authority
- FR
- France
- Prior art keywords
- hydroxyhaptanamido
- hydroxyethanamide
- aminobutyl
- guanidino
- aminopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56069340A JPS57185254A (en) | 1981-05-11 | 1981-05-11 | Novel carcinostatic substances and their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2505330A1 FR2505330A1 (fr) | 1982-11-12 |
FR2505330B1 true FR2505330B1 (fr) | 1985-06-28 |
Family
ID=13399716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8208175A Expired FR2505330B1 (fr) | 1981-05-11 | 1982-05-11 | Nouvelle substance carcinostatique a base d'un derive de n-(4-(3-aminopropyl) aminobutyl)-2-((s)-7-guanidino-3-hydroxyhaptanamido)-2-hydroxyethanamide et son procede de preparation |
Country Status (8)
Country | Link |
---|---|
US (1) | US4430346A (fr) |
JP (1) | JPS57185254A (fr) |
CA (1) | CA1182836A (fr) |
CH (1) | CH655499B (fr) |
DE (1) | DE3217547A1 (fr) |
FR (1) | FR2505330B1 (fr) |
GB (1) | GB2101123B (fr) |
IT (1) | IT1148169B (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57192347A (en) * | 1981-05-18 | 1982-11-26 | Microbial Chem Res Found | N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis |
JPS5862152A (ja) * | 1981-10-08 | 1983-04-13 | Microbial Chem Res Found | N−〔4−(3−アミノプロピル)アミノブチル〕−2−(ω−グアニジノ脂肪酸アミド)−2−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法 |
JPS60181056A (ja) * | 1984-02-29 | 1985-09-14 | Takara Shuzo Co Ltd | Ν−〔4−(3−アミノプロピル)アミノブチル〕−2,2−ジヒドロキシエタンアミドの製造法 |
JPS60185758A (ja) * | 1984-03-02 | 1985-09-21 | Microbial Chem Res Found | フエニレン基を有するスパガリン関連化合物およびその製造法 |
JPS61165322A (ja) * | 1985-01-14 | 1986-07-26 | Microbial Chem Res Found | スパガリン類の注射用凍結乾燥製剤 |
DE3770680D1 (de) * | 1986-04-04 | 1991-07-18 | Microbial Chem Res Found | Spergualinaehnliche verbindungen und ihr herstellungsverfahren. |
JPH0776204B2 (ja) * | 1988-07-01 | 1995-08-16 | 寳酒造株式会社 | スパガリン類の精製法 |
US4990536A (en) * | 1989-04-03 | 1991-02-05 | Nippon Kayaku Kabushiki Kaisha | Immunopotentiator and spergualin-related compound therefor |
US5162581A (en) * | 1989-05-29 | 1992-11-10 | Takaru Shuzo Co., Ltd. | Crystalline deoxyspergualin, process for its preparation and suppository containing the same |
EP0467280B1 (fr) * | 1990-07-20 | 1994-09-28 | Nippon Kayaku Kabushiki Kaisha | Composés apparantés de sperguline et leur utilisation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3436463A (en) | 1965-06-17 | 1969-04-01 | Gaf Corp | Pesticidal compositions comprising n-substituted gamma hydroxycarboxylic acid amides |
SU663299A3 (ru) | 1975-05-27 | 1979-05-15 | Ю.Ц.Б.С.А. (Фирма) | Способ получени бензил-2,2-диметокси ацетамидов |
DE2944456C2 (de) | 1979-11-03 | 1982-04-01 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von N-α -Alkoxyalkyl-carbonsäureamiden |
JPS5748957A (en) * | 1980-09-08 | 1982-03-20 | Microbial Chem Res Found | Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient |
-
1981
- 1981-05-11 JP JP56069340A patent/JPS57185254A/ja active Granted
-
1982
- 1982-05-06 CA CA000402381A patent/CA1182836A/fr not_active Expired
- 1982-05-07 US US06/375,950 patent/US4430346A/en not_active Expired - Lifetime
- 1982-05-10 GB GB08213793A patent/GB2101123B/en not_active Expired
- 1982-05-10 DE DE19823217547 patent/DE3217547A1/de active Granted
- 1982-05-10 CH CH288982A patent/CH655499B/de unknown
- 1982-05-11 FR FR8208175A patent/FR2505330B1/fr not_active Expired
- 1982-05-11 IT IT48385/82A patent/IT1148169B/it active
Also Published As
Publication number | Publication date |
---|---|
IT8248385A0 (it) | 1982-05-11 |
IT1148169B (it) | 1986-11-26 |
US4430346A (en) | 1984-02-07 |
DE3217547A1 (de) | 1982-12-16 |
FR2505330A1 (fr) | 1982-11-12 |
JPH0140823B2 (fr) | 1989-08-31 |
GB2101123A (en) | 1983-01-12 |
CA1182836A (fr) | 1985-02-19 |
CH655499B (fr) | 1986-04-30 |
JPS57185254A (en) | 1982-11-15 |
GB2101123B (en) | 1985-01-30 |
DE3217547C2 (fr) | 1992-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA22668A1 (fr) | Procede de preparation d'oxamides . | |
BE896853A (fr) | Procede et dispositif de preparation d'objets creux en matiere ceramique. | |
FR2533439B1 (fr) | Nouvelles compositions pharmaceutiques a base de cis-platine-ii-diammino-dichlorure et procede pour les preparer | |
BE894925A (fr) | Nouvelle substance ch-1 a activite physiologique et son procede d'obtention | |
FR2505330B1 (fr) | Nouvelle substance carcinostatique a base d'un derive de n-(4-(3-aminopropyl) aminobutyl)-2-((s)-7-guanidino-3-hydroxyhaptanamido)-2-hydroxyethanamide et son procede de preparation | |
PT76853A (fr) | Procede de preparation de compositions pharmaceutiques a base de xylosides et lyxosides de base puriques et pyrimidiques | |
FR2666334B1 (fr) | Procede continu de preparation d'acrylamides et de methacrylamides n-substitues. | |
FR2523131B1 (fr) | N-(8a-ergolinyl)-n', n'-diethylurees substituees en 1 et procede d'obtention de ces composes | |
PT75949B (fr) | Procede pour la preparation de derives d'acides amines en n-(vinblastinoil-23) | |
MA18628A1 (fr) | Procede d'obtention de nouvelles compositions pharmaceutiques a base d'aryltrigluoroethanol | |
FR2644161B1 (fr) | Procede de preparation d'amides n-arylsubstitues | |
FR2585574B1 (fr) | Nouvelles compositions pharmaceutiques anti-glaucomateuses a base de 1,4-dihydropyridines et leur procede d'obtention | |
MA22051A1 (fr) | Procede d'obtention d'une formulation pharmaceutique | |
FR2510991B1 (fr) | Procede pour la preparation de methacrylamides et d'acrylamides n-substitues | |
BE893117A (fr) | Procede d'halogenation de n-(0,0'-dialkyl phenyl) alaniates et homologues) | |
IT1156324B (it) | Metodo per la preparazione di catalizzatori supportati e catalizzatori supportati cosi' ottenuti | |
PT75155B (fr) | Procede de preparation d'ethylamines beta-cyclo-substituees | |
IT8248390A0 (it) | N-[4-(3-amminopropil)amminobutil]2,2-diidrossiotanammide come immuno -stimolante ed intermedio per laproduzione di sostanze carcinostati che, e procedimento per la sua preparazione | |
FR2598083B1 (fr) | Nouvelles compositions pharmaceutiques a action antiprogesteronique et leur procede d'obtention | |
FR2601955B1 (fr) | Procede de preparation d'alkyl et d'arylchlorosilane | |
FR2595353B1 (fr) | Procede de preparation d'encainide | |
RO82040A2 (fr) | Bislactames n-substitus et procede d'obtention | |
RO83540A2 (fr) | Alliage de silicium amcrphe et procede d'obtention | |
RO85547A2 (fr) | Derive de meclophenoxate et procede d'obtention | |
RO93008A2 (fr) | Copolymeres en base de cicyclopentadiene et procede d'obtention |