FR24C1025I1 - COMPOSITIONS AND METHODS OF TREATMENT OF ANEMIA - Google Patents

COMPOSITIONS AND METHODS OF TREATMENT OF ANEMIA

Info

Publication number
FR24C1025I1
FR24C1025I1 FR24C1025C FR24C1025C FR24C1025I1 FR 24C1025 I1 FR24C1025 I1 FR 24C1025I1 FR 24C1025 C FR24C1025 C FR 24C1025C FR 24C1025 C FR24C1025 C FR 24C1025C FR 24C1025 I1 FR24C1025 I1 FR 24C1025I1
Authority
FR
France
Prior art keywords
anemia
compositions
treatment
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR24C1025C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akebia Therapeutics Inc
Original Assignee
Akebia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akebia Therapeutics Inc filed Critical Akebia Therapeutics Inc
Publication of FR24C1025I1 publication Critical patent/FR24C1025I1/en
Active legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1816Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR24C1025C 2013-06-13 2024-06-07 COMPOSITIONS AND METHODS OF TREATMENT OF ANEMIA Active FR24C1025I1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361834808P 2013-06-13 2013-06-13
US201361889478P 2013-10-10 2013-10-10
US201361898885P 2013-11-01 2013-11-01
US201361898890P 2013-11-01 2013-11-01
US201361912185P 2013-12-05 2013-12-05
PCT/US2014/040889 WO2014200773A2 (en) 2013-06-13 2014-06-04 Compositions and methods for treating anemia

Publications (1)

Publication Number Publication Date
FR24C1025I1 true FR24C1025I1 (en) 2024-07-26

Family

ID=52022903

Family Applications (1)

Application Number Title Priority Date Filing Date
FR24C1025C Active FR24C1025I1 (en) 2013-06-13 2024-06-07 COMPOSITIONS AND METHODS OF TREATMENT OF ANEMIA

Country Status (35)

Country Link
US (2) US11857543B2 (en)
EP (2) EP4360706A3 (en)
JP (5) JP2016521747A (en)
KR (4) KR20240055172A (en)
CN (3) CN114404413A (en)
AU (4) AU2014278543B2 (en)
BR (1) BR112015031027A2 (en)
CA (2) CA2914662C (en)
CL (2) CL2015003602A1 (en)
DK (1) DK3007695T3 (en)
DO (1) DOP2015000297A (en)
EC (1) ECSP20058592A (en)
ES (1) ES2974273T3 (en)
FI (2) FI3007695T3 (en)
FR (1) FR24C1025I1 (en)
HK (1) HK1216844A1 (en)
HR (1) HRP20240319T1 (en)
HU (2) HUE066123T2 (en)
IL (3) IL243047B (en)
LT (1) LT3007695T (en)
MX (3) MX2015017229A (en)
NL (1) NL301278I2 (en)
NO (1) NO2024025I1 (en)
NZ (3) NZ714963A (en)
PE (2) PE20201496A1 (en)
PH (2) PH12015502738B1 (en)
PL (1) PL3007695T3 (en)
PT (1) PT3007695T (en)
RS (1) RS65341B1 (en)
RU (2) RU2705206C2 (en)
SG (2) SG10201910773VA (en)
SI (1) SI3007695T1 (en)
TW (3) TWI712411B (en)
WO (1) WO2014200773A2 (en)
ZA (1) ZA201509024B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3026044T3 (en) 2006-06-26 2019-04-30 Akebia Therapeutics Inc Prolyl hydroxylase inhibitors and methods of use
NO2686520T3 (en) 2011-06-06 2018-03-17
JP6608355B2 (en) 2013-04-16 2019-11-20 コーニンクレッカ フィリップス エヌ ヴェ System and method for biventricular pacemaker pulse detection in surface ECG
JP2016521747A (en) * 2013-06-13 2016-07-25 アケビア セラピューティクス インコーポレイテッドAkebia Therapeutics Inc. Compositions and methods for the treatment of anemia
MA39033A1 (en) 2013-11-15 2017-11-30 Akebia Therapeutics Inc Solid forms of {[5- (3-chlorophenyl) -3-hydroxypyridine-2-carbonyl] amino} acetic acid, compositions and uses thereof
TW201632504A (en) 2015-01-23 2016-09-16 阿克比治療有限公司 Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
JP6929785B2 (en) * 2015-04-01 2021-09-01 アケビア セラピューティクス インコーポレイテッドAkebia Therapeutics Inc. Compositions and methods for the treatment of anemia
CN108401429A (en) * 2016-12-06 2018-08-14 深圳市塔吉瑞生物医药有限公司 A kind of substituted heteroaryl amide compounds and the composition and application thereof comprising the compound
WO2019028150A1 (en) * 2017-08-01 2019-02-07 Akebia Therapeutics, Inc. Compositions for use in methods of treatment of hemoglobin disorders
AU2019265629B2 (en) 2018-05-09 2024-09-12 Akebia Therapeutics, Inc. Process for preparing 2-((5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl)amino)acetic acid
AU2020374963A1 (en) 2019-10-31 2022-06-09 Akebia Therapeutics, Inc. Therapeutic methods using vadadustat
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
CN115279342A (en) * 2020-03-17 2022-11-01 兹杜斯生命科学有限公司 Formulations comprising HIF prolyl hydroxylase inhibitors
CA3181403A1 (en) * 2020-04-29 2021-11-04 BioAge Labs, Inc. Hypoxia-inducible factor prolyl hydroxylase inhibitors for treating aging-related conditions
EP4181873A1 (en) 2020-06-19 2023-05-24 Akebia Therapeutics Inc. Modulation of drug-drug interactions of vadadustat
JP2024503377A (en) 2021-01-08 2024-01-25 アケビア セラピューティクス インコーポレイテッド Treatment methods using Vadadustat
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
IL305487A (en) 2021-03-01 2023-10-01 Akebia Therapeutics Inc Modulation of drug-drug interactions of vadadustat

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655679A (en) 1969-06-25 1972-04-11 Merck & Co Inc Certain aryl pyridine carboxylic acid derivatives
US3703582A (en) 1970-04-20 1972-11-21 Merck & Co Inc Aryl pyridine carboxylic acids in the treatment of inflammation
US3894920A (en) 1971-12-21 1975-07-15 Sagami Chem Res Process for preparing alkyl-substituted 3,6-dihydro-o-dioxin derivatives
US4016287A (en) 1972-07-17 1977-04-05 Boehringer Ingelheim Gmbh Dermatological compositions containing an acylamino-carboxylic acid or an alkyl ester thereof
CA1261335A (en) * 1984-08-29 1989-09-26 Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee Ethylenediamine monoamide derivatives
CN1023479C (en) 1985-09-27 1994-01-12 弗·哈夫曼-拉罗切有限公司 Process for preparing monoamide derivatives of ethylenediamine
TW219933B (en) 1990-02-26 1994-02-01 Lilly Co Eli
US5405613A (en) 1991-12-11 1995-04-11 Creative Nutrition Canada Corp. Vitamin/mineral composition
TW352384B (en) 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
DE4219158A1 (en) 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenyl derivatives, pharmaceutical compositions containing them and processes for their preparation
DE59401924D1 (en) 1993-11-02 1997-04-10 Hoechst Ag Substituted heterocyclic carboxamides, their preparation and their use as medicines
EP0650960B1 (en) 1993-11-02 1997-03-05 Hoechst Aktiengesellschaft Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments
CA2138929A1 (en) 1993-12-30 1995-07-01 Klaus Weidmann Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
DE4410423A1 (en) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridin-2-carboxamides and their pyridine N-oxides, processes for their preparation and their use as medicaments
DE4410480A1 (en) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridine-2-carboxylic acid ester amides and their pyridine N-oxides, processes for their preparation and their use as medicaments
US5789426A (en) 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
DE19535571A1 (en) * 1995-09-14 1997-03-20 Boehringer Mannheim Gmbh Combined pharmaceutical preparations and their use for the treatment of hemodialysis patients
IL135495A (en) 1995-09-28 2002-12-01 Hoechst Ag Intermediate compounds for the preparation of substituted quinoline-2-carboxylic acid amides
JPH09221476A (en) 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd Medicinal composition
WO1997041103A1 (en) 1996-04-30 1997-11-06 Hoechst Aktiengesellschaft 3-alkoxypyridine-2-carboxylic acid amide esters, their preparation and their use as drugs
DE19620041A1 (en) 1996-05-17 1998-01-29 Merck Patent Gmbh Adhesion receptor antagonists
DE19650215A1 (en) 1996-12-04 1998-06-10 Hoechst Ag 3-hydroxypyridine-2-carboxylic acid amide esters, their preparation and their use as medicaments
CN1282319A (en) 1997-10-09 2001-01-31 小野药品工业株式会社 Aminobutanoic acid derivatives
DE19746287A1 (en) 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituted isoquinoline-2-carboxylic acid amides, their preparation and their use as medicaments
WO1999048870A1 (en) 1998-03-23 1999-09-30 Aventis Pharmaceuticals Products Inc. Piperididinyl and n-amidinopiperidinyl derivatives
GB9809213D0 (en) * 1998-04-29 1998-07-01 Glaxo Group Ltd Pharmaceutical compositions
PL200163B1 (en) 1998-06-11 2008-12-31 Upjohn Co Delavirdine tablet formulation
US6159379A (en) 1999-05-04 2000-12-12 Baker Hughes Incorporated Organic ammonium salts for the removal of water soluble organics in produced water
JP2001048786A (en) 1999-08-05 2001-02-20 Yamanouchi Pharmaceut Co Ltd Tricyclic heteroaryl derivative
US6589758B1 (en) 2000-05-19 2003-07-08 Amgen Inc. Crystal of a kinase-ligand complex and methods of use
CA2725833A1 (en) * 2001-01-12 2002-07-18 Sun Pharmaceutical Industries Limited Spaced drug delivery system
US6849718B2 (en) 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
US6855510B2 (en) 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
EP1379630B1 (en) 2001-03-21 2012-09-26 Isis Innovation Limited Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
SE0101327D0 (en) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
US6566088B1 (en) 2001-10-04 2003-05-20 Board Of Regents, The University Of Texas System Prolyl-4-hydroxylases
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
WO2003049686A2 (en) 2001-12-06 2003-06-19 Fibrogen, Inc. Stabilization of hypoxia inducible factor (hif) alpha
CN1668296A (en) 2002-05-17 2005-09-14 细胞基因公司 Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
WO2003101431A1 (en) * 2002-06-04 2003-12-11 J.B. Chemicals & Pharmaceuticals Ltd. Pharmaceutical composition for controlled drug delivery system
BR0313239A (en) 2002-08-29 2005-06-14 Merck & Co Inc Compound, pharmaceutical composition, and methods of treating or preventing pain and inflammation and disease
CA2502541A1 (en) 2002-10-16 2004-04-29 Isis Innovation Limited Asparaginyl hydroxylases and modulators thereof
EP1567528A1 (en) 2002-11-21 2005-08-31 Eli Lilly And Company Mixed lineage kinase modulators
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7183287B2 (en) 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones
US20060251638A1 (en) 2003-06-06 2006-11-09 Volkmar Guenzler-Pukall Cytoprotection through the use of hif hydroxylase inhibitors
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
CN102718708A (en) 2003-06-06 2012-10-10 菲布罗根有限公司 Novel nitrogen-containing heteroaryl compounds and methods of use thereof
GB0314129D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
JP2008500834A (en) 2004-05-28 2008-01-17 ファイブローゲン、インコーポレーテッド HIF prolyl hydroxylase activity assay
EP1771418A2 (en) 2004-05-31 2007-04-11 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
KR20070083484A (en) 2004-07-14 2007-08-24 피티씨 테라퓨틱스, 인크. Methods for treating hepatitis c
TW200616969A (en) 2004-09-17 2006-06-01 Tanabe Seiyaku Co Imidazole compound
US20080213404A1 (en) 2005-02-04 2008-09-04 Johnson Randall S Hif Modulating Compounds and Methods of Use Thereof
DE102005019712A1 (en) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone and its use
WO2006133391A2 (en) 2005-06-06 2006-12-14 Fibrogen, Inc. Improved treatment for anemia using a hif-alpha stabilising agent
EP1919463B9 (en) 2005-06-15 2011-02-02 Fibrogen, Inc. Use of hif 1alfa modulators for treatment of cancer
CN101262847B (en) 2005-09-12 2010-11-24 埃科特莱茵药品有限公司 Stable pharmaceutical composition comprising a pyrimidine-sulfamide
WO2007033216A2 (en) 2005-09-12 2007-03-22 Beth Israel Deaconess Medical Center Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
WO2007038571A2 (en) 2005-09-26 2007-04-05 Smithkline Beecham Corporation Prolyl hydroxylase antagonists
US20090176726A1 (en) 2005-10-11 2009-07-09 Fisher David E Methods for treating mitf-related disorders
CA2634168C (en) 2005-12-09 2013-04-23 Amgen Inc. Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof
JP2009522383A (en) 2006-01-09 2009-06-11 ビーティージー・インターナショナル・リミテッド Hypoxia-inducible factor-1 modulators and related uses
EP1983823A1 (en) 2006-01-17 2008-10-29 VIB vzw Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration
CA2635899A1 (en) 2006-01-19 2007-07-26 Osi Pharmaceuticals, Inc. Fused heterobicyclic kinase inhibitors
JP4801451B2 (en) 2006-01-19 2011-10-26 株式会社日立ハイテクノロジーズ Control device and control method for electron gun used in scanning electron microscope and the like
ITMI20060179A1 (en) 2006-02-02 2007-08-03 Abiogen Pharma Spa PROCEDURE FOR RESOLUTION OF RACEMIC MIXTURES AND DIASTEREOISOMERIC COMPLEX OF A SOLVING AGENT AND UNANTIOMER OF INTEREST
WO2007101204A1 (en) 2006-02-27 2007-09-07 Alcon Research, Ltd. Method of treating glaucoma
TW200808793A (en) 2006-03-07 2008-02-16 Smithkline Beecham Corp Prolyl hydroxylase inhibitors
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
WO2007136990A2 (en) 2006-05-16 2007-11-29 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
KR100798730B1 (en) * 2006-06-12 2008-01-29 신풍제약주식회사 Controlled release formulation containing loxoprofen or zaltoprofen and process for the preparation thereof
JO2934B1 (en) 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl Hydroxylase Inhibitors
PL3026044T3 (en) 2006-06-26 2019-04-30 Akebia Therapeutics Inc Prolyl hydroxylase inhibitors and methods of use
CA2563690C (en) 2006-10-12 2014-10-07 Pharmascience Inc. Pharmaceutical compositions comprising intra- and extra- granular fractions
GB2444904B (en) 2006-12-05 2008-11-05 Michael Hilary Burke A Process For The Preparation of an Orally Administrable Unit Dose Tablet
CL2008000066A1 (en) 2007-01-12 2008-08-01 Smithkline Beecham Corp COMPOUNDS DERIVED FROM (5-HYDROXY-3-OXO-2,3-DIHYDROPIRIDAZINE-4-CARBONYL) GLYCINE, HIFROXYLASE HYDROXYLASE HIF INHIBITORS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF THE ANEM
CL2008000065A1 (en) 2007-01-12 2008-09-22 Smithkline Beecham Corp COMPOUNDS DERIVED FROM N-SUBSTITUTED GLYCINE, INHIBITORS OF HIF PROLIL HYDROXYLASES; YOUR PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF THE ANEMIA.
EP2134326B1 (en) 2007-04-17 2011-11-16 Ratiopharm GmbH Pharmaceutical compositions comprising irbesartan
CN101663037A (en) 2007-04-18 2010-03-03 默克公司 Novel 1,8-naphthyridine compounds
EP2155680B1 (en) 2007-04-18 2013-12-04 Amgen, Inc Indanone derivatives that inhibit prolyl hydroxylase
ES2389063T3 (en) 2007-05-04 2012-10-22 Amgen, Inc Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity
CA2685942A1 (en) 2007-05-16 2008-11-27 Merck & Co., Inc. Spiroindalones
BRPI0812361A2 (en) 2007-05-18 2015-02-03 Bayer Schering Pharma Ag Heteroaryl PIRAZOL DERIVATIVES SUBSTITUTED FOR THE TREATMENT OF ANGIOGENESE DISORDERS AND HYPERPROLIFERATIVE DISEASES
US8268794B2 (en) 2007-08-06 2012-09-18 Senju Pharmaceutical Co., Ltd. Pharmaceutical containing HIF-1 alpha and HIF-2 alpha expression inhibitor
TW200908984A (en) 2007-08-07 2009-03-01 Piramal Life Sciences Ltd Pyridyl derivatives, their preparation and use
WO2009037570A2 (en) 2007-08-10 2009-03-26 Crystalgenomics, Inc. Pyridine derivatives and methods of use thereof
WO2009035534A2 (en) 2007-09-07 2009-03-19 The Cleveland Clinic Foundation Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif)
WO2009039321A1 (en) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009039323A1 (en) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009043093A1 (en) 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Hif inhibition
WO2009049112A1 (en) 2007-10-10 2009-04-16 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009067790A1 (en) 2007-11-26 2009-06-04 Uti Limited Partnership STIMULATION OF HYPOXIA INDUCIBLE FACTOR -1 ALPHA (HIF-1α) FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE (CDAD), FOR INTESTINAL MOTILITY AND FOR DETECTING INFECTION
WO2009070644A1 (en) 2007-11-30 2009-06-04 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
AU2008331480A1 (en) 2007-11-30 2009-06-11 Glaxosmithkline Llc Prolyl hydroxylase inhibitors
WO2009073669A1 (en) 2007-12-03 2009-06-11 Fibrogen, Inc. Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions
EP2240178A4 (en) 2007-12-19 2011-10-26 Glaxosmithkline Llc Prolyl hydroxylase inhibitors
US20110003013A1 (en) 2008-01-04 2011-01-06 Garvan Institute Of Medical Research Method of increasing metabolism
EP2252619B1 (en) 2008-01-11 2013-10-09 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity
AU2009222105B2 (en) 2008-03-03 2012-05-17 Novartis Ag Compounds and compositions as TLR activity modulators
CN102099335A (en) 2008-07-23 2011-06-15 弗·哈夫曼-拉罗切有限公司 Heterocyclic antiviral compounds
TW201006473A (en) * 2008-08-13 2010-02-16 Orient Pharma Co Ltd Bi-layer medicine tablet containing Zaleplon
BRPI0913485A2 (en) 2008-09-15 2016-06-07 Kasina Laila Innova Pharmaceuticals Private Ltd anticancer medicines and related uses for metastatic malignant melanoma and other cancers.
HU230877B1 (en) * 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stable pharmaceutical combination
CN105037323A (en) 2008-11-14 2015-11-11 菲布罗根有限公司 Thiochromene derivatives as HIF hydroxylase inhibitors
US8137666B2 (en) * 2008-11-22 2012-03-20 Academia Sinica Nattokinase for degrading and reducing amyloid fibrils—associated with alzheimer's disease, prion diseases and other amyloidoses
PT2415771E (en) 2009-03-31 2013-10-03 Kissei Pharmaceutical Indolizine derivative and use thereof for medical purposes
SI3222277T1 (en) 2009-03-31 2021-02-26 Ligand Pharmaceuticals Inc. A biphenylsulfonamide endothelin and angiotensin ii receptor antagonist to treat glomerulosclerosis and iga-induced nephropathy
CN102471337B (en) 2009-07-17 2014-12-10 日本烟草产业株式会社 Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor or erythropoietin production-inducing agent
EP2496082B1 (en) 2009-11-06 2016-10-12 Aerpio Therapeutics, Inc. Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
US20140171465A1 (en) 2011-01-13 2014-06-19 Fibrogen, Inc. Methods For Increasing Reticulocyte Hemoglobin Content
EP3251671A1 (en) 2011-06-06 2017-12-06 Akebia Therapeutics Inc. Compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
NO2686520T3 (en) 2011-06-06 2018-03-17
US20130022974A1 (en) 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
CN104024227B (en) 2011-07-22 2015-12-02 北京贝美拓新药研发有限公司 Suppress crystal formation and the application thereof of the compound of Protocollagen prolyl hydroxylase activity
US11491154B2 (en) 2013-04-08 2022-11-08 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
JP2016521747A (en) * 2013-06-13 2016-07-25 アケビア セラピューティクス インコーポレイテッドAkebia Therapeutics Inc. Compositions and methods for the treatment of anemia
MX2016002014A (en) 2013-08-16 2016-07-21 Ohio State Innovation Foundation Compositions and methods for modulating dna methylation.
MA39033A1 (en) 2013-11-15 2017-11-30 Akebia Therapeutics Inc Solid forms of {[5- (3-chlorophenyl) -3-hydroxypyridine-2-carbonyl] amino} acetic acid, compositions and uses thereof
EP3096617A4 (en) 2014-01-23 2017-09-13 Akebia Therapeutics Inc. Compositions and methods for treating ocular diseases
TW201632504A (en) 2015-01-23 2016-09-16 阿克比治療有限公司 Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
EP3270922A4 (en) 2015-03-20 2018-08-01 Akebia Therapeutics Inc. Deuterium-enriched hypoxia-inducible factor prolyl hydroxylase enzyme inhibitors
JP6929785B2 (en) 2015-04-01 2021-09-01 アケビア セラピューティクス インコーポレイテッドAkebia Therapeutics Inc. Compositions and methods for the treatment of anemia
WO2019028150A1 (en) 2017-08-01 2019-02-07 Akebia Therapeutics, Inc. Compositions for use in methods of treatment of hemoglobin disorders
AU2019355097A1 (en) 2018-10-03 2021-05-27 Akebia Therapeutics, Inc. Benzimidazole derivative for use in the treatment of inflammatory disorders
US11524939B2 (en) * 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Also Published As

Publication number Publication date
EP4360706A2 (en) 2024-05-01
EP3007695A2 (en) 2016-04-20
AU2014278543A1 (en) 2016-01-07
TW201534302A (en) 2015-09-16
NO2024025I1 (en) 2024-05-29
HK1216844A1 (en) 2016-12-09
TWI650126B (en) 2019-02-11
EP3007695A4 (en) 2017-05-31
KR20240055172A (en) 2024-04-26
ES2974273T3 (en) 2024-06-26
US11857543B2 (en) 2024-01-02
KR20160023773A (en) 2016-03-03
RU2016100363A (en) 2017-07-18
FI3007695T3 (en) 2024-03-13
MX2022003510A (en) 2022-05-16
MX2020006963A (en) 2022-03-30
FIC20240023I1 (en) 2024-06-25
IL281058A (en) 2021-04-29
JP6612479B2 (en) 2019-11-27
JP2019163293A (en) 2019-09-26
KR102373245B1 (en) 2022-03-17
IL270335B (en) 2021-03-25
JP6937812B2 (en) 2021-09-22
RU2019134558A (en) 2020-02-20
NZ753905A (en) 2020-07-31
WO2014200773A3 (en) 2015-03-05
SI3007695T1 (en) 2024-04-30
TW202133843A (en) 2021-09-16
DOP2015000297A (en) 2016-03-15
IL243047B (en) 2019-11-28
AU2020200903B2 (en) 2021-11-04
HRP20240319T1 (en) 2024-05-24
CN105451739A (en) 2016-03-30
NL301278I2 (en) 2024-08-01
TW201922244A (en) 2019-06-16
EP3007695B1 (en) 2024-02-07
PH12020551705A1 (en) 2021-11-15
CA2914662A1 (en) 2014-12-18
US20160143891A1 (en) 2016-05-26
NZ714963A (en) 2020-07-31
IL281058B2 (en) 2023-08-01
PE20160194A1 (en) 2016-04-20
PH12015502738A1 (en) 2016-03-07
CA2914662C (en) 2022-05-31
CN114404413A (en) 2022-04-29
PL3007695T3 (en) 2024-07-01
JP2020033369A (en) 2020-03-05
JP2023145717A (en) 2023-10-11
BR112015031027A2 (en) 2017-08-29
SG10201910773VA (en) 2020-01-30
JP7328291B2 (en) 2023-08-16
AU2024205219A1 (en) 2024-09-19
AU2022200570B2 (en) 2024-05-02
PE20201496A1 (en) 2020-12-29
PH12015502738B1 (en) 2016-03-07
DK3007695T3 (en) 2024-03-18
JP2021191773A (en) 2021-12-16
EP4360706A3 (en) 2024-07-10
NZ753904A (en) 2020-07-31
LT3007695T (en) 2024-03-25
RS65341B1 (en) 2024-04-30
TWI791177B (en) 2023-02-01
AU2022200570A1 (en) 2022-02-17
ECSP20058592A (en) 2020-10-30
CA3151685A1 (en) 2014-12-18
HUE066123T2 (en) 2024-07-28
KR102461176B1 (en) 2022-11-01
TW202339743A (en) 2023-10-16
KR20210043760A (en) 2021-04-21
CN114404414A (en) 2022-04-29
PT3007695T (en) 2024-03-07
IL281058B1 (en) 2023-04-01
WO2014200773A2 (en) 2014-12-18
US20240335434A1 (en) 2024-10-10
CL2018002372A1 (en) 2018-12-28
RU2016100363A3 (en) 2018-05-15
RU2705206C2 (en) 2019-11-06
HUS2400023I1 (en) 2024-07-28
MX2015017229A (en) 2016-04-19
JP2016521747A (en) 2016-07-25
CL2015003602A1 (en) 2016-07-29
ZA201509024B (en) 2019-05-29
AU2014278543B2 (en) 2019-11-14
KR102660040B1 (en) 2024-04-24
KR20220151008A (en) 2022-11-11
AU2020200903A1 (en) 2020-02-27
TWI712411B (en) 2020-12-11
SG11201509998WA (en) 2016-01-28

Similar Documents

Publication Publication Date Title
FR24C1025I1 (en) COMPOSITIONS AND METHODS OF TREATMENT OF ANEMIA
MA46481A (en) COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED METHODS
MA43135A (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
MA41119A (en) METHODS OF TREATMENT OF MYELODYSPLASIC SYNDROMES AND SIDEROBLASTIC ANEMIA
MA46954A (en) METHODS OF TREATING INFLAMMATORY CONDITIONS
HK1220980A1 (en) Methods and compositions for treatment of pompe disease
DK2968208T3 (en) TREATMENT OF CATAPLEXIA
GB201320723D0 (en) Composition and methods of treatment
HK1222398A1 (en) Compositions and methods for the treatment of burkholderia infections
EP2958936A4 (en) Methods and compositions for treatment of forbes-cori disease
DK2846809T3 (en) TREATMENT OF MYELOSUPPRESSION
BR112015021755A2 (en) antimicrobial and antibiofilm compositions and methods of applying them
DK3626270T3 (en) TREATMENT OF CARDIOVASCULAR DISEASES
FR3009208B1 (en) HEAD OF DISTRIBUTION AND APPLICATION
MA48730A (en) COMPOSITIONS AND METHODS OF TREATMENT OF SYNUCLEINOPATHIES
CL2015000712A1 (en) Method of preparation and application of an organosilicon composition
FR20C1044I2 (en) TRIAZINES FOR THE TREATMENT OF PROTOZOIC INFECTIONS
FI20135866L (en) MICROBIOLOGICAL PROCESSING OF KERATIN
PL3082845T3 (en) Methods and compositions for treatment of peripheral neuropathies
FR3015285B1 (en) FORMULATION FOR THE TREATMENT OF HAIR
MA40687A (en) VASCULAR MALFORMATION TREATMENT METHODS AND COMPOSITIONS
EP2958591A4 (en) Methods and compositions relating to the treatment of cancer
HK1217715A1 (en) Compositions and methods for treatment of stroke
PL3079684T3 (en) Compositions and methods for the treatment of diseases related to the renin-angiotensin-system
FI20136136A (en) Process for the preparation of cosmetic compositions, cosmetic compositions and their use