FR2462159A1 - Strengthening and revitalising brittle finger nails - using an inorganic or organic salt of benzyl-2-thio:ethylamine - Google Patents

Abstract

Brittle and damaged nails can be strengthened and revitalised by the use of at least one salt (I) of an inorganic or organic acid with benzyl-2-thiothylamine of formula C6H5-CH2-S-CH2-CH2-NH2 (II). The treated nails are stronger and have a healthier appearance.

Description

The present invention relates to the use of certain active compounds for the strengthening and revitalization of fragile or altered nails, and in particular nails which tend to crack or split.

 It is well known that the nails, in particular of the nails, frequently have structural and consistency defects, which can be of very diverse origins and in particular linked to the internal functioning of the individual, under his conditions of life, his diet, his age, his state of fatigue or overwork, but these defects can also appear under the effect of eroding actions, for example following prolonged and / or repeated exposures detergents, solvents, especially household chemicals.

 These defects in structure and consistency have the effect of making the surface of the nails unsightly, which can have certain repercussions on the psyche of the person affected by it and can also cause certain physical inconveniences from discomfort to irritation and possibly pain.

 In order to treat the nails, so as to strengthen and revitalize them, various types of compositions have already been proposed based on certain active products.

These compositions are essentially based on the utility station, on the one hand, formalin or .N-methylol derivatives, and, on the other hand, cysteine derivatives and in particular S-carboxymethylcysteine.

 The use of formalin-based hardening compositions in order to exert a crosslinking action on proteins presents a certain risk, given the potential reactivity of formalin vis-à-vis the skin. It therefore follows phenomena of intolerance and the application of such compositions presents risks of sensitization and this all the more so since in this type of composition it is necessary to use relatively high concentrations of formaldehyde to obtain results. satisfactory.

 The compositions based on S-carboxymethylcysteine would act trophically on the nail by providing it with cysteine, one of the eighteen amino acids which enters the polypeptide chain of the nail keratin structure.

 However, if it has been possible to observe certain results with this type of composition, these are not entirely satisfactory, in particular as regards the strengthening of the nails which tend to split.

after numerous researches in different classes of sulfur compounds, it has been found that the drawbacks of the various compositions used up to now can be remedied and, moreover, obtain excellent results in the strengthening and revitalization of fragile or damaged nails , by using in suitable compositions certain sulfur-containing organic compounds which until now had never been recommended in this type of compositions.

Indeed, after numerous tests on women's nails, fragile or damaged, it turned out that a significant reinforcement, thus making it possible to return to the nails a healthier appearance, was obtained by using certain salts of benzyl thio- 2 ethylamine.

The present invention relates to the use, for the strengthening and revitalization of fragile or damaged nails of at least one salt of a mineral or organic acid of 2-benzylthio-ethylamine of formula
C6H5 - CH2 - S - CH2 - CH2 - NH2 (I)
said mineral acid preferably being hydrochloric acid, hydrobromic acid or phosphoric acid and said organic acid preferably being malic, tartaric, salicylic, succinic, aspartic, glutamic, maleic, fumaric acid or amino acid -5 thia-3 hexanedioic.

The active compounds as used according to the present invention are known and have already been described several times in the literature, in particular in certain prior patents of the applicant company.

Among the compounds corresponding to the formula (Ir above which can be used with advantage according to the invention, mention may in particular be made of 2-benzylthio-ethyl hydrochloride
Amine, 2-benzylthio-ethylammonium malate, 2-benzylthio-ethylammonium tartrate, 2-benzylthio-ethyl ammqnium aspartate, 2-benzylthio-2-ethylammonium glutamate and 5-amino 3-benzylthio-2-hexanedioate ,
The active compounds as defined above are generally used as a mixture in a cosmetic vehicle suitable for nail application and are present in a proportion of between 0.05 and 5% by weight, and preferably between 0.2 and 2% in weight.

The compositions based on the active compounds according to the invention are preferably in the form of emulsions of the water-in-oil or oil-in-water type.

When the emulsions are of the oil-in-water type, these preferably contain
from 2 to 14% by weight of a polyoxyethylene ester and in particular of stearate,
from 0.5 to 3% by weight of a glyceryl ester and in particular of mono and glyceryl distearate,
and - from 2 to 9% by weight of a fatty alcohol and in particular cetyl alcohol.

These compositions in the form of oil-in-water emulsions can also contain isopropyl palmitate (up to 20%), ethyldiglycol (up to 20%), oils such as petrolatum oil, silicone oil, or vegetable oil (up to 7%).

These emulsions may also contain from 1 to 20% by weight of hydrogenated palm kernel oil or between 0.2 to 0.5 * by weight of a polymethacrylic acid such as that sold under the trade name of CARBOPOL by the company GOODRICH .

When the emulsions are of the water-in-oil type, these preferably contain
- from 2 to 40% by weight of paraffin oil,
- from 2 to 30% by weight of glycerin,
and - from 1 to 40% by weight of a mixture of paraffinic hydrocarbons, of mono and diglycerides, of aliphatic alcohols and of sterols, and in particular the mixture sold under the trade name of "Protegin X" by the company GOLDSCHMIDT .

This product "Protegin X" has the following composition - Paraffinic Hydrocrrubides of structure
partially microcrystalline about 53% - Partial esters of fatty acids and glycerol "25% - Aliphatic alcohols, '" 5% - Terpenes ...................... ................ "10 # - Steroids ............................. ........ "7%
These water-in-oil type emulsions can also contain magnesium sulfate (hydrated) in a proportion of between 0.1 and 3% by weight.

Although the emulsions constitute the preferred embodiment of the compositions according to the invention, these can also be in the form of hydroalcoholic solutions in which the proportion of alcohol (ethanol or isopropanol) is between 10 and 70% by weight .

dans laquelle : M représente soit une liaison covalente et le composé peut se présenter sous forme d'un complexe, soit un reste divalent de formule

dans laquelle : R représente un radical alkyle de 1 à 4 atomes de carbone, un radical 8-aminoéthyle, un radical amino-2 carboxy-2 éthyle, un radical phényle, un radical phényle substitué par un alkyle ayant de 1 à 3 atomes de carbone, un hydroxyle ou un halogène, ou R représente le radical oxo-2 bornanyl-l0.According to this embodiment, the composition also preferably contains from 0.5 to 5% by weight of at least one compound of formula

in which: M represents either a covalent bond and the compound can be in the form of a complex, or a divalent residue of formula

in which: R represents an alkyl radical of 1 to 4 carbon atoms, an 8-aminoethyl radical, a 2-amino-2-carboxy-ethyl radical, a phenyl radical, a phenyl radical substituted by an alkyl having from 1 to 3 carbon atoms carbon, a hydroxyl or a halogen, or R represents the 2-oxo bornanyl-10 radical.

 When - in the compound of formula (II) above, the radical M represents a covalent bond, that is to say corresponds to dithio-2,2 'bis (pyridine N-oxide), this compound can be used according to the invention in the form of a complex with a metal salt such as for example calcium chloride or magnesium sulfate. Such complexes are described in French patent No. 72.36766 (U.S. Patent 3,818,018).

 Among the compounds of formula (II) which can be used according to the invention, mention may be made of dithio-2,2 'bis- (pyridine-Noxide), bis- (N-oxypyridyl-2) aluminum camphosulfate, p bis (N-oxypyridyl-2) aluminum toluene sulfonate, bis- (N-oxypyridyl-2) aluminum methane sulfonate, bis- (N-oxypyridyl-2) aluminum B-amino ethane sulfonate, and amino-2 -carboxy-2 ethane sulfonate bis (N-oxypyridyl-2) aluminum.

Of course, the compositions, whether these are in the form of emulsions or hydroalcoholic solutions, can contain a mixture of various other types of compounds and in particular sorbitol, propylene glycol, a polyethylene glycol of molecular weight between 200 and 1500, antioxidants, dyes, pigments, preservatives, unsaponifiables extracted from vegetable oils, perfumes, soluble proteins (gelatin, collagen, soluble keratin), amino acids or hydrolysates of proteins and vitamins such as A, D3, E,
F, B, and C.

Another subject of the present invention is the method for strengthening the nails, this method consisting in applying regularly to the surface of the nail a composition as defined above using a brush.

In order to obtain a lasting effect, it is recommended to apply the compositions according to the invention daily and preferably in the evening so that the action can be prolonged overnight.

After drying, it is possible, if desired, to apply a colorless or colored nail varnish, the adhesion of the film to the nail being excellent.

 In order to better understand the invention, we will now give by way of illustration and without any limiting character several examples of nail strengthening compositions according to the invention.

EXSWPLES-OF COMPOSITIONS
A- Oil-in-water problems
EXAMPLE 1 Polyoxyethylene stearate with
20 moles of ethylene oxide (20 / EO) 3 g - Mono and glycerol distearate .. 0.6 g - Cetyl alcohol .................... .............. 2 g - Wheat germ oil ............................ 7 g - Vaseline oil 8 g - Carbopol ....................................... ... 0.2 g - Triethanolamine qs .................... pH 6 - 2-Benzylthio-ethylammonium malate 2 g - Water qs ...... ................................... 100 g
By daily application of this emulsion, there is a remarkable improvement in the general condition of brittle nails after a few weeks.

EXAMPLE 2 - Polyoxyethylene stearate at 20 / OE 8.25 g - Mono and glycerol distearate 1.5 g - Cetyl alcohol 5.25 g - Isopropyl palmitate - 4 g - Inter hydrogenated palm kernel oil
esterified 5 g - Ethyl diglycol .................................... 5 g - Camphosulfonate bis- ( N-oxypyridyl-2)
aluminum 0.1 g - 2-Benzylthio-ethylammonium malate ....... 1.5 g - Perfume ......................... ................... 0.2 g - Water qs ........................ .......... 100 g EXAMPLE 3 - Polyoxyethylene stearate at 20 / EO 6 g - Mono and glycerol distearate .................... 1.2 g - Cetyl alcohol 4 g - Sunflower oil 5 g - Silicone oil 4 g - Palm kernel oil 3 g - Benzylthio-2 ethylammonium aspartate. 2 g - Preservative 0.3 g - Water qs ....................................... ... 100 g
EXAMPLE 4 - Polyoxyethylene stearate at 20 / EO 3 g - Mono and glycerol distearate 0.6 g - Cetyl alcohol 2 g - Sunflower oil 7 g - Vaseline oil 8 g - Carbopol ......... ................................. 0.2 g - Triethanolamine qs .......... .............. pH 6 - Amino-5 thia-3 benzyl hexanedioate
2-thio ethylammonium 2.5 g - Pyridoxine camphosulfonate 0.9 g - Preservative ................................. ...... 0.2 g - Perfume ...................................... ....... 0.3 g - Water qs .................................... .... 100 g
EXAMPLE 5 Polyoxyethylene stearate at 2Q / EO 8.25 g - Mono and glycerol distearate ..................... 1.5 g - Cetyl alcohol 5.25 g - Isopropyl palmitate 4 g - Inter hydrogenated palm kernel oil
esterified 5 g - Ethyl diglycol ..................................... 5 g - Preservative 0.3 g - Benzylthio-2 ethylammonium malate 5 g - Fragrance ...................................... ......... 0.3 g - Water qs .................................. .. 100 g
B - water-in-oil emulsions
EXAMPLE 6 - Protegin X ........................................... 20 g - Paraffin oil 10 g - Glycerol .......................................... .... 5 g - Hydrated magnesium sulfate .......................... 0.5 g - 2-Benzylthio-ethylammonium malate. 2 g - Water qs ................................... 100 g
EXAMPLE 7 - Protegin X ~ 10 g - Paraffin oil 20 g - Glycerol .................................. ........... 10 g - Magnesium sulphate 2 g - Benzylthio-2 ethylammonium tartrate 1.5 g - Soy unsaponifiables 0.2 g - Water qs ........ ........................... 100 g
EXAMPLE 8 - Protegin X ........................................... 30 g - Paraffin oil 5 g - Glycerol .......................................... ... 5 g
Magnesium sulphate 1 g Benzylthio-2 ethylammonium glutamate 3 g - Water qs .................................. ......... 100 g
EXAMPLE 9 - Protegin X o 20 g - Paraffin oil 10 g - Glycerol .................................. ........... 5 g - Magnesium sulfate ................................. 0.5 g - Amino-5 thia-3 hexanedioate
2-benzylthio-ethylammonium 2 2 g - Vitamin A D3E-Biotin ............................... 0.1 g - Water qs .......................................... 100 g
EXEEPLE 1Q - Protegin XO 20 g - Paraffin oil ................................... 10 g - Glycerol ............................................. 5 g - Dithio complex -2.2 'bis (pyridine
N-oxide) magnesium sulphate ..................... 0.1 g - Benzylthio-2-ethylarnmonium malate 1.8 g - Vitamin F .... ................................... 0.8 g - Vitamin A D3E-Biotin 0.1 g - Water qs .................................... 100 g
C - Hydroalcoholic solutions
EXAMPLE 11 2-Benzylthio-ethylammonium malate 2 g - Bis (N-oxypyridyl-2) camphosulfonate
aluminum 0,05g - Polyethylene glycol 600 ............................ 2 g - Sorbitol ........... ............................... 4 g - Vitamin F .............. .......................... 0.8 g - Unsaponifiables of alfalfa 0.2 g - fragrance .......... .................................. 0.3 g - Ethanol at 70 qs ....... .................... 100 g
EXAMPLE 12 Amino-5 thia-3 hexanedioate
2-benzylthio-ethylammonium 2 g - 2,2-dithio-bis complex
(pyridine-N-oxide) -magnesium sulfate 0.15g - Soluble keratin ................................ 0 , 5 g - Vitamin A D3E-Biotin ........................ 0.1 g - Perfume ........... .............................. 0.2 g - Ethanol .............. ........................ 15 g - Water qs ..................... ................ 100 g
EXAMPLE 13 2-Benzylthio-ethylammonium tartrate 1.2 g - Dithio-2,2 'bis (pyridine-N-oxide) 0.5 g - Soluble collagen ............... .................. 0.2 g - polyethylene glycol 400 ......................... ... 3 g - Ethanol or isopropanol 30 g - perfume ..................................... ....... 0.4 g - Water qs ................................. 100 g
EXAMPLE 14 - Benzylthio-2 ethylammonium malate 4 g - Dithio-2,2 'bis (pyridine-N-oxide) 0.3 g - Propylene glycol 6 6 g - polyethylene glycol 1500 ............ ................ 1 g - vitamin F ............................. ............ 0.8 g - Butylhydroxyanisole 0.1 g - Butylhydroxytoluene 0.1 g - Perfume .................... .......................... 0.5 g - Ethanol e 45 g - Water qs ............ ........................ 100 g
EXAMPLE 15 - 2-Benzylthio-ethylammonium aspartate 0.8 g - Bis (N-oxypyridyl-2) camphosulfonate
aluminum) 0.2 g - Polyethylene glycol 300 .............................. 1.5 g - Glycerol ..... ....................................... 4 g - Perfume ....... ....................................... 0.15g - Ethanol 9 40 g - Water qs > 100 g
EXAMPLE 16 Benzylthio-2 hydrochloride
ethylamine 1 g - Dithio-2,2 'bis complex (pyridine
N-oxide)
- calcium chloride ............................. 0.2 g - Soluble keratin .......... .......................... 0.5 g - Vitamin AD3E - biotin 0.1 g - Perfume ......... ..................................... 0.2 g - Ethanol ....... ...................................... 15 g - Water qs ....... .................................. 100 g

Claims (14)

R E V s N'D I C A T O N S  1. Use for strengthening and revitalizing fragile or damaged nails of at least one salt of a mineral or organic acid of 2-benzyl-thio-ethylamine of formula  C6H5-CH2-S-CH2-CH2-NH2 (I)  2. Use according to claim 1, characterized in that said mineral acid is hydrochloric acid, hydrobromic acid or phosphoric acid and that said organic acid is malic, tartaric, salicylic, succinic, aspartic acid, glutamic, malelque, fumaric or 5-amino-thia-3 hexanediolque acid. 3. Use according to any one of claims 1 and 2, characterized in that the active compound is 2-benzylthio-ethylamine hydrochloride or malate, tartrate, aspartate, glutamate or 5-amino-thia -3 2-benzylthio-ethylammonium hexanedioate. 4. Composition for strengthening and revitalizing fragile or damaged nails, characterized in that it contains from 0.05 to 5% by weight, and preferably from 0.2 to 2% by weight, in a cosmetic vehicle suitable for nail application of at least one active compound as defined according to claims 1 to 3.  5. Composition according to claim 4, characterized in that the cosmetic vehicle is an emulsion of the oil-in-water type, containing from 2 to 14 by weight of a polyoxyethylene ester, from 0.5 to 3% by weight of a glyceryl ester,  and from 2 to 9% by weight of a fatty alcohol. 6. Composition according to any one of claims 4 and 5, characterized in that it also contains up to 20% by weight of isopropyl palmitate, up to 20% by weight of ethyldiglycol and up to 7% by weight of at least one oil taken from the group consisting of petrolatum oil, silicone oil, and a vegetable oil. 7. Composition according to any one of claims 4 to 6, characterized in that it also contains from 1 to 20% by weight of hydrogenated palm kernel oil. 8. Composition according to any one of claims 4 to 7, characterized in that it also contains 0.2 to 0.5% by weight of a polymethacrylic acid. 9. Composition according to claim 4, characterized in that the cosmetic vehicle is a water-in-oil emulsion, and contains  from 2 to 40% by weight of paraffin oil, from 2 to 30% by weight of glycerin, and from 1 to 40% by weight of a mixture of paraffinic hydrocarbons of mono and di-glycerides, aliphatic alcohols and sterols. 10. Composition according to claim 9, characterized in that it also contains from 0.1 to 3t by weight of magnesium sulfate.  11. Composition according to claim 4, characterized in that the cosmetic vehicle is a hydroalcoholic solution having an alcohol proportion of between 10 and 70% by weight.  12. Composition according to Claim 11, characterized in that it also contains from 0.5 to 5% by weight of at least one compound of formula

 in which: M represents either a covalent bond and the compound can be in the form of a complex, or a divalent residue of formula

in which: R represents an alkyl radical of 1 to 4 carbon atoms, an ss-aminoethyl radical, a 2-amino-2-carboxy-ethyl radical, a phenyl radical, a phenyl radical substituted by an alkyl having from 1 to 3 carbon atoms carbon, a hydroxyl or a halogen, or R represents the 2-oxo bornanyl-10 radical. 13. Composition according to any one of the preceding claims, characterized in that it contains other ingredients such as sorbitol, propylene glycol, a polyethylene glycol of molecular weight between 200 and 15Q0, antioxidants, dyes, pigments, preserves Mateurs, unsaponifiables of vegetable oil extracts, perfumes, soluble proteins, amino acids or protein hydrolysates or vitamins.  14. Method for strengthening and revitalizing fragile or altered nails and in particular nails tending to crack or split, characterized in that it consists in applying to the surface of the nail regularly, a composition according to any one of claims 4 to 13.