FR2449725A1 - METHOD AND REAGENT FOR DETECTING CANCERS - Google Patents

METHOD AND REAGENT FOR DETECTING CANCERS

Info

Publication number
FR2449725A1
FR2449725A1 FR8003660A FR8003660A FR2449725A1 FR 2449725 A1 FR2449725 A1 FR 2449725A1 FR 8003660 A FR8003660 A FR 8003660A FR 8003660 A FR8003660 A FR 8003660A FR 2449725 A1 FR2449725 A1 FR 2449725A1
Authority
FR
France
Prior art keywords
protein
coenzyme
reagent
complex
serum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8003660A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1787179A external-priority patent/JPS55110957A/en
Priority claimed from JP16081379A external-priority patent/JPS5685299A/en
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of FR2449725A1 publication Critical patent/FR2449725A1/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

ON SAIT QU'UN TYPE SPECIFIQUE DE PROTEINE APPELEE PROTEINE DE BUCOVAZ OU PROTEINE B EST PRESENT DANS LA PLUPART DES SERUMS SANGUINS DES SUJETS CANCEREUX. L'INVENTION A POUR OBJET UN PROCEDE PERFECTIONNE POUR DETERMINER LA QUANTITE DE PROTEINE B DANS LE SERUM, PERMETTANT AINSI DE DECELER LA PRESENCE DE CANCER, AINSI QU'UN REACTIF UTILISABLE POUR LA MISE EN OEUVRE DU PROCEDE. LE PROCEDE CONSISTE A ADDITIONNER UN ECHANTILLON DE SERUM D'UNE COENZYME MARQUEE, D'ADENOSINE TRIPHOSPHATE OU UN DE SES SELS, ET D'UN COMPLEXE PROTEINIQUE SYNTHETISANT LA COENZYME A, FAISANT AINSI REAGIR LA COENZYME MARQUEE AVEC LES PROTEINES SERIQUES; A PARTIELLEMENT DENATURER LE COMPLEXE PROTEINE BCOENZYME MARQUEE, ET A DETERMINER LA QUANTITE DU COMPLEXE PARTIELLEMENT DENATURE.A SPECIFIC TYPE OF PROTEIN CALLED BUCOVAZ PROTEIN OR PROTEIN B IS KNOWN IN MOST BLOOD SERUMS OF CANCER SUBJECTS. THE OBJECT OF THE INVENTION IS A PERFECTED PROCESS FOR DETERMINING THE QUANTITY OF PROTEIN B IN THE SERUM, THUS ALLOWING TO DETECT THE PRESENCE OF CANCER, AS WELL AS A REAGENT THAT CAN BE USED FOR IMPLEMENTING THE PROCESS. THE PROCESS CONSISTS OF ADDING A SAMPLE OF SERUM OF A MARKED COENZYME, OF ADENOSINE TRIPHOSPHATE OR ONE OF ITS SALTS, AND OF A PROTEIN COMPLEX SYNTHEIZING COENZYME A, THUS REACTING THE LABEL COENZYME; WITH THE SERIAL PROTEINS; TO PARTIALLY DENATURE THE BRANDED BCOENZYME PROTEIN COMPLEX, AND TO DETERMINE THE QUANTITY OF THE PARTLY DENATURE COMPLEX.

FR8003660A 1979-02-20 1980-02-20 METHOD AND REAGENT FOR DETECTING CANCERS Pending FR2449725A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1787179A JPS55110957A (en) 1979-02-20 1979-02-20 Cancer diagnosis method and reagent
JP16081379A JPS5685299A (en) 1979-12-13 1979-12-13 Method and reagent for cancer diagnosis

Publications (1)

Publication Number Publication Date
FR2449725A1 true FR2449725A1 (en) 1980-09-19

Family

ID=26354454

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8003660A Pending FR2449725A1 (en) 1979-02-20 1980-02-20 METHOD AND REAGENT FOR DETECTING CANCERS

Country Status (3)

Country Link
DE (1) DE3006217A1 (en)
FR (1) FR2449725A1 (en)
GB (1) GB2046902A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026259A1 (en) * 1993-05-12 1994-11-24 Oculon Corporation Chemical prevention or reversal of cataract by phase separation inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2648458A1 (en) * 1976-09-29 1978-03-30 Bucovaz REAGENT FOR THE DIAGNOSIS OF CANCER, ITS PRODUCTION AND APPLICATION
FR2424284A1 (en) * 1978-04-26 1979-11-23 Research Corp LOW MOLECULAR WEIGHT SUBSTANCE SOLUBILIZING COENZYME A AND SYNTHEIZING PROTEIN COMPLEX

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2648458A1 (en) * 1976-09-29 1978-03-30 Bucovaz REAGENT FOR THE DIAGNOSIS OF CANCER, ITS PRODUCTION AND APPLICATION
FR2424284A1 (en) * 1978-04-26 1979-11-23 Research Corp LOW MOLECULAR WEIGHT SUBSTANCE SOLUBILIZING COENZYME A AND SYNTHEIZING PROTEIN COMPLEX

Also Published As

Publication number Publication date
GB2046902A (en) 1980-11-19
DE3006217A1 (en) 1980-09-04

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