FR2447931A1 - NOVEL ANTIBIOTIC NAME AX-127B-1, EFFECTIVE IN PARTICULAR AGAINST POSITIVE AND NEGATIVE-GRAM ORGANISMS, AND ITS MANUFACTURING PROCESS VIA A MICROMONOSPORA GENUS - Google Patents

NOVEL ANTIBIOTIC NAME AX-127B-1, EFFECTIVE IN PARTICULAR AGAINST POSITIVE AND NEGATIVE-GRAM ORGANISMS, AND ITS MANUFACTURING PROCESS VIA A MICROMONOSPORA GENUS

Info

Publication number
FR2447931A1
FR2447931A1 FR8002115A FR8002115A FR2447931A1 FR 2447931 A1 FR2447931 A1 FR 2447931A1 FR 8002115 A FR8002115 A FR 8002115A FR 8002115 A FR8002115 A FR 8002115A FR 2447931 A1 FR2447931 A1 FR 2447931A1
Authority
FR
France
Prior art keywords
nr4porosa
micromporosa
negative
effective
manufacturing process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8002115A
Other languages
French (fr)
Other versions
FR2447931B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of FR2447931A1 publication Critical patent/FR2447931A1/en
Application granted granted Critical
Publication of FR2447931B1 publication Critical patent/FR2447931B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

L'ANTIBIOTIQUE AX-127B-1 EST UN COMPOSE DU TYPE AMINO-GLUCOSIDE ET PRESENTE LES PROPRIETES SUIVANTES: A.SOLUBLE DANS L'EAU, TRES LEGEREMENT SOLUBLE DANS LE METHANOL ET ESSENTIELLEMENT INSOLUBLE DANS LES AUTRES SOLVANTS ORGANIQUES COURANTS; B.POIDS MOLECULAIRE 460; C.FORMULE EMPIRIQUE CHNO; D.SPECTRE IR REPRESENTE PAR LA FIGURE1; E.SPECTRE DE MASSE DONNANT POUR L'ION PARENT UNE VALEUR DE 460,2998; F.SPECTRE DE RESONANCE MAGNETIQUE DU CARBONE PRESENTANT LES BANDES SUIVANTES (D, PPM):23,141,448,972,596,2 29,143,456,073,598,5 34,444,257,881,4150,938,546,860,482,6175,3 IL EST PRODUIT PAR UN MICRORGANISME CHOISI PARMI MICROMONOSPORA PILOSOSPORA NRRL11415, MICROMONOSPORA PILOSOSPORA NRRL11416 ET MICROMONOSPORA PILOSOSPORA NRRL11417 ET LEURS MUTANTS.ANTIBIOTIC AX-127B-1 IS AN AMINO-GLUCOSIDE TYPE COMPOUND AND HAS THE FOLLOWING PROPERTIES: A. WATER-SOLUBLE, VERY SLIGHTLY SOLUBLE IN METHANOL AND ESSENTIALLY INSOLUBLE IN OTHER COMMON ORGANIC SOLVENTS; B. MOLECULAR WEIGHT 460; C. EMPIRICAL FORMULA CHNO; D. IR SPECTRUM REPRESENTED BY FIGURE 1; E. MASS SPECTRUM GIVING FOR THE PARENT ION A VALUE OF 460.2998; F. SPECTRUM OF MAGNETIC RESONANCE OF CARBON PRESENTING THE FOLLOWING BANDS (D, PPM): 23,141,448,972,596,2 29,143,456,073,598,5 34,444,257,881,4150,938,546,860,482,6175,3 IT IS PRODUCED BY A MICRORGANISM P11POROSA MICROMPOROSA MICROMPOROSA 11POROSA P11POROSA MICROMPOROSA NR4POROSA Nr4POROSA11POROSA Nr4POROSA Nr4POROSA Nr4POROSA Nr4POROSA Nr4POROSA Nr. PILOSOSPORA NRRL11417 AND THEIR MUTANTS.

FR8002115A 1979-02-01 1980-01-31 NOVEL ANTIBIOTIC NAME AX-127B-1, EFFECTIVE IN PARTICULAR AGAINST POSITIVE AND NEGATIVE-GRAM ORGANISMS, AND ITS MANUFACTURING PROCESS VIA A MICROMONOSPORA GENUS Granted FR2447931A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US837879A 1979-02-01 1979-02-01

Publications (2)

Publication Number Publication Date
FR2447931A1 true FR2447931A1 (en) 1980-08-29
FR2447931B1 FR2447931B1 (en) 1983-04-01

Family

ID=21731303

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8002115A Granted FR2447931A1 (en) 1979-02-01 1980-01-31 NOVEL ANTIBIOTIC NAME AX-127B-1, EFFECTIVE IN PARTICULAR AGAINST POSITIVE AND NEGATIVE-GRAM ORGANISMS, AND ITS MANUFACTURING PROCESS VIA A MICROMONOSPORA GENUS

Country Status (11)

Country Link
JP (1) JPS55104298A (en)
AR (1) AR221524A1 (en)
AU (1) AU5488280A (en)
BE (1) BE881476A (en)
DE (1) DE3003497A1 (en)
ES (1) ES8103165A1 (en)
FR (1) FR2447931A1 (en)
GB (1) GB2042501B (en)
IT (1) IT1149288B (en)
SE (1) SE8000786L (en)
ZA (1) ZA80373B (en)

Also Published As

Publication number Publication date
DE3003497A1 (en) 1980-08-14
AU5488280A (en) 1980-08-07
JPS55104298A (en) 1980-08-09
AR221524A1 (en) 1981-02-13
FR2447931B1 (en) 1983-04-01
ES488208A0 (en) 1981-02-16
GB2042501B (en) 1983-10-19
IT1149288B (en) 1986-12-03
GB2042501A (en) 1980-09-24
SE8000786L (en) 1980-08-02
ZA80373B (en) 1981-01-28
IT8019606A0 (en) 1980-01-31
ES8103165A1 (en) 1981-02-16
BE881476A (en) 1980-07-31

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