FR2447192A1 - GALENIC FORM WITH EXTENDED RELEASE OF INDOPROFENE - Google Patents

GALENIC FORM WITH EXTENDED RELEASE OF INDOPROFENE

Info

Publication number
FR2447192A1
FR2447192A1 FR7931253A FR7931253A FR2447192A1 FR 2447192 A1 FR2447192 A1 FR 2447192A1 FR 7931253 A FR7931253 A FR 7931253A FR 7931253 A FR7931253 A FR 7931253A FR 2447192 A1 FR2447192 A1 FR 2447192A1
Authority
FR
France
Prior art keywords
indoprofene
extended release
galenic form
micro
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7931253A
Other languages
French (fr)
Other versions
FR2447192B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Adria Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adria Laboratories Inc filed Critical Adria Laboratories Inc
Publication of FR2447192A1 publication Critical patent/FR2447192A1/en
Application granted granted Critical
Publication of FR2447192B1 publication Critical patent/FR2447192B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

IL A ETE DECOUVERT QUE L'ACTIVITE DE L'INDOPROFENE PEUT ETRE CONSIDERABLEMENT PROLONGEE EN PROCEDANT A LA MICRO-ENCAPSULATION DES MICRO-PARTICULES D'INDOPROFENE DANS UN REVETEMENT PROTECTEUR SOLIDE D'UN ETHER CELLULOSIQUE TEL QUE L'ETHYLCELLULOSE. CETTE ACTIVITE PEUT ENCORE ETRE DAVANTAGE PROLONGEE EN METTANT CET INDOPROFENE MICRO-ENCAPSULE SOUS FORME DE COMPRIMES.IT HAS BEEN DISCOVERED THAT THE ACTIVITY OF INDOPROFENE MAY BE CONSIDERABLY PROLONGED BY MICRO-ENCAPSULATION OF INDOPROFENE MICRO-PARTICLES IN A SOLID PROTECTIVE COATING OF A CELLULOSIC ETHER SUCH AS ETHYLCELLULOSE. THIS ACTIVITY CAN BE EXTENDED FURTHER BY PUTTING THIS INDOPROFENE MICRO-ENCAPSULE IN THE FORM OF TABLETS.

FR7931253A 1979-01-25 1979-12-20 GALENIC FORM WITH EXTENDED RELEASE OF INDOPROFENE Granted FR2447192A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US697179A 1979-01-25 1979-01-25

Publications (2)

Publication Number Publication Date
FR2447192A1 true FR2447192A1 (en) 1980-08-22
FR2447192B1 FR2447192B1 (en) 1983-08-19

Family

ID=21723530

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7931253A Granted FR2447192A1 (en) 1979-01-25 1979-12-20 GALENIC FORM WITH EXTENDED RELEASE OF INDOPROFENE

Country Status (6)

Country Link
JP (1) JPS55100314A (en)
CA (1) CA1136548A (en)
DE (1) DE3001797A1 (en)
FR (1) FR2447192A1 (en)
GB (1) GB2041222B (en)
IT (1) IT1129713B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57209223A (en) * 1981-06-19 1982-12-22 Tanabe Seiyaku Co Ltd Microcapsule for intracranial anti hypotension and its production
DK150008C (en) * 1981-11-20 1987-05-25 Benzon As Alfred PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL ORAL POLYDEPOT PREPARATION
WO1991001801A1 (en) * 1989-08-01 1991-02-21 Kanebo, Ltd. Microcapsule, treatment liquid containing microcapsules, and textile structure having microcapsules stuck thereto
ES2064564T3 (en) * 1989-09-21 1995-02-01 American Cyanamid Co PULSE PRESSURE RELEASE SYSTEM OF DAILY UNIT DOSE OF MINOCYCLINE.
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
IE64128B1 (en) * 1990-02-26 1995-07-12 Byrne Rynne Holdings Ltd A pharmaceutical composition
US5262173A (en) * 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155590A (en) * 1962-08-02 1964-11-03 Ncr Co Encapsulation process and its product
BE751815A (en) * 1969-06-12 1970-12-11 Merck & Co Inc SLOW-RELEASING ANTI-INFLAMATORY MEDICINAL PRODUCT
GB2002318A (en) * 1977-08-11 1979-02-21 Tanabe Seiyaku Co Microcapsules

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155590A (en) * 1962-08-02 1964-11-03 Ncr Co Encapsulation process and its product
BE751815A (en) * 1969-06-12 1970-12-11 Merck & Co Inc SLOW-RELEASING ANTI-INFLAMATORY MEDICINAL PRODUCT
US3557279A (en) * 1969-06-12 1971-01-19 Merck & Co Inc Microencapsulation form of an anti-inflammatory drug
GB2002318A (en) * 1977-08-11 1979-02-21 Tanabe Seiyaku Co Microcapsules
FR2399835A1 (en) * 1977-08-11 1979-03-09 Tanabe Seiyaku Co PROCESS FOR PREPARING MICROCAPSULES CONTAINING A PHARMACEUTICAL PRODUCT

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *

Also Published As

Publication number Publication date
JPS55100314A (en) 1980-07-31
GB2041222B (en) 1983-05-11
GB2041222A (en) 1980-09-10
CA1136548A (en) 1982-11-30
IT1129713B (en) 1986-06-11
IT8019430A0 (en) 1980-01-24
FR2447192B1 (en) 1983-08-19
DE3001797A1 (en) 1980-08-07

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Legal Events

Date Code Title Description
ST Notification of lapse