FR2435476A1 - (3)-Azido-methyl-(2,9)-di:oxa-tri:cyclodecane derivs. - with analgesic, antipyretic and antiphlogistic activities - Google Patents

(3)-Azido-methyl-(2,9)-di:oxa-tri:cyclodecane derivs. - with analgesic, antipyretic and antiphlogistic activities

Info

Publication number
FR2435476A1
FR2435476A1 FR7825510A FR7825510A FR2435476A1 FR 2435476 A1 FR2435476 A1 FR 2435476A1 FR 7825510 A FR7825510 A FR 7825510A FR 7825510 A FR7825510 A FR 7825510A FR 2435476 A1 FR2435476 A1 FR 2435476A1
Authority
FR
France
Prior art keywords
derivs
antipyretic
methyl
analgesic
cyclodecane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7825510A
Other languages
French (fr)
Other versions
FR2435476B1 (en
Inventor
Peter Willibrord Thies
Samuel David
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Priority to FR7825510A priority Critical patent/FR2435476A1/en
Publication of FR2435476A1 publication Critical patent/FR2435476A1/en
Application granted granted Critical
Publication of FR2435476B1 publication Critical patent/FR2435476B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The dioxatricyclo-decane derivs. of formula (I) are new pharmaceuticals:- In (I) one of R1 and R2 is H, and the other is OH, acyloxy or carbamoyloxy; or together they are oxo. R3 = alkoxy or aralkoxy. The 10,11- double and bond may also be reduced to produce beta-CH3 substit. They are prepd. from the corresp. 3-halomethyl cpd., by reaction with an alkali azide. (I) are already known as intermediates and are now found to have antipyretic, antiphlogistic and analgesic activities. The cpd., 3-azidomethyl-4 beta-acetoxy-8-methoxy-10 beta-methyl-2,9-dioxatricyclo 4,3,1,03,7 decane has intraperitoneal LD50 in mice of 739 mg/kg and has ED50 in the phenylbenzoquinone writhing test of 10 mg/kg orally c.f. 240 mg/kg for acetylsalicyclic acid.
FR7825510A 1978-09-05 1978-09-05 (3)-Azido-methyl-(2,9)-di:oxa-tri:cyclodecane derivs. - with analgesic, antipyretic and antiphlogistic activities Granted FR2435476A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7825510A FR2435476A1 (en) 1978-09-05 1978-09-05 (3)-Azido-methyl-(2,9)-di:oxa-tri:cyclodecane derivs. - with analgesic, antipyretic and antiphlogistic activities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7825510A FR2435476A1 (en) 1978-09-05 1978-09-05 (3)-Azido-methyl-(2,9)-di:oxa-tri:cyclodecane derivs. - with analgesic, antipyretic and antiphlogistic activities

Publications (2)

Publication Number Publication Date
FR2435476A1 true FR2435476A1 (en) 1980-04-04
FR2435476B1 FR2435476B1 (en) 1983-06-03

Family

ID=9212351

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7825510A Granted FR2435476A1 (en) 1978-09-05 1978-09-05 (3)-Azido-methyl-(2,9)-di:oxa-tri:cyclodecane derivs. - with analgesic, antipyretic and antiphlogistic activities

Country Status (1)

Country Link
FR (1) FR2435476A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2341581A1 (en) * 1976-02-21 1977-09-16 Kali Chemie Pharma Gmbh 2,9-DIOXATRICYCLO (4,3,1,03,7) DECANES AND PROCESS FOR THEIR PREPARATION

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2341581A1 (en) * 1976-02-21 1977-09-16 Kali Chemie Pharma Gmbh 2,9-DIOXATRICYCLO (4,3,1,03,7) DECANES AND PROCESS FOR THEIR PREPARATION

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HW1965 *

Also Published As

Publication number Publication date
FR2435476B1 (en) 1983-06-03

Similar Documents

Publication Publication Date Title
Barco et al. A new, elegant route to a key intermediate for the synthesis of 9 (0)-methanoprostacyclin
NO962524L (en) Conversion of bisnoral alcohol to bisnoraldehyde
GB1212090A (en) Aliphatic diol-diones
FR2435476A1 (en) (3)-Azido-methyl-(2,9)-di:oxa-tri:cyclodecane derivs. - with analgesic, antipyretic and antiphlogistic activities
FR2399838A1 (en) (3)-Azido-methyl-(2,9)-di:oxa-tri:cyclodecane derivs. - with analgesic, antipyretic and antiphlogistic activities
NL7614628A (en) HARDABLE COVER COMPOSITIONS.
PT66916A (en) Process for the preparation of 3-azidomethyl-2.9-dioxatricycle(4,3,1,0,3,7)decanes
GB1363460A (en) Rofluoropregnenes
Stoodley Studies related to penicillins. Part II. The rearrangement of 6-β-aminopenicillanic acid to 2, 3-dihydro-6-methoxycarbonyl-2, 2-di-methyl-1, 4-thiazin-3-one
Pohmakotr et al. Intramolecular acylation of α-sulfinyl carbanions. A simple preparation of 4-oxygenated spiro [4. n] alk-2-ene-1-ones
TW332205B (en) A process for making a clinically efficacious HIV protease inhibitor eliminates one step in its synthesis, by an alternative convergent synthesis using 2(S)-4-picolyl-2-piperazine-t-butyl-carboxamide as an intermediate.
JPS5271448A (en) Synthesis of 2-crotonyloxymethyl-(4r,5r,6r)-4,5,6-trihydroxy-cyclohex- 2-enone
JPS54125606A (en) Preparation of ethylene glycol
GB1212339A (en) Preparation of cyclododecanol
DE50202096D1 (en) Process for the preparation of 5-alkoxy-oxazoles and pyridoxines
Minghu et al. Bis (1-Benzyl-3, 5, 7-Triaza-1-Azoniatricyclo [3.3. 1.13, 7] Decane) Peroxodisulfate: A Mild and Efficient Oxidation of Organic Compounds Under Anhydrous and Aprotic Conditions
Torii et al. Lactone Carboxylic Acids. VI. A Synthesis of α, β-Epoxybutyrolactone via α-Diazolactones
JPS52153980A (en) Synthesis of 2,3-dicyanopyrazine
JPS55147234A (en) Preparation of (+)-2-isopropyl-5-methyl-cyclohexanone
ES8405761A1 (en) Azetidinone derivatives
Kendall et al. TETRAHYDRO-3, 4-FURANDIONE. II. DIOXOLANE AND DIOXANE DERIVATIVES
JPS5289641A (en) Preparation of hydroxybenzoic acid esters
JPS5492949A (en) Production of 3,17-dihydroxypregn-5-ene-29-ine
JPS5285148A (en) Preparation of 2, 6-dioxy-iminocyclohexanone
JPS5337674A (en) Preparation of pyrazinecarbamoylcarboxylic acid

Legal Events

Date Code Title Description
ST Notification of lapse