FR2430424A1 - PROCESS FOR THE PREPARATION OF ACID SALTS (-) CIS-1,2-EPOXYPROPYLPHOSPHONIQUE - Google Patents
PROCESS FOR THE PREPARATION OF ACID SALTS (-) CIS-1,2-EPOXYPROPYLPHOSPHONIQUEInfo
- Publication number
- FR2430424A1 FR2430424A1 FR7916110A FR7916110A FR2430424A1 FR 2430424 A1 FR2430424 A1 FR 2430424A1 FR 7916110 A FR7916110 A FR 7916110A FR 7916110 A FR7916110 A FR 7916110A FR 2430424 A1 FR2430424 A1 FR 2430424A1
- Authority
- FR
- France
- Prior art keywords
- cis
- resolving agent
- acid
- salt
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
Pour préparer les sels d'acide (-)cis-1,2-époxypropylphosphonique avec des bases non toxiques, on transforme par oxydation l'acide cis-1-propénylphosphonique en l'époxyacide racémique correspondant, on ajoute l'agent de dédoublement actif, on alcalinise la suspension obtenue de sel d'acide (-)cis-1,2-époxypropylphosphonique avec l'agent de dédoublement, et, le cas échéant, on prépare le sel de la base voulue à partir de la solution obtenue du sel sodique. L'agent de dédoublement optique est le L(+)-thréo-1-(p-méthylmercaptophényl)-2-amino-1,3-propane-diol. L'acide (-)cis-1,2-époxypropylphosphonique et ses sels avec des bases non toxiques sont largement utilisés, tant en médecine humaine que vetérinaire, pour inhiber le développement de bactéries pathogènes, aussi bien Gram-positives que Gramm-négatives.To prepare the salts of (-) cis-1,2-epoxypropylphosphonic acid with non-toxic bases, the cis-1-propenylphosphonic acid is converted by oxidation to the corresponding racemic epoxyacid, the active resolving agent is added. , the resulting suspension of (-) cis-1,2-epoxypropylphosphonic acid salt is basified with the resolving agent, and, if necessary, the salt of the desired base is prepared from the obtained solution of the salt sodium. The optical resolving agent is L (+) - threo-1- (p-methylmercaptophenyl) -2-amino-1,3-propanediol. (-) cis-1,2-epoxypropylphosphonic acid and its salts with non-toxic bases are widely used, both in human and veterinary medicine, to inhibit the development of pathogenic bacteria, both Gram-positive and Gramm-negative.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT25389/78A IT1097477B (en) | 1978-07-06 | 1978-07-06 | METHOD FOR THE PREPARATION OF SALTS OF (-) CIS-1,2-EPOXYPROPYLPHOSPHONIC ACID |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2430424A1 true FR2430424A1 (en) | 1980-02-01 |
FR2430424B1 FR2430424B1 (en) | 1985-04-12 |
Family
ID=11216556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7916110A Granted FR2430424A1 (en) | 1978-07-06 | 1979-06-22 | PROCESS FOR THE PREPARATION OF ACID SALTS (-) CIS-1,2-EPOXYPROPYLPHOSPHONIQUE |
Country Status (14)
Country | Link |
---|---|
JP (1) | JPS5511575A (en) |
AT (1) | AT373264B (en) |
CA (1) | CA1131648A (en) |
CH (1) | CH640863A5 (en) |
DE (1) | DE2925359C3 (en) |
DK (1) | DK284679A (en) |
ES (1) | ES482227A1 (en) |
FR (1) | FR2430424A1 (en) |
GB (1) | GB2024826B (en) |
GR (1) | GR69597B (en) |
IE (1) | IE48590B1 (en) |
IT (1) | IT1097477B (en) |
NL (1) | NL7905313A (en) |
SE (1) | SE446739B (en) |
-
1978
- 1978-07-06 IT IT25389/78A patent/IT1097477B/en active
-
1979
- 1979-06-09 JP JP7185879A patent/JPS5511575A/en active Pending
- 1979-06-12 CH CH549079A patent/CH640863A5/en not_active IP Right Cessation
- 1979-06-22 FR FR7916110A patent/FR2430424A1/en active Granted
- 1979-06-22 DE DE2925359A patent/DE2925359C3/en not_active Expired
- 1979-06-27 GB GB7922413A patent/GB2024826B/en not_active Expired
- 1979-06-28 AT AT0455279A patent/AT373264B/en not_active IP Right Cessation
- 1979-07-03 GR GR59500A patent/GR69597B/el unknown
- 1979-07-05 SE SE7905874A patent/SE446739B/en not_active IP Right Cessation
- 1979-07-05 ES ES482227A patent/ES482227A1/en not_active Expired
- 1979-07-05 DK DK284679A patent/DK284679A/en not_active Application Discontinuation
- 1979-07-06 CA CA331,340A patent/CA1131648A/en not_active Expired
- 1979-07-06 NL NL7905313A patent/NL7905313A/en not_active Application Discontinuation
- 1979-08-08 IE IE1272/79A patent/IE48590B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
GB2024826A (en) | 1980-01-16 |
ES482227A1 (en) | 1980-04-01 |
NL7905313A (en) | 1980-01-08 |
AT373264B (en) | 1984-01-10 |
DE2925359A1 (en) | 1980-01-24 |
GR69597B (en) | 1982-07-05 |
IE48590B1 (en) | 1985-03-20 |
FR2430424B1 (en) | 1985-04-12 |
DK284679A (en) | 1980-01-07 |
DE2925359B2 (en) | 1980-09-04 |
IT1097477B (en) | 1985-08-31 |
JPS5511575A (en) | 1980-01-26 |
IT7825389A0 (en) | 1978-07-06 |
GB2024826B (en) | 1982-12-01 |
SE446739B (en) | 1986-10-06 |
CA1131648A (en) | 1982-09-14 |
IE791272L (en) | 1980-01-06 |
CH640863A5 (en) | 1984-01-31 |
DE2925359C3 (en) | 1981-08-06 |
SE7905874L (en) | 1980-01-07 |
ATA455279A (en) | 1983-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
TP | Transmission of property | ||
ST | Notification of lapse |