FR2428646A1 - 10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders - Google Patents

10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders

Info

Publication number
FR2428646A1
FR2428646A1 FR7817523A FR7817523A FR2428646A1 FR 2428646 A1 FR2428646 A1 FR 2428646A1 FR 7817523 A FR7817523 A FR 7817523A FR 7817523 A FR7817523 A FR 7817523A FR 2428646 A1 FR2428646 A1 FR 2428646A1
Authority
FR
France
Prior art keywords
vincamine
derivs
bond
disorders
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7817523A
Other languages
French (fr)
Other versions
FR2428646B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Priority to FR7817523A priority Critical patent/FR2428646A1/en
Priority to DE19792922316 priority patent/DE2922316A1/en
Priority to IT23464/79A priority patent/IT1121787B/en
Priority to CH548679A priority patent/CH642655A5/en
Priority to ES481998A priority patent/ES481998A0/en
Priority to GB7920355A priority patent/GB2029405A/en
Publication of FR2428646A1 publication Critical patent/FR2428646A1/en
Application granted granted Critical
Publication of FR2428646B1 publication Critical patent/FR2428646B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Vincamine derivs. of formula (I) and their acid addn. salts are new. In (I) R1 is 2-6C opt. branched alkyl; R2 and R3 together form an additional C-C bond, or are OH and H respectively, R4 and R5 together form an additional C-C bond, or are H). (B) Alkyl vincadifformate derivs. of formula (II) are also new (the 14(15) bond is single or double; X is H or Br). (I) have antianoxic and psychotropic activity. They are useful for treating vigilance disorders (esp. due to cerebrovascular accidents and geriatric cerebral sclerosis), absences due to cranial trauma, depression, cardiocirculatory and cerebrovascular disorders. They can also be used in ophthalmology and otorhinolaryngology, esp. for treating cochleovestibular disorders. They have higher antianoxic activity than vincamine. and lower toxicity than the corresp. cpds. where R1 is Me. Daily dose is 1-300mg orally or parenterally. (II) are intermediates for (I) and also for other alkaloids.
FR7817523A 1978-06-12 1978-06-12 10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders Granted FR2428646A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR7817523A FR2428646A1 (en) 1978-06-12 1978-06-12 10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders
DE19792922316 DE2922316A1 (en) 1978-06-12 1979-05-31 NEW HALOGEN DERIVATIVES OF VINCAMINE, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
IT23464/79A IT1121787B (en) 1978-06-12 1979-06-11 HALOGENATED DERIVATIVES OF VINCAMIN, THEIR PROCEDURE OF OBTAINING AND THEIR APPLICATION AS MEDICATIONS
CH548679A CH642655A5 (en) 1978-06-12 1979-06-12 BROMINATED VINCAMINE DERIVATIVES, THEIR PROCESS FOR OBTAINING AND THEIR APPLICATION AS MEDICAMENTS.
ES481998A ES481998A0 (en) 1978-06-12 1979-06-12 PROCEDURE FOR THE PREPARATION OF HALOGENATED DERIVATIVES OF THE VINCAMINA.
GB7920355A GB2029405A (en) 1978-06-12 1979-06-12 Brominated Derivatives of Vincamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7817523A FR2428646A1 (en) 1978-06-12 1978-06-12 10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders

Publications (2)

Publication Number Publication Date
FR2428646A1 true FR2428646A1 (en) 1980-01-11
FR2428646B1 FR2428646B1 (en) 1980-11-07

Family

ID=9209378

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817523A Granted FR2428646A1 (en) 1978-06-12 1978-06-12 10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders

Country Status (1)

Country Link
FR (1) FR2428646A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463139A1 (en) * 1979-08-13 1981-02-20 Richter Gedeon Vegyeszet NOVEL HALOVINCAMONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SAME
DE3322686A1 (en) * 1982-06-30 1984-02-16 Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest NEW EBURNE DERIVATIVES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3409185A1 (en) * 1984-04-12 1985-09-26 Consiglio Nazionale Delle Ricerche, Rom/Roma Process for the preparation of eburnamonines by electrochemical means

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NV134A/68 *
NV165/68 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463139A1 (en) * 1979-08-13 1981-02-20 Richter Gedeon Vegyeszet NOVEL HALOVINCAMONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SAME
DE3322686A1 (en) * 1982-06-30 1984-02-16 Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest NEW EBURNE DERIVATIVES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3409185A1 (en) * 1984-04-12 1985-09-26 Consiglio Nazionale Delle Ricerche, Rom/Roma Process for the preparation of eburnamonines by electrochemical means

Also Published As

Publication number Publication date
FR2428646B1 (en) 1980-11-07

Similar Documents

Publication Publication Date Title
FR2383907A1 (en) PROCESS FOR PREPARING DERIVATIVES OF ACETIC ACID AND DERIVATIVES OBTAINED BY THIS PROCESS
FR2416218A1 (en) PROCESS FOR PREPARING N- (P-AMINOBENZOYL) DIALKYL GLUTAMATES
GB2210556B (en) The use of 15-keto-16-halo-prostaglandins in cathartic compositions
FR2390434A1 (en) STARTING COMPOUNDS FOR THE PREPARATION OF PENICILLANIC ACID DERIVATIVES
FR2443467A1 (en) NOVEL 3-QUINOLEINE CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENT
FR2428646A1 (en) 10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders
FR2428644A2 (en) 10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders
FR2428645A2 (en) 10-Bromo-vincamine derivs. - with anti-anoxia and psychotropic activity, used e.g. for treating cerebrovascular disorders
CH491958A (en) Process for the preparation of novel derivatives of 6-amino penicillanic acid
FR2355849A1 (en) 7 B-ACYLAMIDOCEPH-3-EME 4-CARBOXYL ACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND THERAPEUTIC APPLICATION
IE39239B1 (en) Cycloalkyl alkyl esters and process for their preparation
FR2403336A1 (en) 3,4-DIHYDROCARBOSTYRILE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE FOR THE TREATMENT OF HEART DISORDERS
FR2431496A1 (en) PROCESS FOR THE PREPARATION OF 10-BROMO-VINCAMINIC ACID ESTERS AND SIMILAR COMPOUNDS
FR1031904A (en) Process for the preparation of new derivatives of tropic acid
ES8306997A1 (en) 5 Fluoro PGI compounds.
FR2433009A1 (en) PROCESS FOR THE PREPARATION OF DICYCLOPENTYLENE (2,2'-BIS (4-ALKYL-6-T-BUTYLPHENOLS))
FR2457302A1 (en) NEW PROCESS FOR THE PURIFICATION OF URSODESOXYCHOLIC ACID
FR2429211A1 (en) PROCESS FOR THE PRODUCTION OF N-METHYLBENZOTHIAZOLONE DERIVATIVES SUBSTITUTED IN POSITION 4
FR2355839A1 (en) OPTICALLY ACTIVE DERIVATIVES OF BENZOXAZOLYL-PROPIONIC ACID, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM
FR2400508A1 (en) OXANILIC ACID DERIVATIVES, USEFUL IN PARTICULAR FOR IMPROVING AND CONTROL OF THE SYMPTOMS ASSOCIATED WITH ASTHMA, AND PREPARATION PROCESS
FR2446272A1 (en) NOVEL SUBSTITUTED PENTEN-2-YLE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE SYNTHESIS OF A CHRYSANTHEMIC ACID PRECURSOR
FR2434165A1 (en) 3a-Methyl-hexa:hydro-6-oxo-6H-indolo-(3,2,1-de) (1,5)-naphthyridine - of 3A-methyl-6-canthinone and 3-alkyl derivs. to treat depressive states, cardiovascular troubles and cerebral oxygenation insufficiency
FR2426664A1 (en) POLYHALOGENOUS HYDROCARBONS USEFUL IN PARTICULAR AS INTERMEDIATE COMPOUNDS FOR INSECTICIDES AND THEIR PRODUCTION PROCESS
FR1336143A (en) Process for the treatment of phosphoric acid obtained by the wet route to obtain phosphorus derivatives and resulting products
FR2371416A1 (en) PROCESS FOR THE PRODUCTION OF ALKYL ESTERS SUBSTITUTED WITH B-RESORCYLIC ACID

Legal Events

Date Code Title Description
ST Notification of lapse