FR2428034A2 - Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension - Google Patents

Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension

Info

Publication number
FR2428034A2
FR2428034A2 FR7817114A FR7817114A FR2428034A2 FR 2428034 A2 FR2428034 A2 FR 2428034A2 FR 7817114 A FR7817114 A FR 7817114A FR 7817114 A FR7817114 A FR 7817114A FR 2428034 A2 FR2428034 A2 FR 2428034A2
Authority
FR
France
Prior art keywords
alkyl
negligible
essential
treatment
antihypertensive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7817114A
Other languages
French (fr)
Other versions
FR2428034B2 (en
Inventor
Michael Dimsdale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7817114A priority Critical patent/FR2428034A2/en
Priority to EP78400026A priority patent/EP0000452B1/en
Priority to DE7878400026T priority patent/DE2860691D1/en
Priority to IL55104A priority patent/IL55104A/en
Priority to DK783073A priority patent/DK307378A/en
Priority to US05/922,527 priority patent/US4261994A/en
Priority to AU37909/78A priority patent/AU515506B2/en
Priority to GR56739A priority patent/GR64924B/en
Priority to NZ187825A priority patent/NZ187825A/en
Priority to NO782404A priority patent/NO782404L/en
Priority to IT25497/78A priority patent/IT1096906B/en
Priority to PT68267A priority patent/PT68267A/en
Priority to CA307,090A priority patent/CA1130806A/en
Priority to ES471609A priority patent/ES471609A1/en
Priority to JP53085017A priority patent/JPS5834473B2/en
Priority to FI782220A priority patent/FI782220A/en
Priority to AT505378A priority patent/AT362367B/en
Priority to AR272930A priority patent/AR222310A1/en
Priority to ES478527A priority patent/ES478527A1/en
Priority to US06/034,197 priority patent/US4242352A/en
Publication of FR2428034A2 publication Critical patent/FR2428034A2/en
Application granted granted Critical
Publication of FR2428034B2 publication Critical patent/FR2428034B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Abstract

Oxadiazole derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new (where R1-5 are each H, halogen, or alkyl, or 2 adjacent gps. together with the benzene nucleus may form a naphthalene system, and 2 of R1-5 are not H when R is NH2; R is -NR'R" or -N=CR'3-NR'1R'2; R' is H, dialkylaminoalkyl, hydroxyalkyl, dialkylamino-alkoxycarbonyl, pyridinoalkyl or alkyl; R" is H or alkyl; R'3 is H, alkyl, aryl or aralkyl; R'1 and R'2 are each alkyl, hydroxyalkyl or dialkylamino-alkyl; or -NR'R" or -NR'1R'2 may form a heterocycle opt contg. another heteroatom which may be substd. by alkyl; all alkyl gps. are 1-4C). (I) are antihypertensives, useful in treatment of essential or secondary hypertension, and have negligible sedative activity. Doses are e.g. 4-100 mg p.o/day.
FR7817114A 1977-07-12 1978-06-08 Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension Granted FR2428034A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR7817114A FR2428034A2 (en) 1978-06-08 1978-06-08 Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension
EP78400026A EP0000452B1 (en) 1977-07-12 1978-06-20 1,2,4-oxadiazol derivatives, their preparation and application in pharmaceutical compositions
DE7878400026T DE2860691D1 (en) 1977-07-12 1978-06-20 1,2,4-oxadiazol derivatives, their preparation and application in pharmaceutical compositions
DK783073A DK307378A (en) 1977-07-12 1978-07-07 PROCEDURE FOR THE PREPARATION OF 1,2,4-OXADIAZOLES
US05/922,527 US4261994A (en) 1977-07-12 1978-07-07 1,2,4-Oxadiazole derivatives, their preparation and pharmaceutical use
IL55104A IL55104A (en) 1977-07-12 1978-07-07 1,2,4-oxadiazole derivatives,their preparation and pharmaceutical compositions containing them
IT25497/78A IT1096906B (en) 1977-07-12 1978-07-10 1,2,4-OXADIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY
GR56739A GR64924B (en) 1977-07-12 1978-07-10 Method for the preparation of oxadiazole derivatives
NZ187825A NZ187825A (en) 1977-07-12 1978-07-10 1,2,4-oxadiazole derivatives and pharmaceutical compositions
NO782404A NO782404L (en) 1977-07-12 1978-07-10 PROCEDURE FOR THE PREPARATION OF OXADIAZOLE DERIVATIVES
AU37909/78A AU515506B2 (en) 1977-07-12 1978-07-10 1, 2, 4-oxadiazole derivatives
PT68267A PT68267A (en) 1977-07-12 1978-07-10 PROCESS FOR PREPARING OXADIAZOLE-1,2,4 DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
CA307,090A CA1130806A (en) 1977-07-12 1978-07-10 1,2,4-oxadiazole derivatives, their preparation and pharmaceutical use
ES471609A ES471609A1 (en) 1977-07-12 1978-07-11 1,2,4-Oxadiazol derivatives, their preparation and application in pharmaceutical compositions.
JP53085017A JPS5834473B2 (en) 1977-07-12 1978-07-11 1,2,4↓-oxadiazole derivative
FI782220A FI782220A (en) 1977-07-12 1978-07-11 OXADIAZOLE-1,2,4-DERIVATIVES FOR THE FRAMEWORK OF MEDICINAL PRODUCTS
AR272930A AR222310A1 (en) 1977-07-12 1978-07-12 PROCEDURE FOR PREPARING DERIVATIVES OF 5-BENCIL- (1,2,4) -OXADIAZOLE
AT505378A AT362367B (en) 1977-07-12 1978-07-12 METHOD FOR PRODUCING NEW 1,2,4-OXADIA DIAZOLE DERIVATIVES AND SALTS OF THESE COMPOUNDS
ES478527A ES478527A1 (en) 1977-07-12 1979-03-12 1,2,4-Oxadiazol derivatives, their preparation and application in pharmaceutical compositions.
US06/034,197 US4242352A (en) 1977-07-12 1979-04-27 3-Amino-5-benzyl-1,2,4-oxadiazoles and anti-hypertensive compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7817114A FR2428034A2 (en) 1978-06-08 1978-06-08 Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension

Publications (2)

Publication Number Publication Date
FR2428034A2 true FR2428034A2 (en) 1980-01-04
FR2428034B2 FR2428034B2 (en) 1980-10-10

Family

ID=9209229

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817114A Granted FR2428034A2 (en) 1977-07-12 1978-06-08 Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension

Country Status (1)

Country Link
FR (1) FR2428034A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993009106A1 (en) * 1991-10-28 1993-05-13 Tsentr Po Khimii Lekarstvennykh Sredstv Derivatives of 5-phenoxymethyl-1,2,4-oxadiazol, their salts, method of obtaining them and a pharmaceutical preparation with antihypertensive, antianginal, antiarrhythmic and antiglaucomatomic properties based on them

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2461882A1 (en) * 1973-12-29 1975-07-03 Chinoin Gyogyszer Es Vegyeszet PROCESS FOR THE PREPARATION OF 3-AMINO-1,2,4-OXADIAZOLES

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2461882A1 (en) * 1973-12-29 1975-07-03 Chinoin Gyogyszer Es Vegyeszet PROCESS FOR THE PREPARATION OF 3-AMINO-1,2,4-OXADIAZOLES

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/74 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993009106A1 (en) * 1991-10-28 1993-05-13 Tsentr Po Khimii Lekarstvennykh Sredstv Derivatives of 5-phenoxymethyl-1,2,4-oxadiazol, their salts, method of obtaining them and a pharmaceutical preparation with antihypertensive, antianginal, antiarrhythmic and antiglaucomatomic properties based on them

Also Published As

Publication number Publication date
FR2428034B2 (en) 1980-10-10

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