FR2426473A1 - Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser - Google Patents
Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiserInfo
- Publication number
- FR2426473A1 FR2426473A1 FR7815726A FR7815726A FR2426473A1 FR 2426473 A1 FR2426473 A1 FR 2426473A1 FR 7815726 A FR7815726 A FR 7815726A FR 7815726 A FR7815726 A FR 7815726A FR 2426473 A1 FR2426473 A1 FR 2426473A1
- Authority
- FR
- France
- Prior art keywords
- blood
- leukaemia
- radiation
- phenothiazine
- irradiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
Abstract
Leukaemia is treated by establishing extra-corporeal circulation of the blood contg. leukaemia tumour cells and irradiating this blood with UV rays in the presence of a phenothiazine amine (I) as radiation sensitiser. The appts. for obtaining a thin layer of the blood for irradiation is also claimed. Suitable phenothiazines (I) include methopromazine, thioproperazine, prochlorpemazine, acepromazine, levomepromazine, promethazine, alimemazine and esp. chlorpromazine. (I) is perfused into the blood at the radiation zone at a dose of about 2 mg./kg. body wt. It is usually infused slowly at 0.5 ml./min. as an aq. soln. contg. 10 mg. (I)/ml. The UV radiation is usually at 2200-5800 angstroms.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7815726A FR2426473A1 (en) | 1978-05-26 | 1978-05-26 | Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7815726A FR2426473A1 (en) | 1978-05-26 | 1978-05-26 | Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2426473A1 true FR2426473A1 (en) | 1979-12-21 |
Family
ID=9208735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7815726A Withdrawn FR2426473A1 (en) | 1978-05-26 | 1978-05-26 | Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2426473A1 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0030358A2 (en) * | 1979-12-11 | 1981-06-17 | Leukocyte Research, Inc. | Apparatus for reducing the functioning lymphocyte population in blood |
FR2507482A1 (en) * | 1981-06-12 | 1982-12-17 | Edelson Richard | METHOD AND DEVICE FOR THE EXTRACORPOREAL TREATMENT OF BLOOD |
US4428744A (en) | 1979-12-11 | 1984-01-31 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
EP0138489A1 (en) * | 1983-09-29 | 1985-04-24 | McNeilab, Inc. | Apparatus and methods for treating cells with radiation |
US4612007A (en) * | 1981-06-16 | 1986-09-16 | Edelson Richard Leslie | Method and system for externally treating the blood |
US4613322A (en) * | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
US4684521A (en) * | 1982-12-08 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
US4683889A (en) * | 1983-03-29 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
EP0240152A1 (en) * | 1986-02-27 | 1987-10-07 | McNeilab, Inc. | Irradiation chamber for photoactivation patient treatment system |
FR2607705A1 (en) * | 1986-12-08 | 1988-06-10 | Carraz Gilbert | Device for extracorporeal irradiation of blood |
WO2002096400A1 (en) * | 2001-06-01 | 2002-12-05 | Molecular Engines Laboratories | Medicament which can be used for the treatment of cancer |
WO2004080445A1 (en) * | 2003-03-12 | 2004-09-23 | Molecular Engines Laboratories Sa | Methods and compositions for the treatment of cancer |
WO2006128047A2 (en) * | 2005-05-27 | 2006-11-30 | Energex Systems, Inc. | Blood irradiation system device |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1233327A (en) * | 1959-03-26 | 1960-10-12 | Device for blood processing | |
US3325641A (en) * | 1964-02-17 | 1967-06-13 | George W Jones | Apparatus for treating a thin film of liquid by exposure to radiant energy |
-
1978
- 1978-05-26 FR FR7815726A patent/FR2426473A1/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1233327A (en) * | 1959-03-26 | 1960-10-12 | Device for blood processing | |
US3325641A (en) * | 1964-02-17 | 1967-06-13 | George W Jones | Apparatus for treating a thin film of liquid by exposure to radiant energy |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0030358A3 (en) * | 1979-12-11 | 1982-03-24 | Leukocyte Research, Inc. | Method and system for externally treating human blood |
US4428744A (en) | 1979-12-11 | 1984-01-31 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
EP0030358A2 (en) * | 1979-12-11 | 1981-06-17 | Leukocyte Research, Inc. | Apparatus for reducing the functioning lymphocyte population in blood |
FR2507482A1 (en) * | 1981-06-12 | 1982-12-17 | Edelson Richard | METHOD AND DEVICE FOR THE EXTRACORPOREAL TREATMENT OF BLOOD |
DE3222244A1 (en) * | 1981-06-12 | 1983-02-24 | Richard Leslie Roseland N.J. Edelson | METHOD AND DEVICE FOR TREATING HUMAN BLOOD |
US4612007A (en) * | 1981-06-16 | 1986-09-16 | Edelson Richard Leslie | Method and system for externally treating the blood |
US4684521A (en) * | 1982-12-08 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
US4613322A (en) * | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
US4683889A (en) * | 1983-03-29 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
EP0138489A1 (en) * | 1983-09-29 | 1985-04-24 | McNeilab, Inc. | Apparatus and methods for treating cells with radiation |
EP0240152A1 (en) * | 1986-02-27 | 1987-10-07 | McNeilab, Inc. | Irradiation chamber for photoactivation patient treatment system |
FR2607705A1 (en) * | 1986-12-08 | 1988-06-10 | Carraz Gilbert | Device for extracorporeal irradiation of blood |
WO2002096400A1 (en) * | 2001-06-01 | 2002-12-05 | Molecular Engines Laboratories | Medicament which can be used for the treatment of cancer |
FR2825279A1 (en) * | 2001-06-01 | 2002-12-06 | Molecular Engines Lab | MEDICINE USEFUL IN THE TREATMENT OF CANCER |
WO2004080445A1 (en) * | 2003-03-12 | 2004-09-23 | Molecular Engines Laboratories Sa | Methods and compositions for the treatment of cancer |
WO2006128047A2 (en) * | 2005-05-27 | 2006-11-30 | Energex Systems, Inc. | Blood irradiation system device |
WO2006128047A3 (en) * | 2005-05-27 | 2007-01-11 | Energex Systems Inc | Blood irradiation system device |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |