FR2425426A1 - PEPTIDES RELATED TO SOMATOSTATIN - Google Patents

PEPTIDES RELATED TO SOMATOSTATIN

Info

Publication number
FR2425426A1
FR2425426A1 FR7910195A FR7910195A FR2425426A1 FR 2425426 A1 FR2425426 A1 FR 2425426A1 FR 7910195 A FR7910195 A FR 7910195A FR 7910195 A FR7910195 A FR 7910195A FR 2425426 A1 FR2425426 A1 FR 2425426A1
Authority
FR
France
Prior art keywords
gly
trp
ala
somatostatin
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7910195A
Other languages
French (fr)
Other versions
FR2425426B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/019,216 external-priority patent/US4253998A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of FR2425426A1 publication Critical patent/FR2425426A1/en
Application granted granted Critical
Publication of FR2425426B1 publication Critical patent/FR2425426B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Peptides corresponding to the formula in which X represents H, -NH2, -NH-Gly-Ala, -NH-D-Ala-Ala, -NH-Gly-Gly-Gly, -NH-acetyl or -NH-benzoyl; X1 represents His or Arg; X2 represents His, Glu, Tyr, Trp or Phe; X3 represents Trp, D-Trp or 6-F-D-Trp; and X4 represents a D- alpha -amino acid, or their reduced linear forms or also their acid addition salts. These peptides can be used as medicaments.
FR7910195A 1978-04-24 1979-04-23 PEPTIDES RELATED TO SOMATOSTATIN Granted FR2425426A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89943878A 1978-04-24 1978-04-24
US06/019,216 US4253998A (en) 1979-03-09 1979-03-09 Peptides related to somatostatin

Publications (2)

Publication Number Publication Date
FR2425426A1 true FR2425426A1 (en) 1979-12-07
FR2425426B1 FR2425426B1 (en) 1983-11-10

Family

ID=26691991

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7910195A Granted FR2425426A1 (en) 1978-04-24 1979-04-23 PEPTIDES RELATED TO SOMATOSTATIN

Country Status (6)

Country Link
JP (1) JPS54145630A (en)
CH (1) CH638776A5 (en)
DE (1) DE2916536A1 (en)
FR (1) FR2425426A1 (en)
IT (1) IT1166758B (en)
NL (1) NL7902932A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK81082A (en) * 1981-03-06 1982-09-07 Sandoz Ag PROCEDURE FOR PREPARING POLYPEPTIDES

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE855473A (en) * 1976-06-07 1977-10-03 Salk Inst For Biological Studi ANALOGUES OF SOMATOSTATIN
US4077952A (en) * 1977-03-17 1978-03-07 American Home Products Corporation Somatostatin analogs
BE864209A (en) * 1977-02-22 1978-08-22 American Home Prod SOMATOSTATIN ANALOGUES AND THEIR PREPARATION

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE855473A (en) * 1976-06-07 1977-10-03 Salk Inst For Biological Studi ANALOGUES OF SOMATOSTATIN
BE864209A (en) * 1977-02-22 1978-08-22 American Home Prod SOMATOSTATIN ANALOGUES AND THEIR PREPARATION
US4077952A (en) * 1977-03-17 1978-03-07 American Home Products Corporation Somatostatin analogs

Also Published As

Publication number Publication date
CH638776A5 (en) 1983-10-14
IT7922062A0 (en) 1979-04-23
NL7902932A (en) 1979-10-26
JPS54145630A (en) 1979-11-14
FR2425426B1 (en) 1983-11-10
DE2916536A1 (en) 1979-10-31
IT1166758B (en) 1987-05-06

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Legal Events

Date Code Title Description
ST Notification of lapse