FR2421911A2 - 11,17,21-Tri:hydroxy-pregn-4-ene-3,20-di:one derivs. - useful as antiallergic agents with reduced antiinflammatory activity - Google Patents

11,17,21-Tri:hydroxy-pregn-4-ene-3,20-di:one derivs. - useful as antiallergic agents with reduced antiinflammatory activity

Info

Publication number
FR2421911A2
FR2421911A2 FR7810386A FR7810386A FR2421911A2 FR 2421911 A2 FR2421911 A2 FR 2421911A2 FR 7810386 A FR7810386 A FR 7810386A FR 7810386 A FR7810386 A FR 7810386A FR 2421911 A2 FR2421911 A2 FR 2421911A2
Authority
FR
France
Prior art keywords
derivs
useful
pregn
ene
tri
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7810386A
Other languages
French (fr)
Other versions
FR2421911B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7810386A priority Critical patent/FR2421911A2/en
Publication of FR2421911A2 publication Critical patent/FR2421911A2/en
Application granted granted Critical
Publication of FR2421911B2 publication Critical patent/FR2421911B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Pregnene derivs. of formula (I) within the scope of the parent patent are new: In (I), Z, DELTA' present, Y and R1 are respectively, (i) CH3O, NO, H and H or acetyl; (ii) CH3O, YES or NO, F and acetyl; (iii) cyclopentyloxy, NO, F and H; (iv) EtOCONH or NH2CONH, YES, F and H; and (v) PhNHCOO, NO, F and H or acetyl. All cpds. may be anti or isomers. (I) have antiallergic activity at least as good as dexamethasone but with a better dissociation between antiallergic and antiinflammatory effects. They are useful in human or veterinary medicine for treating rhinits, asthma and skin disorders such as urticaria.
FR7810386A 1978-04-07 1978-04-07 11,17,21-Tri:hydroxy-pregn-4-ene-3,20-di:one derivs. - useful as antiallergic agents with reduced antiinflammatory activity Granted FR2421911A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7810386A FR2421911A2 (en) 1978-04-07 1978-04-07 11,17,21-Tri:hydroxy-pregn-4-ene-3,20-di:one derivs. - useful as antiallergic agents with reduced antiinflammatory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7810386A FR2421911A2 (en) 1978-04-07 1978-04-07 11,17,21-Tri:hydroxy-pregn-4-ene-3,20-di:one derivs. - useful as antiallergic agents with reduced antiinflammatory activity

Publications (2)

Publication Number Publication Date
FR2421911A2 true FR2421911A2 (en) 1979-11-02
FR2421911B2 FR2421911B2 (en) 1984-06-22

Family

ID=9206848

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7810386A Granted FR2421911A2 (en) 1978-04-07 1978-04-07 11,17,21-Tri:hydroxy-pregn-4-ene-3,20-di:one derivs. - useful as antiallergic agents with reduced antiinflammatory activity

Country Status (1)

Country Link
FR (1) FR2421911A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3074979A (en) * 1961-05-08 1963-01-22 Merck & Co Inc 3-mono-oxime derivatives of c-4 unsaturated steroids
DE1568520A1 (en) * 1966-05-04 1970-07-16 Bayer Ag Process for the production of 3-imino-delta? -Steroids
FR1600937A (en) * 1967-12-08 1970-08-03

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3074979A (en) * 1961-05-08 1963-01-22 Merck & Co Inc 3-mono-oxime derivatives of c-4 unsaturated steroids
DE1568520A1 (en) * 1966-05-04 1970-07-16 Bayer Ag Process for the production of 3-imino-delta? -Steroids
FR1600937A (en) * 1967-12-08 1970-08-03

Also Published As

Publication number Publication date
FR2421911B2 (en) 1984-06-22

Similar Documents

Publication Publication Date Title
DE3779149D1 (en) GALANTHAMINE OR ITS ANALOG FOR TREATING ALZHEIMER'S DISEASE.
DE69201564D1 (en) USE OF METAL OXIDE MANOPIGMENTS FOR PROTECTING HAIR KERATIN FROM EXTERNAL INFLUENCES, IN PARTICULAR SUNLIGHT, PROCESS FOR PROTECTING THE HAIR AND GEL COMPOSITION USING THESE NANOPIGMENTS.
DE69218255D1 (en) USE OF AMINO-2-TRIFLUORMETHOXY-6-BENZOTHIAZOLE (RILUZOLE) FOR PRODUCING A MEDICINE FOR TREATING DISEASES OF THE MOTONEURON
HU174228B (en) New x-ray-contrast materials and process for producing their active agents, i.e. new dicarboxylic-bis-square bracket-3,5-bis-bracket-carbamoyl-bracket closed-2,4,6-triiodo-anilides-square bracket closed
UA43378C2 (en) Composition for treating the respiratory distress- syndrome of the newborns and respiratory distress- syndrome of the adult
ATE145136T1 (en) USE OF KETOCONAZOLE AND A RETINOID FOR THE TREATMENT OF ACNE VULGARIS
AT350158B (en) BINDERS ON THE BASIS OF Aqueous ALKALIZATE SOLUTIONS, AS WELL AS PROCESS FOR MANUFACTURING THE BINDING AGENT AND ITS USE
DE69631478D1 (en) USE OF VITAMIN D4 DERIVATIVES FOR THE TREATMENT OF SKIN DISEASES
DE68912195D1 (en) Use of pyrrolicloncarboxylic acid alkyl esters for the manufacture of a medicament for the treatment of ichthyosis.
ATE158184T1 (en) MANUFACTURING AND USE OF TRANSFER FACTOR
LU80775A1 (en) 1,2,4-OXADIAZOLE DERIVATIVES, PROCESS FOR PREPARING THESE COMPOUNDS AND THESE CONTAINING SELECTIVE HERBICIDAL AGENTS
DE69824576D1 (en) USE OF TETRAHYDROPYRIDINE DERIVATIVES FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF DEMYELINISING DISEASES
NO994330D0 (en) Method of treating a tumor
DE69233725D1 (en) Use of DNA or RNA for the manufacture of a medicament for the treatment of tumors
DE2964774D1 (en) 2,6-dialkoxybenzamides, process for their preparation, compositions and these compounds for use in the treatment of psychotic disordes
DE2961490D1 (en) Compositions for cytochemical investigation, their use and method for the detection of steroid hormone receptors in human tissues
FR2421911A2 (en) 11,17,21-Tri:hydroxy-pregn-4-ene-3,20-di:one derivs. - useful as antiallergic agents with reduced antiinflammatory activity
DE69232911D1 (en) Use of a polyhydroxybenzamide or its derivative in the manufacture of a medicament for the treatment of viral infections
ATE107656T1 (en) PROCESS FOR THE PREPARATION OF 14-ALPHA-HYDROXY-4-ANDROSENE-3,6,17, TRION.
MY102270A (en) New furanuronic acid derivatives, process their production and their use.
DE69003960D1 (en) The use of deacetylated chitin in the manufacture of a medicament for the treatment of inflammatory diseases.
ATE206052T1 (en) USE OF SPHINGOSINE-1-PHOSPHATE, SPHINGOSINE-1-PHOSPHATE DERIVATIVES AND/OR MIXTURES THEREOF FOR THE TREATMENT OF INFLAMMATORY SKIN DISEASES
DE69300127D1 (en) Use of azole derivatives for the manufacture of medicaments for the inhibition of aromatase and for the treatment of estrogen-dependent diseases.
IL55112A (en) Process for the preparation of chromone acetic acid derivatives,certain new such derivatives and their use as plant protection agents
GB2030043B (en) Injectable composition for the treatment of helminthiasis and clostridial diseases in animals