FR2414049A2 - NEW HETEROCYCLIC DERIVATIVES OF 7 H-1,3,4 - THIADIAZOLO - (3,2-A) PYRIMIDINE - 7 - ONE - 5 - CARBOXYLIC ACID, THEIR PROCESS OF PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM - Google Patents

NEW HETEROCYCLIC DERIVATIVES OF 7 H-1,3,4 - THIADIAZOLO - (3,2-A) PYRIMIDINE - 7 - ONE - 5 - CARBOXYLIC ACID, THEIR PROCESS OF PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM

Info

Publication number
FR2414049A2
FR2414049A2 FR7835058A FR7835058A FR2414049A2 FR 2414049 A2 FR2414049 A2 FR 2414049A2 FR 7835058 A FR7835058 A FR 7835058A FR 7835058 A FR7835058 A FR 7835058A FR 2414049 A2 FR2414049 A2 FR 2414049A2
Authority
FR
France
Prior art keywords
thiadiazolo
derivatives
pyrimidine
preparation
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7835058A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of FR2414049A2 publication Critical patent/FR2414049A2/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'ADDITION CONCERNE DE NOUVEAUX DERIVES A SUBSTITUANT BASIQUE EN POSITION 2 DE L'ACIDE 7H-1,3,4-THIADIAZOLO-3,2-APYRIMIDINE-7-ONE-5-CARBOXYLIQUE, LEURS ESTERS ALKYLIQUES ETOU LEURS SELS ACCEPTABLES DU POINT DE VUE PHARMACEUTIQUE, SUIVANT LE BREVET PRINCIPAL. ON OBTIENT CES DERIVES PAR REACTION DE 2-AMINO-5-(SUBSTITUANT BASIQUE)-1,3,4-THIADIAZOLES AVEC DES ESTERS D'ACIDES ACETYLENEDICARBOXYLIQUES ET SAPONIFICATION SUBSEQUENTE EVENTUELLE DU GROUPEMENT ESTER ETOU TRANSFORMATION EN SELS ACCEPTABLES DU POINT DE VUE PHARMACEUTIQUE. LES DERIVES DE L'ADDITION SONT DES SUBSTANCES NOUVELLES QUI PEUVENT ETRE UTILISEES COMME SUBSTANCES ACTIVES DANS DES MEDICAMENTS; ILS SONT DOUES D'ACTIVITE IMMUNO-STIMULANTE ET CONVIENNENT, NOTAMMENT, POUR UN TRAITEMENT ANTI-INFECTIEUX.THE ADDITION CONCERNS NEW DERIVATIVES WITH A BASIC SUBSTITUTE IN POSITION 2 OF 7H-1,3,4-THIADIAZOLO-3,2-APYRIMIDINE-7-ONE-5-CARBOXYL, THEIR ALKYL ESTERS AND OR THEIR ACCEPTABLE SALTS OF POINT FROM A PHARMACEUTICAL VIEW, ACCORDING TO THE MAIN PATENT. THESE DERIVATIVES ARE OBTAINED BY REACTION OF 2-AMINO-5- (BASIC SUBSTITUENT) -1,3,4-THIADIAZOLES WITH ACETYLENEDICARBOXYLIC ACID ESTERS AND POSSIBLE SUBSEQUENT SAPONIFICATION OF THE ESTER GROUP AND OR TRANSFORMATION IN ACCEPTABLE PHARMACEUTICAL SALTS OF POINT. DERIVATIVES OF THE ADDITION ARE NEW SUBSTANCES WHICH CAN BE USED AS ACTIVE SUBSTANCES IN MEDICINAL PRODUCTS; THEY ARE GIFT OF IMMUNO-STIMULATING ACTIVITY AND ARE SUITABLE, ESPECIALLY, FOR ANTI-INFECTIOUS TREATMENT.

FR7835058A 1977-12-14 1978-12-13 NEW HETEROCYCLIC DERIVATIVES OF 7 H-1,3,4 - THIADIAZOLO - (3,2-A) PYRIMIDINE - 7 - ONE - 5 - CARBOXYLIC ACID, THEIR PROCESS OF PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM Pending FR2414049A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772755615 DE2755615A1 (en) 1977-12-14 1977-12-14 NEW HETEROCYCLIC COMPOUNDS, MEDICINAL PRODUCTS CONTAINING THESE PRODUCTS AND METHODS OF MANUFACTURING THEM

Publications (1)

Publication Number Publication Date
FR2414049A2 true FR2414049A2 (en) 1979-08-03

Family

ID=6026061

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7835058A Pending FR2414049A2 (en) 1977-12-14 1978-12-13 NEW HETEROCYCLIC DERIVATIVES OF 7 H-1,3,4 - THIADIAZOLO - (3,2-A) PYRIMIDINE - 7 - ONE - 5 - CARBOXYLIC ACID, THEIR PROCESS OF PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM

Country Status (4)

Country Link
JP (1) JPS5492975A (en)
DE (1) DE2755615A1 (en)
FR (1) FR2414049A2 (en)
GB (1) GB2011390B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE855334A (en) * 1976-06-04 1977-10-03 Gruenenthal Chemie PHARMACEUTICAL COMPOSITION, NEW HETEROCYCLIC COMPOUNDS WHICH IT CONTAINS AND PROCESS FOR PREPARING THEM
FR2392028A1 (en) * 1976-06-04 1978-12-22 Gruenenthal Chemie NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE855334A (en) * 1976-06-04 1977-10-03 Gruenenthal Chemie PHARMACEUTICAL COMPOSITION, NEW HETEROCYCLIC COMPOUNDS WHICH IT CONTAINS AND PROCESS FOR PREPARING THEM
FR2392028A1 (en) * 1976-06-04 1978-12-22 Gruenenthal Chemie NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Also Published As

Publication number Publication date
DE2755615A1 (en) 1979-06-21
GB2011390B (en) 1982-04-21
GB2011390A (en) 1979-07-11
JPS5492975A (en) 1979-07-23

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