FR2409265A1 - 2- (4- (3-METHYL-2-THIENYL) PHENYL) PROPIONIC ACID AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION - Google Patents

2- (4- (3-METHYL-2-THIENYL) PHENYL) PROPIONIC ACID AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2409265A1
FR2409265A1 FR7832652A FR7832652A FR2409265A1 FR 2409265 A1 FR2409265 A1 FR 2409265A1 FR 7832652 A FR7832652 A FR 7832652A FR 7832652 A FR7832652 A FR 7832652A FR 2409265 A1 FR2409265 A1 FR 2409265A1
Authority
FR
France
Prior art keywords
thienyl
methyl
pharmaceutically acceptable
acceptable salts
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7832652A
Other languages
French (fr)
Other versions
FR2409265B1 (en
Inventor
Tsutomu Kodama
Masao Nakabayashi
Isao Watanabe
Hiroshi Hirano
Norio Abe
Katsufumi Tanaka
Hirotoshi Arai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of FR2409265A1 publication Critical patent/FR2409265A1/en
Application granted granted Critical
Publication of FR2409265B1 publication Critical patent/FR2409265B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

A.NOUVEL ACIDE 2-4-(3-METHYL-2-THIENYL)PHENYLPROPIONIQUE ET SES SELS PHARMACEUTIQUEMENT ACCEPTABLES. B.CET ACIDE REPOND A LA FORMULE: (CF DESSIN DANS BOPI) C.MEDICAMENT POUR LE TRAITEMENT DE L'INFLAMMATION ET DE LA DOULEUR.A. NEW 2-4- (3-METHYL-2-THIENYL) PHENYLPROPIONIC ACID AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS. B. THIS ACID MEETS THE FORMULA: (CF DRAWING IN BOPI) C. MEDICINAL PRODUCT FOR THE TREATMENT OF INFLAMMATION AND PAIN.

FR7832652A 1977-11-21 1978-11-20 2- (4- (3-METHYL-2-THIENYL) PHENYL) PROPIONIC ACID AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION Granted FR2409265A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13894377A JPS5481260A (en) 1977-11-21 1977-11-21 2-4-(3-methyl-2-thienyl)phenyl propionic acid, its nontoxic salt and antiphlogistics, analgesics, and antirheumatics containing them

Publications (2)

Publication Number Publication Date
FR2409265A1 true FR2409265A1 (en) 1979-06-15
FR2409265B1 FR2409265B1 (en) 1981-07-10

Family

ID=15233767

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7832652A Granted FR2409265A1 (en) 1977-11-21 1978-11-20 2- (4- (3-METHYL-2-THIENYL) PHENYL) PROPIONIC ACID AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Country Status (4)

Country Link
JP (1) JPS5481260A (en)
DE (1) DE2850485C3 (en)
FR (1) FR2409265A1 (en)
GB (1) GB2010254B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3049405A1 (en) * 1980-12-23 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW DERIVATIVES OF ANTIPHLOGISTICALLY EFFECTIVE CARBONIC ACIDS, THEIR PRODUCTION AND MEDICAL APPLICATION
GB2181728B (en) * 1985-10-21 1990-01-24 Indian Drugs & Pharma 4-(3-thienyl)phenylalkanoic acids and derivatives and process for their preparation
TW200827343A (en) 2006-09-11 2008-07-01 Fuji Yakuhin Co Ltd Novel phenylacetic acid derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5664M (en) * 1964-11-27 1968-01-02

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5664M (en) * 1964-11-27 1968-01-02

Also Published As

Publication number Publication date
DE2850485A1 (en) 1979-05-23
FR2409265B1 (en) 1981-07-10
GB2010254B (en) 1982-02-17
JPS563327B2 (en) 1981-01-24
GB2010254A (en) 1979-06-27
DE2850485B2 (en) 1981-01-08
DE2850485C3 (en) 1981-12-03
JPS5481260A (en) 1979-06-28

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Legal Events

Date Code Title Description
ST Notification of lapse