FR2398057A1 - HALOGENOMETHYL DERIVATIVES OF TRYPTOPHAN, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF DISORDERS OF THE NERVOUS SYSTEM - Google Patents

HALOGENOMETHYL DERIVATIVES OF TRYPTOPHAN, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF DISORDERS OF THE NERVOUS SYSTEM

Info

Publication number
FR2398057A1
FR2398057A1 FR7821553A FR7821553A FR2398057A1 FR 2398057 A1 FR2398057 A1 FR 2398057A1 FR 7821553 A FR7821553 A FR 7821553A FR 7821553 A FR7821553 A FR 7821553A FR 2398057 A1 FR2398057 A1 FR 2398057A1
Authority
FR
France
Prior art keywords
tryptophan
disorders
preparation
treatment
nervous system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7821553A
Other languages
French (fr)
Other versions
FR2398057B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrell Toraude et Cie
Original Assignee
Merrell Toraude et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie
Publication of FR2398057A1 publication Critical patent/FR2398057A1/en
Application granted granted Critical
Publication of FR2398057B1 publication Critical patent/FR2398057B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ces composés répondent à la formule :These compounds correspond to the formula:

FR7821553A 1977-07-21 1978-07-20 HALOGENOMETHYL DERIVATIVES OF TRYPTOPHAN, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF DISORDERS OF THE NERVOUS SYSTEM Granted FR2398057A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81759377A 1977-07-21 1977-07-21

Publications (2)

Publication Number Publication Date
FR2398057A1 true FR2398057A1 (en) 1979-02-16
FR2398057B1 FR2398057B1 (en) 1981-07-31

Family

ID=25223426

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7821553A Granted FR2398057A1 (en) 1977-07-21 1978-07-20 HALOGENOMETHYL DERIVATIVES OF TRYPTOPHAN, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF DISORDERS OF THE NERVOUS SYSTEM

Country Status (7)

Country Link
AU (1) AU518251B2 (en)
BE (1) BE869177A (en)
FR (1) FR2398057A1 (en)
GB (1) GB2001309B (en)
IT (1) IT1106106B (en)
NZ (1) NZ187545A (en)
ZA (1) ZA783356B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2499072A1 (en) * 1981-02-04 1982-08-06 Stago Laboratoire 5-ACETYLOXY-L-TRYPTOPHAN AND ITS ADDITIONAL SALTS, PREPARATION METHOD AND THERAPEUTIC USE

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491590A (en) * 1982-02-18 1985-01-01 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
DE3043252C2 (en) * 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclic acetals of N-acylglutamic acid - γ - semialdehydes, processes for their preparation and their use
FR2546517B1 (en) * 1983-05-24 1987-04-24 Panmedica NOVEL -L-5-HYDROXY-TRYPTOPHANE DIPEPTIDES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM
ZA200704925B (en) * 2004-12-22 2009-11-25 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
DK2399893T3 (en) * 2004-12-22 2018-10-08 Ambrx Inc COMPOSITIONS CONTAINING, INVOLVING PROCEDURES, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
CN113072456B (en) * 2021-04-12 2022-04-19 中国科学技术大学 Chiral alpha-difluoromethyl amino acid compound and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2499072A1 (en) * 1981-02-04 1982-08-06 Stago Laboratoire 5-ACETYLOXY-L-TRYPTOPHAN AND ITS ADDITIONAL SALTS, PREPARATION METHOD AND THERAPEUTIC USE
EP0058111A1 (en) * 1981-02-04 1982-08-18 Laboratoires Merck-Clévenot 5-Acetyloxy-L-tryptophane and its salts, process for their preparation and their therapeutical uses

Also Published As

Publication number Publication date
IT7850355A0 (en) 1978-07-18
AU518251B2 (en) 1981-09-24
BE869177A (en) 1978-11-16
IT1106106B (en) 1985-11-11
ZA783356B (en) 1979-06-27
FR2398057B1 (en) 1981-07-31
GB2001309A (en) 1979-01-31
GB2001309B (en) 1982-03-03
AU3731378A (en) 1980-01-03
NZ187545A (en) 1982-06-29

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Legal Events

Date Code Title Description
ST Notification of lapse