FR2396008A2 - Antiarrhythmic dimethoxy-benzofurans - with (5)-carbamylamino-(6)-aminoalkoxy substits. - Google Patents

Antiarrhythmic dimethoxy-benzofurans - with (5)-carbamylamino-(6)-aminoalkoxy substits.

Info

Publication number
FR2396008A2
FR2396008A2 FR7719658A FR7719658A FR2396008A2 FR 2396008 A2 FR2396008 A2 FR 2396008A2 FR 7719658 A FR7719658 A FR 7719658A FR 7719658 A FR7719658 A FR 7719658A FR 2396008 A2 FR2396008 A2 FR 2396008A2
Authority
FR
France
Prior art keywords
benzofurans
dimethoxy
antiarrhythmic
carbamylamino
substits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7719658A
Other languages
French (fr)
Other versions
FR2396008B2 (en
Inventor
Guy Bourgery
Alain Lacour
Bernard Pourrias
Genevieve Bregeon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7719658A priority Critical patent/FR2396008A2/en
Priority to CH814377A priority patent/CH625234A5/fr
Priority to GR53872A priority patent/GR61634B/en
Priority to IT7725343A priority patent/IT1115363B/en
Priority to GB28132/77A priority patent/GB1545725A/en
Priority to DE19772730593 priority patent/DE2730593A1/en
Priority to US05/813,357 priority patent/US4113951A/en
Priority to MX10080677U priority patent/MX5083E/en
Priority to MX1025877U priority patent/MX7132E/en
Priority to LU77713A priority patent/LU77713A1/xx
Priority to JP52081902A priority patent/JPS6028831B2/en
Priority to ES460600A priority patent/ES460600A1/en
Priority to SE7708041A priority patent/SE441268B/en
Priority to NL7707713A priority patent/NL7707713A/en
Priority to SU772501204A priority patent/SU655312A3/en
Priority to AU26954/77A priority patent/AU516331B2/en
Priority to CA282,550A priority patent/CA1100958A/en
Priority to US05/914,872 priority patent/US4153620A/en
Priority to ES470784A priority patent/ES470784A1/en
Priority to ES470783A priority patent/ES470783A1/en
Priority to SU782700463A priority patent/SU747425A3/en
Priority to SU782700462A priority patent/SU778710A3/en
Publication of FR2396008A2 publication Critical patent/FR2396008A2/en
Application granted granted Critical
Publication of FR2396008B2 publication Critical patent/FR2396008B2/fr
Priority to CH851780A priority patent/CH627175A5/fr
Priority to CH851680A priority patent/CH630621A5/en
Priority to SE8300445A priority patent/SE8300445L/en
Priority to SE8300446A priority patent/SE8300446L/en
Priority to JP5880983A priority patent/JPS58213770A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Benzofurans of formula (I) are new where the 3 values R5, m, and -NR3R4 are H, 1, and 1-2C N-alkylamino when -NR1R2 is mono-(1-3C alkyl)-amino, di-(1-3C alkyl)-amino, 5-6C cycloalkylamino, or a heterocyclic gp.; and the 3 values are H, 2, and -NHMe, H, 1, and 4-methylpiperazino, Me, 1 and -NHMe or H, 1 and -NMe2 when -NR1R2 is piperidino . Cpds. (I) are antiarrhythmic agents for treating tachycardia etc. A typical cpd., 4,7-dimethoxy-6-(2isopropylaminoethoxy)-5-(N-methylcarbamoyl)amin- obenzofuran, was prepd. by a 3-stage process from 5-amino-4,7-di-methoxy-6-hydroxybenzofuran.
FR7719658A 1976-07-12 1977-06-27 Antiarrhythmic dimethoxy-benzofurans - with (5)-carbamylamino-(6)-aminoalkoxy substits. Granted FR2396008A2 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR7719658A FR2396008A2 (en) 1977-06-27 1977-06-27 Antiarrhythmic dimethoxy-benzofurans - with (5)-carbamylamino-(6)-aminoalkoxy substits.
CH814377A CH625234A5 (en) 1976-07-12 1977-07-01
IT7725343A IT1115363B (en) 1976-07-12 1977-07-04 AMINOALCOSSIBENZOFURANI, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION IN THERAPY
GR53872A GR61634B (en) 1976-07-12 1977-07-04 Preparation process of novel aminoalcoxy-benzofurans
GB28132/77A GB1545725A (en) 1976-07-12 1977-07-05 Aminoalkoxybenzofurans their method of preparation and their application in therapeutics
DE19772730593 DE2730593A1 (en) 1976-07-12 1977-07-06 NEW AMINO-ALCOXYBENZOFURANS, METHOD FOR MANUFACTURING THE SAME PHARMACEUTICAL PRODUCTS THEREOF
US05/813,357 US4113951A (en) 1976-07-12 1977-07-06 Aminoalkoxybenzofurans
MX10080677U MX5083E (en) 1976-07-12 1977-07-07 PROCEDURE FOR THE PREPARATION OF AMINOALCOXI BENZO FURANOS
MX1025877U MX7132E (en) 1976-07-12 1977-07-07 PROCEDURE TO PREPARE AMINOALCOXIBENZOFURANOS
LU77713A LU77713A1 (en) 1976-07-12 1977-07-08
JP52081902A JPS6028831B2 (en) 1976-07-12 1977-07-08 New aminoalkoxybenzofurans and their production method
ES460600A ES460600A1 (en) 1976-07-12 1977-07-09 Aminoalkoxybenzofurans
NL7707713A NL7707713A (en) 1976-07-12 1977-07-11 PROCESS FOR THE PREPARATION OF NEW AMINO-ALKO-XYBENZOFURAN COMPOUNDS, AND THEIR USE IN MEDICINAL PRODUCTS.
SE7708041A SE441268B (en) 1976-07-12 1977-07-11 SET TO MAKE AMINOAL COXIBENZOFURANES
SU772501204A SU655312A3 (en) 1976-07-12 1977-07-12 Method of obtaining derivatives of aminoalkoxybenzofurans
AU26954/77A AU516331B2 (en) 1976-07-12 1977-07-12 Amino alkoxy benzofurans
CA282,550A CA1100958A (en) 1976-07-12 1977-07-12 No translation available
US05/914,872 US4153620A (en) 1976-07-12 1978-06-12 Certain N-5-[4,7-dimethoxy)-6-(monoalkylaminoethoxy, monocycloalkylaminoethoxy, or dialkylaminoethoxy) benzofuranyl], N'-methyl or ethyl ureas
ES470784A ES470784A1 (en) 1976-07-12 1978-06-14 Aminoalkoxybenzofurans
ES470783A ES470783A1 (en) 1976-07-12 1978-06-14 Aminoalkoxybenzofurans
SU782700463A SU747425A3 (en) 1976-07-12 1978-12-25 Method of producing derivatives of aminoalkoxybenzofuranes
SU782700462A SU778710A3 (en) 1976-07-12 1978-12-25 Method of preparing aminoalkoxybenzofuran derivatives
CH851780A CH627175A5 (en) 1976-07-12 1980-11-17
CH851680A CH630621A5 (en) 1976-07-12 1980-11-17 PROCESS FOR THE PREPARATION OF NEW AMINOALCOXYBENZOFURANS.
SE8300446A SE8300446L (en) 1976-07-12 1983-01-28 WANT TO MAKE NEW AMINOAL COXIBENOFURANES
SE8300445A SE8300445L (en) 1976-07-12 1983-01-28 WANT TO MAKE NEW AMINOAL COXYBEN OFURANES
JP5880983A JPS58213770A (en) 1976-07-12 1983-04-05 Novel 4,7-dimethoxybenzofuran derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7719658A FR2396008A2 (en) 1977-06-27 1977-06-27 Antiarrhythmic dimethoxy-benzofurans - with (5)-carbamylamino-(6)-aminoalkoxy substits.

Publications (2)

Publication Number Publication Date
FR2396008A2 true FR2396008A2 (en) 1979-01-26
FR2396008B2 FR2396008B2 (en) 1980-04-04

Family

ID=9192624

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7719658A Granted FR2396008A2 (en) 1976-07-12 1977-06-27 Antiarrhythmic dimethoxy-benzofurans - with (5)-carbamylamino-(6)-aminoalkoxy substits.

Country Status (2)

Country Link
JP (1) JPS58213770A (en)
FR (1) FR2396008A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6747098A (en) * 1997-04-11 1998-11-11 Otsuka Chemical Co. Ltd. Benzene derivatives, benzofuran derivatives, and processes for producing these

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2142648A1 (en) * 1971-06-22 1973-02-02 Delalande Sa 4,7-dimethoxy benzofurant derivs - diuretics vasodilators hypotensives spasmolytics bradycardiants and antiulcer agents
FR2178815A1 (en) * 1972-04-07 1973-11-16 Delalande Sa Furo-benzoxazole derivs - analgesics, vasodilators, diuretics, etc

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2142648A1 (en) * 1971-06-22 1973-02-02 Delalande Sa 4,7-dimethoxy benzofurant derivs - diuretics vasodilators hypotensives spasmolytics bradycardiants and antiulcer agents
FR2178815A1 (en) * 1972-04-07 1973-11-16 Delalande Sa Furo-benzoxazole derivs - analgesics, vasodilators, diuretics, etc

Also Published As

Publication number Publication date
FR2396008B2 (en) 1980-04-04
JPS616070B2 (en) 1986-02-24
JPS58213770A (en) 1983-12-12

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