FR2388829A1 - NEW ESTERS OF 6-CHLORO-11B, 17A, 21-TRIHYDROXY-PREGNA-1,4,6-TRIENE-3, 20-DIONE, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM - Google Patents

NEW ESTERS OF 6-CHLORO-11B, 17A, 21-TRIHYDROXY-PREGNA-1,4,6-TRIENE-3, 20-DIONE, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Info

Publication number
FR2388829A1
FR2388829A1 FR7812503A FR7812503A FR2388829A1 FR 2388829 A1 FR2388829 A1 FR 2388829A1 FR 7812503 A FR7812503 A FR 7812503A FR 7812503 A FR7812503 A FR 7812503A FR 2388829 A1 FR2388829 A1 FR 2388829A1
Authority
FR
France
Prior art keywords
triene
trihydroxy
dione
chloro
pregna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7812503A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of FR2388829A1 publication Critical patent/FR2388829A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne de nouveaux esters de 6-chloro-11 beta , 17 alpha , 21-trihydroxy-prégna-1,4,6-triène-3,20-dione, à savoir le 17-butyrate, le 17-benzoate, le 17,2l-méthyl-ortho-butyrate, le 17,21 méthyl-ortho-benzoate et le 17,21-dibutyrate. Elle concerne également un procède de préparation de ces nouveaux esters. Les nouveaux composés de l'invention sont des stéroïdes anti-inflammatoires à usage topique.The invention relates to novel esters of 6-chloro-11 beta, 17 alpha, 21-trihydroxy-prégna-1,4,6-triene-3,20-dione, namely 17-butyrate, 17-benzoate, 17.21-methyl-ortho-butyrate, 17.21 methyl-ortho-benzoate and 17.21-dibutyrate. It also relates to a process for preparing these new esters. The new compounds of the invention are anti-inflammatory steroids for topical use.

FR7812503A 1977-04-28 1978-04-27 NEW ESTERS OF 6-CHLORO-11B, 17A, 21-TRIHYDROXY-PREGNA-1,4,6-TRIENE-3, 20-DIONE, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM Withdrawn FR2388829A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79191177A 1977-04-28 1977-04-28

Publications (1)

Publication Number Publication Date
FR2388829A1 true FR2388829A1 (en) 1978-11-24

Family

ID=25155190

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7812503A Withdrawn FR2388829A1 (en) 1977-04-28 1978-04-27 NEW ESTERS OF 6-CHLORO-11B, 17A, 21-TRIHYDROXY-PREGNA-1,4,6-TRIENE-3, 20-DIONE, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Country Status (6)

Country Link
JP (1) JPS53135963A (en)
DE (1) DE2818319A1 (en)
ES (1) ES469237A1 (en)
FR (1) FR2388829A1 (en)
GB (1) GB1587033A (en)
IT (1) IT7867960A0 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232965A (en) * 1958-06-20 1966-02-01 Syntex Corp 6-chloro-delta1,4,6-pregnatriene-17alpha, 21-diol-3,20-diones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232965A (en) * 1958-06-20 1966-02-01 Syntex Corp 6-chloro-delta1,4,6-pregnatriene-17alpha, 21-diol-3,20-diones

Also Published As

Publication number Publication date
DE2818319A1 (en) 1978-11-02
IT7867960A0 (en) 1978-04-27
JPS53135963A (en) 1978-11-28
ES469237A1 (en) 1979-09-16
GB1587033A (en) 1981-03-25

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