FR2380781A1 - Pharmaceuticals contg. 11,17-di:hydroxy 17-alkynyl steroid(s) - with antiinflammatory activity - Google Patents

Pharmaceuticals contg. 11,17-di:hydroxy 17-alkynyl steroid(s) - with antiinflammatory activity

Info

Publication number
FR2380781A1
FR2380781A1 FR7705066A FR7705066A FR2380781A1 FR 2380781 A1 FR2380781 A1 FR 2380781A1 FR 7705066 A FR7705066 A FR 7705066A FR 7705066 A FR7705066 A FR 7705066A FR 2380781 A1 FR2380781 A1 FR 2380781A1
Authority
FR
France
Prior art keywords
contg
hydroxy
alkynyl
steroid
pharmaceuticals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7705066A
Other languages
French (fr)
Other versions
FR2380781B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7705066A priority Critical patent/FR2380781A1/en
Priority to SE7801152A priority patent/SE7801152L/en
Priority to ZA00780849A priority patent/ZA78849B/en
Priority to JP1666678A priority patent/JPS53103462A/en
Priority to US05/878,907 priority patent/US4168306A/en
Priority to IL54070A priority patent/IL54070A0/en
Priority to OA56411A priority patent/OA05890A/en
Priority to AT121078A priority patent/AT357280B/en
Priority to GR55501A priority patent/GR71701B/el
Priority to NL7801919A priority patent/NL7801919A/en
Priority to HU78RO964A priority patent/HU175028B/en
Priority to BE185352A priority patent/BE864170A/en
Priority to PT67685A priority patent/PT67685B/en
Priority to ES78467158A priority patent/ES467158A1/en
Priority to CA297,372A priority patent/CA1114366A/en
Priority to LU79100A priority patent/LU79100A1/en
Priority to DK075778A priority patent/DK160559C/en
Priority to AU33468/78A priority patent/AU514875B2/en
Priority to IE386/78A priority patent/IE46562B1/en
Priority to DE19782807611 priority patent/DE2807611A1/en
Priority to GB6984/78A priority patent/GB1598023A/en
Priority to CH193178A priority patent/CH633714A5/en
Priority to PH20808A priority patent/PH13909A/en
Publication of FR2380781A1 publication Critical patent/FR2380781A1/en
Application granted granted Critical
Publication of FR2380781B1 publication Critical patent/FR2380781B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Pharmaceutical compsns. contg. 17 alpha-alkynyl steroids of formula (I) are claimed: (where R is opt. unsatd. 1-12C alkyl; R1 and R2 are H or R1+ R2 is a bond). Also claimed are new cpds. of formula (I) where R, R1 and R2 are as above except that R is not Me when R1=R2=H. Cpds. (I) are anti-inflammatory agents with higher local activity and a higher ratio of local to systemic activity than hydrocortisone. A typical cpd. is 11 beta, 17 beta-dihydroxy-21-ethyl-pregn-4-en-20-yn-3-one. In an example, this is prepd. fro 3-ethoxy-11 beta-hydroxy-androsta-3,5-dien-17-one.
FR7705066A 1977-02-22 1977-02-22 Pharmaceuticals contg. 11,17-di:hydroxy 17-alkynyl steroid(s) - with antiinflammatory activity Granted FR2380781A1 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR7705066A FR2380781A1 (en) 1977-02-22 1977-02-22 Pharmaceuticals contg. 11,17-di:hydroxy 17-alkynyl steroid(s) - with antiinflammatory activity
SE7801152A SE7801152L (en) 1977-02-22 1978-01-31 METHOD OF PREPARING 17ALFA-ACETYLENE DERIVATIVES OF ANDROST-4-EN
ZA00780849A ZA78849B (en) 1977-02-22 1978-02-13 17a-acetylene derivatives of androst-4-ene,process for preparing them and pharmaceutical compositions
JP1666678A JPS53103462A (en) 1977-02-22 1978-02-17 11androstaa44enee17alphaaacetylene derivative process for preparing same and pharmaceutical composition
US05/878,907 US4168306A (en) 1977-02-22 1978-02-17 17α-Acetylenic-Δ4 -androstenes
IL54070A IL54070A0 (en) 1977-02-22 1978-02-17 17 -acetylene derivatives of androst-4-ene, process for preparing them and pharmaceutical compositions
OA56411A OA05890A (en) 1977-02-22 1978-02-17 Process for the preparation of 17α-acetylenic derivatives of androst 4-ene.
GR55501A GR71701B (en) 1977-02-22 1978-02-20
AT121078A AT357280B (en) 1977-02-22 1978-02-20 METHOD FOR THE PRODUCTION OF 17ALPHA- -ALKINYL-ANDROST-4-ENDERIVATEN
ES78467158A ES467158A1 (en) 1977-02-22 1978-02-21 17{60 -Acetylenic-{66 {hu 4{b -androstenes
BE185352A BE864170A (en) 1977-02-22 1978-02-21 17ALPHA-ACETYLENIC DERIVATIVES OF ANDROST 4-ENE, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS
PT67685A PT67685B (en) 1977-02-22 1978-02-21 PROCESS FOR THE PREPARATION OF 17ALPHA-ACETYLENIC DERIVATIVES OFANDROST-4-ENE
NL7801919A NL7801919A (en) 1977-02-22 1978-02-21 17- (ALPHA) -ACETYLENE DERIVATIVES OF ANDROST-U-ONE, METHOD FOR PREPARING THESE COMPOUNDS AND CORE USE IN PHARMACEUTICAL PREPARATIONS.
CA297,372A CA1114366A (en) 1977-02-22 1978-02-21 PROCESS FOR THE PREPARATION OF 17.alpha.-ACETYLENIC DERIVATIVES OF ANDROST-4-ENE
LU79100A LU79100A1 (en) 1977-02-22 1978-02-21 PROCESS FOR PREPARING 17ALPHA-ACETYLENIC DERIVATIVES OF ANDROST 4-ENE
DK075778A DK160559C (en) 1977-02-22 1978-02-21 ANALOGY PROCEDURE FOR PREPARING 17ALPFA ACETYLENE DERIVATIVES OF ANDROSTEN COMPOUNDS
AU33468/78A AU514875B2 (en) 1977-02-22 1978-02-21 17-acetylene derivatives of androst-4-ene
HU78RO964A HU175028B (en) 1977-02-22 1978-02-21 Process for producing 17-alpha-alkinyl-androst-4-ene derivatives
IE386/78A IE46562B1 (en) 1977-02-22 1978-02-22 17a-acetylene derivatives of androst-4-ene,processes for preparing them and pharmaceutical compositions containing them
DE19782807611 DE2807611A1 (en) 1977-02-22 1978-02-22 17ALPHA-ACETYLENIC DERIVATIVES OF ANDROST-4-ENE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
GB6984/78A GB1598023A (en) 1977-02-22 1978-02-22 17-acetylene derivatives of androst-4-ene processes for preparing them and pharmaceutical compositions containing them
CH193178A CH633714A5 (en) 1977-02-22 1978-02-22 17ALPHA-ACETYLENIC DERIVATIVES OF ANDROST 4-ENE, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS.
PH20808A PH13909A (en) 1977-02-22 1978-02-22 17(-acetylenic-androstenes,the pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7705066A FR2380781A1 (en) 1977-02-22 1977-02-22 Pharmaceuticals contg. 11,17-di:hydroxy 17-alkynyl steroid(s) - with antiinflammatory activity

Publications (2)

Publication Number Publication Date
FR2380781A1 true FR2380781A1 (en) 1978-09-15
FR2380781B1 FR2380781B1 (en) 1980-11-28

Family

ID=9187053

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7705066A Granted FR2380781A1 (en) 1977-02-22 1977-02-22 Pharmaceuticals contg. 11,17-di:hydroxy 17-alkynyl steroid(s) - with antiinflammatory activity

Country Status (3)

Country Link
BE (1) BE864170A (en)
FR (1) FR2380781A1 (en)
ZA (1) ZA78849B (en)

Also Published As

Publication number Publication date
ZA78849B (en) 1979-03-28
BE864170A (en) 1978-08-21
FR2380781B1 (en) 1980-11-28

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