FR2380273A1 - Imino-methyl-phenoxy-propionic acid derivs. - useful as hypocholesterolaemics, hypolipidaemics and uricosurics - Google Patents

Imino-methyl-phenoxy-propionic acid derivs. - useful as hypocholesterolaemics, hypolipidaemics and uricosurics

Info

Publication number
FR2380273A1
FR2380273A1 FR7704110A FR7704110A FR2380273A1 FR 2380273 A1 FR2380273 A1 FR 2380273A1 FR 7704110 A FR7704110 A FR 7704110A FR 7704110 A FR7704110 A FR 7704110A FR 2380273 A1 FR2380273 A1 FR 2380273A1
Authority
FR
France
Prior art keywords
phenoxy
useful
hypocholesterolaemics
hypolipidaemics
uricosurics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7704110A
Other languages
French (fr)
Other versions
FR2380273B1 (en
Inventor
Jacqueline Laforest
Jacqueline Bonnet
Pierre Bessin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Albert Rolland SA
Original Assignee
Laboratoires Albert Rolland SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Albert Rolland SA filed Critical Laboratoires Albert Rolland SA
Priority to FR7704110A priority Critical patent/FR2380273A1/en
Priority to FR7738633A priority patent/FR2412540A2/en
Priority to ZA00780608A priority patent/ZA78608B/en
Priority to IL53954A priority patent/IL53954A/en
Priority to BE184818A priority patent/BE863550A/en
Priority to IE218/78A priority patent/IE46387B1/en
Priority to US05/874,479 priority patent/US4259509A/en
Priority to LU78978A priority patent/LU78978A1/en
Priority to BG038578A priority patent/BG29874A3/en
Priority to DE19782804981 priority patent/DE2804981A1/en
Priority to FI780423A priority patent/FI780423A/en
Priority to GR55399A priority patent/GR66170B/el
Priority to AU33165/78A priority patent/AU514509B2/en
Priority to AT0095478A priority patent/AT365585B/en
Priority to JP1530078A priority patent/JPS53103466A/en
Priority to PT67649A priority patent/PT67649B/en
Priority to OA56408A priority patent/OA05887A/en
Priority to DK64678A priority patent/DK64678A/en
Priority to PL1978204590A priority patent/PL107875B1/en
Priority to NZ186459A priority patent/NZ186459A/en
Priority to CA296,950A priority patent/CA1109885A/en
Priority to HU78RO962A priority patent/HU174630B/en
Priority to NO780494A priority patent/NO780494L/en
Priority to NL7801610A priority patent/NL7801610A/en
Priority to SE7801646A priority patent/SE7801646L/en
Priority to DD78203681A priority patent/DD134094A5/en
Priority to ES467316A priority patent/ES467316A1/en
Priority to GB5847/78A priority patent/GB1551696A/en
Priority to PH20783A priority patent/PH14928A/en
Publication of FR2380273A1 publication Critical patent/FR2380273A1/en
Priority to AR275772A priority patent/AR215998A1/en
Application granted granted Critical
Publication of FR2380273B1 publication Critical patent/FR2380273B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Phenoxypropionic acid derivs. of formula (I), their salts with bases and cpds. converted to (I) in vivo, are new: In (I), A is O or S. X1 is halo, H or CH3. R is H or 1-5C alkyl. X2 and X3 are H, halo or 1-5C akyl. R1 is H or 1-5C alkyl. -C(NOR)-is at the 2 or 3 posn. of the heterocycle and the cpd. is in the E and/or Z isomeric forms. (I) have hypocholesterolaemic, hypolipidaemic and uricosuric activities and are useful for treating or preventing cardiovascular disorders and gout. They have a better therapeutic index than the corresp. ketones and their LD50 is higher, generally >1 g./kg. orally in mice. In an example, ethyl 2- 2-bromo-4-(2-thienylhydroxy-iminomethyl)-phenoxy -2-methylprop- ionate was prepd. from the corresp. 4-(2-thenoyl)cpd. and NH2OH hydrochloride.
FR7704110A 1977-02-14 1977-02-14 Imino-methyl-phenoxy-propionic acid derivs. - useful as hypocholesterolaemics, hypolipidaemics and uricosurics Granted FR2380273A1 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
FR7704110A FR2380273A1 (en) 1977-02-14 1977-02-14 Imino-methyl-phenoxy-propionic acid derivs. - useful as hypocholesterolaemics, hypolipidaemics and uricosurics
FR7738633A FR2412540A2 (en) 1977-02-14 1977-12-21 NEW PROCESS FOR THE PREPARATION OF DERIVATIVES OF METHYL-2 PHENOXY-2 PROPIONIC ACID, NEW DERIVATIVES OF METHYL-2 PHENOXY-2 PROPIONIC ACID AND THEIR APPLICATION IN THERAPEUTICS
IL53954A IL53954A (en) 1977-02-14 1978-02-01 Thienyl(furyl)hydroximino methyl phenoxy propionic acid derivatives,their preparation and pharmaceutical compositions containing them
BE184818A BE863550A (en) 1977-02-14 1978-02-01 DERIVATIVES OF METHYL-2 PHENOXY-2 PROPIONIC ACIDS, THEIR PROCESS OF PREPARATION AND THEIR APPLICATIONS IN THERAPEUTICS
ZA00780608A ZA78608B (en) 1977-02-14 1978-02-01 2-methyl-2-phenoxy-propionic acid derivatives,process for their preparation and therapeutical applications thereof
IE218/78A IE46387B1 (en) 1977-02-14 1978-02-02 Oximes of (thenoyl- or furoyl-phenoxy)-2-methyl-2-propionic acids
US05/874,479 US4259509A (en) 1977-02-14 1978-02-02 2-Methyl-2-phenoxy-propionic acid derivatives, process for their preparation and therapeutical applications thereof
LU78978A LU78978A1 (en) 1977-02-14 1978-02-02 PROCESS FOR PREPARATION OF DERIVATIVES OF METHYL-2PHENOXY-2 PROPIONIC ACIDS
BG038578A BG29874A3 (en) 1977-02-14 1978-02-03 METHOD FOR OBTAINING DERIVATIVES OF METHYL-2-PHENOXY-2-PROPIONIC ACIDS
DE19782804981 DE2804981A1 (en) 1977-02-14 1978-02-06 DERIVATIVES OF 2-METHYL-2-PHENOXY-PROPIONIC ACIDS, THE METHOD FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE
FI780423A FI780423A (en) 1977-02-14 1978-02-09 FRAME STATION FOR 2-METHYL-2-PHENOXIPROPIONSYRADERIVAT
GR55399A GR66170B (en) 1977-02-14 1978-02-09
AU33165/78A AU514509B2 (en) 1977-02-14 1978-02-09 2-methyl-2-phonoxy=propionic acid derivatives
AT0095478A AT365585B (en) 1977-02-14 1978-02-10 METHOD FOR THE PRODUCTION OF NEW 2-METHYL-2PHENOXYPROPIONIC ACID DERIVATIVES AND THEIR PHYSIOLOGICALLY COMPATIBLE SALTS
JP1530078A JPS53103466A (en) 1977-02-14 1978-02-13 22methyll22phenoxyypropionate derivative process for preparing same and medical compostion containing same
OA56408A OA05887A (en) 1977-02-14 1978-02-13 Derivatives of 2-methyl-2-phenoxypropionic acids, their preparation process and their applications in therapy.
DK64678A DK64678A (en) 1977-02-14 1978-02-13 PROCEDURE FOR PREPARING 2-METHYL-2-PHENOXYPROPIONIC ACID DERIVATIVES
PL1978204590A PL107875B1 (en) 1977-02-14 1978-02-13 METHOD OF PRODUCING NEW DERIVATIVES OF 2-METHYLMETHOD OF PRODUCING NEW DERIVATIVES OF 2-METHYL-2-PHENOXYPROPIONIC ACID O-2-PHENOXYPROPIONIC ACID
NZ186459A NZ186459A (en) 1977-02-14 1978-02-13 Oximes of 2-methyl-2-(thienoyl-or furoylphenoxy-) propiontc acids and pharmaceutical compositions
CA296,950A CA1109885A (en) 1977-02-14 1978-02-13 Process for the preparation of 2-methyl-2-phenoxy- propionic acid derivatives
HU78RO962A HU174630B (en) 1977-02-14 1978-02-13 Process for producing 2-methyl-2-bracket-thenoil- or furoil-phenoxy-bracket closed-propionic-acid-oximes
NO780494A NO780494L (en) 1977-02-14 1978-02-13 METHYL-2 PRODUCT PROCEDURES FENOXY-2 PROPION ACID DERIVATIVES
PT67649A PT67649B (en) 1977-02-14 1978-02-13 PROCESS FOR PREPARING METHYL-2-PHENOXY-2-PROPIONIC ACID DERIVATIVES
SE7801646A SE7801646L (en) 1977-02-14 1978-02-13 WAY TO PREPARE THERAPEUTICALLY VALUABLE NEW 2-METHYL-2-PHENOXI-PROPIONIC ACID DERIVATIVES
DD78203681A DD134094A5 (en) 1977-02-14 1978-02-13 PROCESS FOR PREPARING DERIVATIVES OF 2-METHYL-2-PHENOXY PROPIONE ACIDS
NL7801610A NL7801610A (en) 1977-02-14 1978-02-13 2-METHYL 2-PHENOXYPROPION ACID DERIVATIVES, METHOD FOR PREPARING THEM, AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS.
ES467316A ES467316A1 (en) 1977-02-14 1978-02-14 2-Methyl-2-phenoxy-propionic acid derivatives, process for their preparation and therapeutical applications thereof
GB5847/78A GB1551696A (en) 1977-02-14 1978-02-14 Oximes of (thenoyl- or furoyl-phenoxy)-2-methyl-2-propionic
PH20783A PH14928A (en) 1977-02-14 1978-02-14 2-methyl-2-phenoxy-propionic acid derivatives
AR275772A AR215998A1 (en) 1977-02-14 1979-03-12 PROCEDURE FOR OBTAINING ALKYLED OXIMES OF METHYL-2 (TENOYL OR FUROYLPHENOXY) -2-PROPIONIC ACIDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7704110A FR2380273A1 (en) 1977-02-14 1977-02-14 Imino-methyl-phenoxy-propionic acid derivs. - useful as hypocholesterolaemics, hypolipidaemics and uricosurics

Publications (2)

Publication Number Publication Date
FR2380273A1 true FR2380273A1 (en) 1978-09-08
FR2380273B1 FR2380273B1 (en) 1981-01-09

Family

ID=9186702

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7704110A Granted FR2380273A1 (en) 1977-02-14 1977-02-14 Imino-methyl-phenoxy-propionic acid derivs. - useful as hypocholesterolaemics, hypolipidaemics and uricosurics

Country Status (3)

Country Link
AT (1) AT365585B (en)
FR (1) FR2380273A1 (en)
ZA (1) ZA78608B (en)

Also Published As

Publication number Publication date
AT365585B (en) 1982-01-25
ATA95478A (en) 1981-06-15
ZA78608B (en) 1978-12-27
FR2380273B1 (en) 1981-01-09

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