FR2379541A1 - Pyridyl or isoquinolyl imino-di:hydro-thiazolo(3,4-a):indole cpds. - used as analgesics, antiinflammatories and antipyretics and prepd. from the thiazolo:indolium salt and amino-pyridine or amino-isoquinoline - Google Patents

Pyridyl or isoquinolyl imino-di:hydro-thiazolo(3,4-a):indole cpds. - used as analgesics, antiinflammatories and antipyretics and prepd. from the thiazolo:indolium salt and amino-pyridine or amino-isoquinoline

Info

Publication number
FR2379541A1
FR2379541A1 FR7703186A FR7703186A FR2379541A1 FR 2379541 A1 FR2379541 A1 FR 2379541A1 FR 7703186 A FR7703186 A FR 7703186A FR 7703186 A FR7703186 A FR 7703186A FR 2379541 A1 FR2379541 A1 FR 2379541A1
Authority
FR
France
Prior art keywords
thiazolo
amino
pyridyl
antiinflammatories
antipyretics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7703186A
Other languages
French (fr)
Other versions
FR2379541B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7703186A priority Critical patent/FR2379541A1/en
Priority to NL7800385A priority patent/NL7800385A/en
Priority to BE184455A priority patent/BE863084A/en
Priority to CA295,295A priority patent/CA1080714A/en
Priority to LU78894A priority patent/LU78894A1/en
Priority to DK27278A priority patent/DK143280C/en
Priority to HU78RO959A priority patent/HU174220B/en
Priority to AT39478A priority patent/AT361916B/en
Priority to CH56278A priority patent/CH626371A5/fr
Priority to GB2240/78A priority patent/GB1574271A/en
Priority to SE7800682A priority patent/SE7800682L/en
Priority to DE19782802520 priority patent/DE2802520A1/en
Priority to JP511278A priority patent/JPS53130694A/en
Priority to AU32610/78A priority patent/AU513767B2/en
Priority to ZA00780383A priority patent/ZA78383B/en
Priority to IE127/78A priority patent/IE46247B1/en
Priority to US05/871,133 priority patent/US4153699A/en
Publication of FR2379541A1 publication Critical patent/FR2379541A1/en
Application granted granted Critical
Publication of FR2379541B1 publication Critical patent/FR2379541B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

3-Heterocyclylimino-9, 9a-dihydro-thiazolo (3, 4-a)-indole derivs. of formula (I) in the (R) or a (s) forms or their mixts. and theri acid addn. salts are new. In (I) A is 3-pyridyl, 4-pyridyl or 5-isoquinolyl (opt. substd. in posn. 3 by an opt. branched 1-10C alkyl. (I) are analgesics, antipyretics and antiinflammatories used to treat chronic and acute pain e.g. rheumatic, traumatic, dental, neurological, visceral, cancer etc.; inflammatory troubles e.g. spondytarthritis, ankylosis, acute articular rheumatism, arthroses etc. and febrile states by oral, rectal, parenteral or topical application e.g. in doses of 150-2000 mg/day.
FR7703186A 1977-02-04 1977-02-04 Pyridyl or isoquinolyl imino-di:hydro-thiazolo(3,4-a):indole cpds. - used as analgesics, antiinflammatories and antipyretics and prepd. from the thiazolo:indolium salt and amino-pyridine or amino-isoquinoline Granted FR2379541A1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR7703186A FR2379541A1 (en) 1977-02-04 1977-02-04 Pyridyl or isoquinolyl imino-di:hydro-thiazolo(3,4-a):indole cpds. - used as analgesics, antiinflammatories and antipyretics and prepd. from the thiazolo:indolium salt and amino-pyridine or amino-isoquinoline
NL7800385A NL7800385A (en) 1977-02-04 1978-01-12 NEW INDOLIC DERIVATIVES, METHODS FOR PREPARING THEM AND PREPARATIONS CONTAINING THE NEW DERIVATIVES.
GB2240/78A GB1574271A (en) 1977-02-04 1978-01-19 Thiazole (3,4- )indole derivatives
LU78894A LU78894A1 (en) 1977-02-04 1978-01-19 NEW INDOLE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
DK27278A DK143280C (en) 1977-02-04 1978-01-19 ANALOGY PROCEDURE FOR THE PREPARATION OF 9,9A-DIHYDROTHIAZOLO (3,4-A) INCIDENTAL DERIVATIVES
HU78RO959A HU174220B (en) 1977-02-04 1978-01-19 Process for producing new thiasolo-indole derivatives
AT39478A AT361916B (en) 1977-02-04 1978-01-19 METHOD FOR PRODUCING NEW 3-IMINO-9.9A DIHYDROTHIAZOLO (3,4-A) INDOLE DERIVATIVES AND THEIR SALTS
CH56278A CH626371A5 (en) 1977-02-04 1978-01-19
BE184455A BE863084A (en) 1977-02-04 1978-01-19 NEW INDOLE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
SE7800682A SE7800682L (en) 1977-02-04 1978-01-19 PROCEDURE FOR PREPARING NEW CONTENT DERIVATIVES
CA295,295A CA1080714A (en) 1977-02-04 1978-01-19 Derivatives of indole, their preparation and compositions thereof
DE19782802520 DE2802520A1 (en) 1977-02-04 1978-01-20 NEW DERIVATIVES OF INDOL, THEIR PRODUCTION AND THE COMPOSITIONS THEREOF
JP511278A JPS53130694A (en) 1977-02-04 1978-01-20 Thtazolo*3*44a*indole derivative and process for preparing same
AU32610/78A AU513767B2 (en) 1977-02-04 1978-01-20 Thiazolo (3, 4-a) indole derivatives
ZA00780383A ZA78383B (en) 1977-02-04 1978-01-20 Thiazolo(3,4-a)indole derivatives
IE127/78A IE46247B1 (en) 1977-02-04 1978-01-20 Thiazolo(3,4-a)indole derivatives
US05/871,133 US4153699A (en) 1977-02-04 1978-01-20 Thiazolo[3,4-a]indole derivatives and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7703186A FR2379541A1 (en) 1977-02-04 1977-02-04 Pyridyl or isoquinolyl imino-di:hydro-thiazolo(3,4-a):indole cpds. - used as analgesics, antiinflammatories and antipyretics and prepd. from the thiazolo:indolium salt and amino-pyridine or amino-isoquinoline

Publications (2)

Publication Number Publication Date
FR2379541A1 true FR2379541A1 (en) 1978-09-01
FR2379541B1 FR2379541B1 (en) 1980-11-21

Family

ID=9186315

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7703186A Granted FR2379541A1 (en) 1977-02-04 1977-02-04 Pyridyl or isoquinolyl imino-di:hydro-thiazolo(3,4-a):indole cpds. - used as analgesics, antiinflammatories and antipyretics and prepd. from the thiazolo:indolium salt and amino-pyridine or amino-isoquinoline

Country Status (3)

Country Link
JP (1) JPS53130694A (en)
FR (1) FR2379541A1 (en)
ZA (1) ZA78383B (en)

Also Published As

Publication number Publication date
ZA78383B (en) 1979-01-31
JPS53130694A (en) 1978-11-14
FR2379541B1 (en) 1980-11-21

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