FR2378746A1 - Antihypertensive alpha-amino-di:halophenyl derivs. - prepd. from a benzyl halide and 2-isocyano propionate - Google Patents

Antihypertensive alpha-amino-di:halophenyl derivs. - prepd. from a benzyl halide and 2-isocyano propionate

Info

Publication number
FR2378746A1
FR2378746A1 FR7702360A FR7702360A FR2378746A1 FR 2378746 A1 FR2378746 A1 FR 2378746A1 FR 7702360 A FR7702360 A FR 7702360A FR 7702360 A FR7702360 A FR 7702360A FR 2378746 A1 FR2378746 A1 FR 2378746A1
Authority
FR
France
Prior art keywords
derivs
isocyano
prepd
propionate
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7702360A
Other languages
French (fr)
Other versions
FR2378746B1 (en
Inventor
Michael John Dimsdale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7702360A priority Critical patent/FR2378746A1/en
Publication of FR2378746A1 publication Critical patent/FR2378746A1/en
Application granted granted Critical
Publication of FR2378746B1 publication Critical patent/FR2378746B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds

Abstract

alpha-Amino acid dihalophenyl derivs. of formula (I) their esters and salts in racemic or optically active forms, are new. In (I), R1-2 are F, Cl, Br or CF3; R3 is H or OH; R4 is H or 1-4C alkyl. A typical cpd. is the methyl ester of dl-3-(3,4-dichlorophenyl)-2-methyl alanine. In an example this was prepd. by treating methyl-2-isocyano propionate with NaH in THF and adding 3,4-dichlorobenzyl bromide.
FR7702360A 1977-01-28 1977-01-28 Antihypertensive alpha-amino-di:halophenyl derivs. - prepd. from a benzyl halide and 2-isocyano propionate Granted FR2378746A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7702360A FR2378746A1 (en) 1977-01-28 1977-01-28 Antihypertensive alpha-amino-di:halophenyl derivs. - prepd. from a benzyl halide and 2-isocyano propionate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7702360A FR2378746A1 (en) 1977-01-28 1977-01-28 Antihypertensive alpha-amino-di:halophenyl derivs. - prepd. from a benzyl halide and 2-isocyano propionate

Publications (2)

Publication Number Publication Date
FR2378746A1 true FR2378746A1 (en) 1978-08-25
FR2378746B1 FR2378746B1 (en) 1983-06-03

Family

ID=9185997

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7702360A Granted FR2378746A1 (en) 1977-01-28 1977-01-28 Antihypertensive alpha-amino-di:halophenyl derivs. - prepd. from a benzyl halide and 2-isocyano propionate

Country Status (1)

Country Link
FR (1) FR2378746A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271187A (en) * 1978-06-05 1981-06-02 Merck & Co., Inc. Substituted phenyl alanine antihypertensive agents
US5348980A (en) * 1992-05-05 1994-09-20 Institute De Recherche Jouveinal Enantiomers derived from (S)-2-amino-2-(3,4-dichlorobenzyl)-1-propanol, their use and method of preparation
US5472970A (en) * 1992-05-05 1995-12-05 Institut De Recherche Jouveinal S.A. Allylaminoesters and their application in therapeutics
FR2761686A1 (en) * 1997-04-07 1998-10-09 Sipsy Sa NOVEL PROCESS FOR PREPARING (+/-) 3- (3,4-DICHLOROPHENYL) -2-DIMETHYLAMINO-2-METHYL-PROPAN-1-OL OR CERICLAMINE (INN)
JP3142627B2 (en) 1991-03-27 2001-03-07 セルジーン・コーポレーション Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acid
WO2015152128A1 (en) * 2014-03-31 2015-10-08 長瀬産業株式会社 Amino acid precursor, amino acid, and production method for amino acid, and pet diagnostic tracer using amino acid

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271187A (en) * 1978-06-05 1981-06-02 Merck & Co., Inc. Substituted phenyl alanine antihypertensive agents
JP3142627B2 (en) 1991-03-27 2001-03-07 セルジーン・コーポレーション Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acid
US5348980A (en) * 1992-05-05 1994-09-20 Institute De Recherche Jouveinal Enantiomers derived from (S)-2-amino-2-(3,4-dichlorobenzyl)-1-propanol, their use and method of preparation
US5472970A (en) * 1992-05-05 1995-12-05 Institut De Recherche Jouveinal S.A. Allylaminoesters and their application in therapeutics
FR2761686A1 (en) * 1997-04-07 1998-10-09 Sipsy Sa NOVEL PROCESS FOR PREPARING (+/-) 3- (3,4-DICHLOROPHENYL) -2-DIMETHYLAMINO-2-METHYL-PROPAN-1-OL OR CERICLAMINE (INN)
WO1998045248A1 (en) * 1997-04-07 1998-10-15 Jouveinal Novel process for the preparation of (+/-)3- (3,4-dichlorophenyl)-2- dimethylamino-2-methylpropan-1-ol or cericlamine (inn)
US6121491A (en) * 1997-04-07 2000-09-19 Warner-Lambert Company Process for the preparation of (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-OL or cericlamine (INN)
WO2015152128A1 (en) * 2014-03-31 2015-10-08 長瀬産業株式会社 Amino acid precursor, amino acid, and production method for amino acid, and pet diagnostic tracer using amino acid

Also Published As

Publication number Publication date
FR2378746B1 (en) 1983-06-03

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