FR2375195A1 - Camphoric acid mono-amide derivs. - with choleretic, gallstone-dissolving and pancreatic enzyme secretion stimulating activity - Google Patents

Camphoric acid mono-amide derivs. - with choleretic, gallstone-dissolving and pancreatic enzyme secretion stimulating activity

Info

Publication number
FR2375195A1
FR2375195A1 FR7738981A FR7738981A FR2375195A1 FR 2375195 A1 FR2375195 A1 FR 2375195A1 FR 7738981 A FR7738981 A FR 7738981A FR 7738981 A FR7738981 A FR 7738981A FR 2375195 A1 FR2375195 A1 FR 2375195A1
Authority
FR
France
Prior art keywords
mono
alkylene
choleretic
gallstone
dissolving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738981A
Other languages
French (fr)
Other versions
FR2375195B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Natterman und Cie GmbH
Original Assignee
A Natterman und Cie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Natterman und Cie GmbH filed Critical A Natterman und Cie GmbH
Publication of FR2375195A1 publication Critical patent/FR2375195A1/en
Application granted granted Critical
Publication of FR2375195B1 publication Critical patent/FR2375195B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

New cyclopentane carboxylic acid derivs. have formula (I): In (I), X is H, an alkali metal atom, or a suitable organic base, R1 is H or 1-3C alkyl, and R2 is 2-8C alkyl, 2-3C hydroxyalkyl, carboxyalkyl, alkoxyalkyl isoalkoxyalkyl, aryl, hydroxyaryl, carboxyaryl, carbalkoxyaryl, nomo- or dialkylaryl, mono- or dihaloaryl, alkoxyaryl, mono- or diarylalkyl, halo-aralkyl, mono- or dihydroxyaralkyl mono- or dialkyloxyaralkyl, hetoroaryl (esp. pyridyl), or heteroaryl-alkyl (esp. furfuryl), or R1 + R2 is 4-6C alkylene or 3-5C alkylene-thioalkylene or alkylene-amino-alkylene. Specific. cpds. (I) include that in which X and R1 are H and R2 is furfuryl. In an example, this is prepd. by refluxing 91-1g d-camphoric acid anhydride 4 hrs. with 48.6g furfurylamine in 300 ml toluene. Yield 62.6%.
FR7738981A 1976-12-27 1977-12-23 Camphoric acid mono-amide derivs. - with choleretic, gallstone-dissolving and pancreatic enzyme secretion stimulating activity Granted FR2375195A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762659052 DE2659052A1 (en) 1976-12-27 1976-12-27 N-SUBSTITUTED 1,2,2-TRIMETHYL-3-CARBAMOYL-CYCLOPENTANE-CARBONIC ACIDS (1) AND THEIR PHYSIOLOGICALLY COMPATIBLE SALTS

Publications (2)

Publication Number Publication Date
FR2375195A1 true FR2375195A1 (en) 1978-07-21
FR2375195B1 FR2375195B1 (en) 1981-07-24

Family

ID=5996769

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738981A Granted FR2375195A1 (en) 1976-12-27 1977-12-23 Camphoric acid mono-amide derivs. - with choleretic, gallstone-dissolving and pancreatic enzyme secretion stimulating activity

Country Status (5)

Country Link
JP (1) JPS5392737A (en)
AT (1) AT351502B (en)
DE (1) DE2659052A1 (en)
FR (1) FR2375195A1 (en)
ZA (1) ZA777604B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008017840A1 (en) * 2006-08-08 2008-02-14 Merlion Pharmaceuticals Sa Cyclopentanecarboxylic acid derivatives and their use in the treatment of bacterial infectious diseases
MX2011007340A (en) * 2009-01-09 2011-07-21 Orchid Res Lab Ltd Dipeptidyl peptidase iv inhibitors.

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CA1931 *
CA1961 *
NV161/36 *
NV914/62 *

Also Published As

Publication number Publication date
DE2659052A1 (en) 1978-07-06
ZA777604B (en) 1978-11-29
ATA933477A (en) 1979-01-15
AT351502B (en) 1979-07-25
JPS5392737A (en) 1978-08-15
FR2375195B1 (en) 1981-07-24

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Legal Events

Date Code Title Description
ST Notification of lapse