FR2370473A1 - Azetidine compsn. for treating psoriasis - contg. 3-hydrocarbyl-sulphonyloxy-azetidine derivs. formulated e.g. as topical compsn. - Google Patents

Azetidine compsn. for treating psoriasis - contg. 3-hydrocarbyl-sulphonyloxy-azetidine derivs. formulated e.g. as topical compsn.

Info

Publication number
FR2370473A1
FR2370473A1 FR7733934A FR7733934A FR2370473A1 FR 2370473 A1 FR2370473 A1 FR 2370473A1 FR 7733934 A FR7733934 A FR 7733934A FR 7733934 A FR7733934 A FR 7733934A FR 2370473 A1 FR2370473 A1 FR 2370473A1
Authority
FR
France
Prior art keywords
azetidine
compsn
treating psoriasis
formulated
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7733934A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of FR2370473A1 publication Critical patent/FR2370473A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pharmaceutical compsn. contains as active ingredient an azetidine deriv. of formula (I) or its acid addn. salts. In (I) R1 is H, 3-18C alkyl, 5-15C cycloalkyl, 1- or 2-adamantyl, benzylhydryl, benzyl (opt. substd. by 2, same, OH, alkoxy or benzoyloxy), 3-(5 alpha-cholestanyl) or 3-(17-oxy-5 alpha-androstanyl. R2 is 1-18C alkyl, benzyl or tolyl. R3 and R4 are each H or 1-4C alkyl. (I) and their salts are new when R1 is 3-(5 alpha-cholestanyl) or 3-(17-3xy-5 alpha-androstanyl). Also new are the maleate and hemimaleate of 1-isopropyl3-methanesulphonyloxyazetidine (Ia). (I) are used in treating psoriasis and are formulated in conventional topical or sub-cutaneous formulations. The usual dose is 0.1-5 mg/kg/day for treating psoriasis, mycoses or vitiligo.
FR7733934A 1976-11-12 1977-11-10 Azetidine compsn. for treating psoriasis - contg. 3-hydrocarbyl-sulphonyloxy-azetidine derivs. formulated e.g. as topical compsn. Withdrawn FR2370473A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74158276A 1976-11-12 1976-11-12

Publications (1)

Publication Number Publication Date
FR2370473A1 true FR2370473A1 (en) 1978-06-09

Family

ID=24981316

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7733934A Withdrawn FR2370473A1 (en) 1976-11-12 1977-11-10 Azetidine compsn. for treating psoriasis - contg. 3-hydrocarbyl-sulphonyloxy-azetidine derivs. formulated e.g. as topical compsn.

Country Status (9)

Country Link
JP (1) JPS5363369A (en)
AU (1) AU3057577A (en)
BE (1) BE860705A (en)
DE (1) DE2750300A1 (en)
FR (1) FR2370473A1 (en)
IL (1) IL53351A0 (en)
NL (1) NL7712444A (en)
NZ (1) NZ185661A (en)
ZA (1) ZA776725B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2649100B1 (en) * 1989-06-29 1994-03-04 Laboratorios Dr Esteve Sa NOVEL AZETIDINES, THEIR PREPARATION AND THEIR APPLICATION AS INTERMEDIATES FOR THE PREPARATION OF COMPOUNDS WITH ANTIMICROBIAL ACTIVITY

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2077681A1 (en) * 1970-02-24 1971-11-05 Takeda Chemical Industries Ltd N-substd azetidin-3-sulphonates-sedatives - and inters for guanidino-azetidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2077681A1 (en) * 1970-02-24 1971-11-05 Takeda Chemical Industries Ltd N-substd azetidin-3-sulphonates-sedatives - and inters for guanidino-azetidines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NCA1972 *

Also Published As

Publication number Publication date
BE860705A (en) 1978-05-10
JPS5363369A (en) 1978-06-06
DE2750300A1 (en) 1978-05-18
NL7712444A (en) 1978-05-17
IL53351A0 (en) 1978-01-31
ZA776725B (en) 1978-09-27
AU3057577A (en) 1979-05-17
NZ185661A (en) 1980-09-12

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Legal Events

Date Code Title Description
ST Notification of lapse