FR2365585A1 - NEW 1-SUBSTITUTE GLYCOPYRANOSIDES WITH INSULIN-TYPE ACTIVITY - Google Patents

NEW 1-SUBSTITUTE GLYCOPYRANOSIDES WITH INSULIN-TYPE ACTIVITY

Info

Publication number
FR2365585A1
FR2365585A1 FR7728934A FR7728934A FR2365585A1 FR 2365585 A1 FR2365585 A1 FR 2365585A1 FR 7728934 A FR7728934 A FR 7728934A FR 7728934 A FR7728934 A FR 7728934A FR 2365585 A1 FR2365585 A1 FR 2365585A1
Authority
FR
France
Prior art keywords
glycopyranosides
deoxy
omega
insulin
substitute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7728934A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2365585A1 publication Critical patent/FR2365585A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne de nouveaux 1-désoxy-glycopyranosides, de préférence des 1-désoxy-D-mannopyranosides, ayant dans la position 1 du noyau de pyranoside un substituant oméga-aminoalcoylthio, oméga-aminoalcoylozy ou oméga-aminoalcanoylamino. On prépare ces 1-substitué- l-désoxy-glycopyranosides à partir du bromure de tétra-O-acétylglycopyranosyle ou de la tétraO-acétyl-glycopyranosyl amine correspondants. Ces oméga-amino (alcoylthio, alcoyloxy ou alcanoylamino)- 1-désoxy-glycopyranosides, et en particulier les 1-Ø(6'-amino-hexyl) thio ou oxyõ- 1-désoxy-D-mannopyranorides, possèdent une activité semblable à celle de l'insuline.The invention relates to novel 1-deoxy-glycopyranosides, preferably 1-deoxy-D-mannopyranosides, having in position 1 of the pyranoside ring an omega-aminoalkylthio, omega-aminoalkylozy or omega-aminoalkanoylamino substituent. These 1-substituted-1-deoxy-glycopyranosides are prepared from the corresponding tetra-O-acetylglycopyranosyl bromide or tetraO-acetyl-glycopyranosyl amine. These omega-amino (alkylthio, alkyloxy or alkanoylamino) - 1-deoxy-glycopyranosides, and in particular 1-Ø (6'-amino-hexyl) thio or oxyõ- 1-deoxy-D-mannopyranorides, have an activity similar to that of insulin.

FR7728934A 1976-09-28 1977-09-26 NEW 1-SUBSTITUTE GLYCOPYRANOSIDES WITH INSULIN-TYPE ACTIVITY Withdrawn FR2365585A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72755176A 1976-09-28 1976-09-28

Publications (1)

Publication Number Publication Date
FR2365585A1 true FR2365585A1 (en) 1978-04-21

Family

ID=24923103

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7728934A Withdrawn FR2365585A1 (en) 1976-09-28 1977-09-26 NEW 1-SUBSTITUTE GLYCOPYRANOSIDES WITH INSULIN-TYPE ACTIVITY

Country Status (5)

Country Link
JP (1) JPS53108913A (en)
DE (1) DE2742955A1 (en)
FR (1) FR2365585A1 (en)
GB (1) GB1574073A (en)
NL (1) NL7710142A (en)

Also Published As

Publication number Publication date
DE2742955A1 (en) 1978-03-30
NL7710142A (en) 1978-03-30
JPS53108913A (en) 1978-09-22
GB1574073A (en) 1980-09-03

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Legal Events

Date Code Title Description
ST Notification of lapse