FR2364939A2 - Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol - Google Patents

Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol

Info

Publication number
FR2364939A2
FR2364939A2 FR7628396A FR7628396A FR2364939A2 FR 2364939 A2 FR2364939 A2 FR 2364939A2 FR 7628396 A FR7628396 A FR 7628396A FR 7628396 A FR7628396 A FR 7628396A FR 2364939 A2 FR2364939 A2 FR 2364939A2
Authority
FR
France
Prior art keywords
heparin
contg
polymers
prepd
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7628396A
Other languages
French (fr)
Other versions
FR2364939B2 (en
Inventor
Christian Pusineri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7628396A priority Critical patent/FR2364939A2/en
Publication of FR2364939A2 publication Critical patent/FR2364939A2/en
Application granted granted Critical
Publication of FR2364939B2 publication Critical patent/FR2364939B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0023—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a quaternized group or a protonated amine group of the substrate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/0804—Manufacture of polymers containing ionic or ionogenic groups
    • C08G18/0809—Manufacture of polymers containing ionic or ionogenic groups containing cationic or cationogenic groups
    • C08G18/0814—Manufacture of polymers containing ionic or ionogenic groups containing cationic or cationogenic groups containing ammonium groups or groups forming them

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Manufacturing & Machinery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Heparin is bonded to polymers contg. a quat. ammonium group in a polar aprotic solvent, the heparination being effected in the preference of water and dimethyl sulphoxide and/or diethyl glycol. Useful as anticoagulants. In an example, a polyurethane contg. 0.583 m.eq./g of tert. N was treated in DMF with CH3I to give 100% yield of quat. N. This was then treated with the Na salt of heparin in water and DMSO giving a polyurethane contg. 16.6% heparin.
FR7628396A 1976-09-16 1976-09-16 Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol Granted FR2364939A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7628396A FR2364939A2 (en) 1976-09-16 1976-09-16 Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7628396A FR2364939A2 (en) 1976-09-16 1976-09-16 Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol

Publications (2)

Publication Number Publication Date
FR2364939A2 true FR2364939A2 (en) 1978-04-14
FR2364939B2 FR2364939B2 (en) 1981-07-31

Family

ID=9177924

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7628396A Granted FR2364939A2 (en) 1976-09-16 1976-09-16 Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol

Country Status (1)

Country Link
FR (1) FR2364939A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676975A (en) * 1984-12-07 1987-06-30 Becton, Dickinson And Company Thermoplastic polyurethane anticoagulant alloy coating
US4678660A (en) * 1984-12-07 1987-07-07 Deseret Medical, Inc. Thermoplastic polyurethane anticoagulant alloy coating
EP0495478A2 (en) * 1991-01-16 1992-07-22 Toyo Boseki Kabushiki Kaisha A material compatible with blood

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2087506A5 (en) * 1970-05-21 1971-12-31 Rhone Poulenc Sa
US3755218A (en) * 1970-08-14 1973-08-28 California Inst Of Techn Ionically bonded block elastomeric copolymers of a polyquaternary polyurethane and heparin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2087506A5 (en) * 1970-05-21 1971-12-31 Rhone Poulenc Sa
US3755218A (en) * 1970-08-14 1973-08-28 California Inst Of Techn Ionically bonded block elastomeric copolymers of a polyquaternary polyurethane and heparin

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676975A (en) * 1984-12-07 1987-06-30 Becton, Dickinson And Company Thermoplastic polyurethane anticoagulant alloy coating
US4678660A (en) * 1984-12-07 1987-07-07 Deseret Medical, Inc. Thermoplastic polyurethane anticoagulant alloy coating
EP0495478A2 (en) * 1991-01-16 1992-07-22 Toyo Boseki Kabushiki Kaisha A material compatible with blood
EP0495478A3 (en) * 1991-01-16 1993-04-21 Toyo Boseki Kabushiki Kaisha A material compatible with blood
US5541305A (en) * 1991-01-16 1996-07-30 Toyo Boseki Kabushiki Kaisha Composition compatible with blood

Also Published As

Publication number Publication date
FR2364939B2 (en) 1981-07-31

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