FR2354351A1 - Hydrophilic polymeric microporous gels - used for separating aminoacid enantiomer(s) by high-pressure liq. chromatography - Google Patents

Hydrophilic polymeric microporous gels - used for separating aminoacid enantiomer(s) by high-pressure liq. chromatography

Info

Publication number
FR2354351A1
FR2354351A1 FR7617560A FR7617560A FR2354351A1 FR 2354351 A1 FR2354351 A1 FR 2354351A1 FR 7617560 A FR7617560 A FR 7617560A FR 7617560 A FR7617560 A FR 7617560A FR 2354351 A1 FR2354351 A1 FR 2354351A1
Authority
FR
France
Prior art keywords
enantiomer
hydrophilic polymeric
aminoacid
chromatography
separating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7617560A
Other languages
French (fr)
Other versions
FR2354351B1 (en
Inventor
Claude Quivoron
Roland Audebert
Bernard Lefebvre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7617560A priority Critical patent/FR2354351A1/en
Publication of FR2354351A1 publication Critical patent/FR2354351A1/en
Application granted granted Critical
Publication of FR2354351B1 publication Critical patent/FR2354351B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52—Amides or imides
    • C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Resin for chromatographic sepn. of enantiomers comprising a hydrophilic polymeric macroporous gel contg. units of formula - CH2-CH - (where R is an asymmetric organic group). A typical resn was prepd. by suspending methylol-acrylamide, methylene-bis-acrylamide, potassium persulphate and a surfactant in water, mixing with cyclohexane and refluxing for 30 min. to give beads, 60% of 10-40 mu dia. Resolution of products of biosynthesis, esp. aminoacids in which biological activity usually resides in one enantiomer only.
FR7617560A 1976-06-10 1976-06-10 Hydrophilic polymeric microporous gels - used for separating aminoacid enantiomer(s) by high-pressure liq. chromatography Granted FR2354351A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7617560A FR2354351A1 (en) 1976-06-10 1976-06-10 Hydrophilic polymeric microporous gels - used for separating aminoacid enantiomer(s) by high-pressure liq. chromatography

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7617560A FR2354351A1 (en) 1976-06-10 1976-06-10 Hydrophilic polymeric microporous gels - used for separating aminoacid enantiomer(s) by high-pressure liq. chromatography

Publications (2)

Publication Number Publication Date
FR2354351A1 true FR2354351A1 (en) 1978-01-06
FR2354351B1 FR2354351B1 (en) 1979-06-22

Family

ID=9174209

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7617560A Granted FR2354351A1 (en) 1976-06-10 1976-06-10 Hydrophilic polymeric microporous gels - used for separating aminoacid enantiomer(s) by high-pressure liq. chromatography

Country Status (1)

Country Link
FR (1) FR2354351A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218089A1 (en) * 1985-09-11 1987-04-15 Bayer Ag Optically active (meth)-acryl amide, polymers thereof, process for their preparation and their use in the separation of racemates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218089A1 (en) * 1985-09-11 1987-04-15 Bayer Ag Optically active (meth)-acryl amide, polymers thereof, process for their preparation and their use in the separation of racemates
US4931525A (en) * 1985-09-11 1990-06-05 Bayer Aktiengesellschaft Optical active (meth)acrylamides and polymers thereof for racemate resolution

Also Published As

Publication number Publication date
FR2354351B1 (en) 1979-06-22

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Legal Events

Date Code Title Description
ST Notification of lapse