FR2346353A1 - Composes de la xanthine et procedes de traitement de maladies bronchospastiques et allergiques - Google Patents

Composes de la xanthine et procedes de traitement de maladies bronchospastiques et allergiques

Info

Publication number
FR2346353A1
FR2346353A1 FR7709680A FR7709680A FR2346353A1 FR 2346353 A1 FR2346353 A1 FR 2346353A1 FR 7709680 A FR7709680 A FR 7709680A FR 7709680 A FR7709680 A FR 7709680A FR 2346353 A1 FR2346353 A1 FR 2346353A1
Authority
FR
France
Prior art keywords
xanthin
compounds
methods
allergic diseases
bronchospastic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7709680A
Other languages
English (en)
French (fr)
Other versions
FR2346353B1 (cs
Inventor
Julius Diamond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cooper Laboratories Inc
Original Assignee
Cooper Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/672,388 external-priority patent/US4120947A/en
Priority claimed from US05/672,437 external-priority patent/US4089959A/en
Application filed by Cooper Laboratories Inc filed Critical Cooper Laboratories Inc
Publication of FR2346353A1 publication Critical patent/FR2346353A1/fr
Application granted granted Critical
Publication of FR2346353B1 publication Critical patent/FR2346353B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7709680A 1976-03-31 1977-03-31 Composes de la xanthine et procedes de traitement de maladies bronchospastiques et allergiques Granted FR2346353A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/672,388 US4120947A (en) 1976-03-31 1976-03-31 Xanthine compounds and method of treating bronchospastic and allergic diseases
US05/672,437 US4089959A (en) 1976-03-31 1976-03-31 Long-acting xanthine bronchodilators and antiallergy agents

Publications (2)

Publication Number Publication Date
FR2346353A1 true FR2346353A1 (fr) 1977-10-28
FR2346353B1 FR2346353B1 (cs) 1980-03-07

Family

ID=27100746

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7709680A Granted FR2346353A1 (fr) 1976-03-31 1977-03-31 Composes de la xanthine et procedes de traitement de maladies bronchospastiques et allergiques

Country Status (5)

Country Link
JP (1) JPS52122396A (cs)
CA (1) CA1077932A (cs)
DE (1) DE2713389A1 (cs)
FR (1) FR2346353A1 (cs)
GB (1) GB1561005A (cs)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0039780A1 (fr) * 1980-05-02 1981-11-18 Societe Des Produits Nestle S.A. Xanthines di- ou trisubstituées ayant des propriétés neuroleptiques, procédés de préparation et médicament les contenant
FR2611716A1 (fr) * 1987-03-06 1988-09-09 Uriach Cia Sa J Derives de diisobutylxanthine substituee en position 7 utiles comme bronchodilatateurs, procede pour leur preparation et composition pharmaceutique les contenant
EP0369744A3 (en) * 1988-11-14 1991-04-10 SMITHKLINE BEECHAM PHARMA GmbH Xanthine derivatives, process for their preparation and pharmaceutical compositions
EP0386683A3 (en) * 1989-03-10 1992-01-15 POLI INDUSTRIA CHIMICA S.p.A. Xanthine derivatives having bronchodilating activity, a process for the preparation thereof and pharmaceutical compositions containing them
US5321029A (en) * 1988-11-14 1994-06-14 Beecham-Wuelfing Gmbh & Co.K.G. Xanthines

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416810C (sv) * 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
SE7810946L (sv) * 1978-10-20 1980-04-21 Draco Ab Metod att behandla kronisk obstruktiv luftvegssjukdom
SE7810947L (sv) * 1978-10-20 1980-04-21 Draco Ab 3-alkylxanthines
SE8002910L (sv) * 1980-04-18 1981-10-19 Draco Ab 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
ATE247116T1 (de) * 1994-12-13 2003-08-15 Euro Celtique Sa Arylthioxanthine
ATE247655T1 (de) 1994-12-13 2003-09-15 Euro Celtique Sa Dreifachsubstituierte thioxanthine
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2729643A (en) * 1956-01-03 J-disubstmjied and i

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0039780A1 (fr) * 1980-05-02 1981-11-18 Societe Des Produits Nestle S.A. Xanthines di- ou trisubstituées ayant des propriétés neuroleptiques, procédés de préparation et médicament les contenant
FR2611716A1 (fr) * 1987-03-06 1988-09-09 Uriach Cia Sa J Derives de diisobutylxanthine substituee en position 7 utiles comme bronchodilatateurs, procede pour leur preparation et composition pharmaceutique les contenant
EP0369744A3 (en) * 1988-11-14 1991-04-10 SMITHKLINE BEECHAM PHARMA GmbH Xanthine derivatives, process for their preparation and pharmaceutical compositions
US5321029A (en) * 1988-11-14 1994-06-14 Beecham-Wuelfing Gmbh & Co.K.G. Xanthines
EP0386683A3 (en) * 1989-03-10 1992-01-15 POLI INDUSTRIA CHIMICA S.p.A. Xanthine derivatives having bronchodilating activity, a process for the preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE2713389A1 (de) 1977-10-13
FR2346353B1 (cs) 1980-03-07
DE2713389C2 (cs) 1992-03-19
GB1561005A (en) 1980-02-13
JPS52122396A (en) 1977-10-14
CA1077932A (en) 1980-05-20
JPS5720313B2 (cs) 1982-04-27

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse