FR2345464A1 - METHOD AND MUTANTS FOR THE PREPARATION OF ANDROSTA-1,4-DIENE-3,17-DIONE AND ANDROST-4-ENE-3,17-DIONE - Google Patents

METHOD AND MUTANTS FOR THE PREPARATION OF ANDROSTA-1,4-DIENE-3,17-DIONE AND ANDROST-4-ENE-3,17-DIONE

Info

Publication number
FR2345464A1
FR2345464A1 FR7705773A FR7705773A FR2345464A1 FR 2345464 A1 FR2345464 A1 FR 2345464A1 FR 7705773 A FR7705773 A FR 7705773A FR 7705773 A FR7705773 A FR 7705773A FR 2345464 A1 FR2345464 A1 FR 2345464A1
Authority
FR
France
Prior art keywords
dione
androsta
androst
ene
diene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7705773A
Other languages
French (fr)
Other versions
FR2345464B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2345464A1 publication Critical patent/FR2345464A1/en
Application granted granted Critical
Publication of FR2345464B1 publication Critical patent/FR2345464B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17

Abstract

A mixture of androsta-1,4-diene-3,17-dione and androst-4-ene-3,17-dione is obtained by culturing a microorganism mutant of Mycobacterium fortuitum or of Mycobacterium phlei, which is characterised by its capability for the selective degradation of steroids having 17-alkyl side chains having from 2 up to and including 10 carbon atoms and for the formation or accumulation of androsta-1,4-diene-3,17-dione and androst-4-ene-3,17-dione in the fermentation broth, in an aqueous nutrient medium under aerobic conditions in the presence of a steroid having from 2 up to and including 10 carbon atoms in the 17-alkyl side chain. The compounds obtained as desired final products when carrying out the process according to the invention are known steroid intermediates. These compounds are thus suitable as intermediates in the synthesis of suitable steroid hormones.
FR7705773A 1976-03-01 1977-02-28 METHOD AND MUTANTS FOR THE PREPARATION OF ANDROSTA-1,4-DIENE-3,17-DIONE AND ANDROST-4-ENE-3,17-DIONE Granted FR2345464A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66256376A 1976-03-01 1976-03-01

Publications (2)

Publication Number Publication Date
FR2345464A1 true FR2345464A1 (en) 1977-10-21
FR2345464B1 FR2345464B1 (en) 1982-06-04

Family

ID=24658223

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7705773A Granted FR2345464A1 (en) 1976-03-01 1977-02-28 METHOD AND MUTANTS FOR THE PREPARATION OF ANDROSTA-1,4-DIENE-3,17-DIONE AND ANDROST-4-ENE-3,17-DIONE

Country Status (9)

Country Link
JP (1) JPS60133884A (en)
CH (2) CH637993A5 (en)
DD (1) DD130789A5 (en)
DE (1) DE2703645C3 (en)
FR (1) FR2345464A1 (en)
IL (3) IL60476A (en)
MX (3) MX6933E (en)
NL (1) NL170435C (en)
PL (2) PL113212B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2408621A2 (en) * 1977-11-09 1979-06-08 Upjohn Co Mutant microorganisms for selectively degrading steroid(s) - to androstane-3,17-di:one derivs. by aerobic fermentation, are esp. of Mycobacterium genus
EP0008214A1 (en) * 1978-08-07 1980-02-20 The Upjohn Company Microorganisms and their use in producing androst-4-ene-3,17-dione

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189865C (en) * 1976-10-22 1993-08-16 Upjohn Co PROCESS FOR PREPARING ANDROST-4-AN-3,17-DION AND MICROORGANISMS USED THEREOF
DE3521111A1 (en) * 1985-06-10 1986-12-11 Schering AG, 1000 Berlin und 4709 Bergkamen METHOD FOR PRODUCING 4-ANDROSTEN-3,17-DION AND 1,4-ANDROSTADIENE-3,17-DION
DE3544662A1 (en) * 1985-12-13 1987-06-19 Schering Ag METHOD FOR PRODUCING 4-ANDROSTEN-3,17-DION AND 1,4-ANDROSTADIEN-3,17-DION
CN106282080B (en) * 2016-08-10 2019-09-03 江南大学 A kind of sterone C27- monooxygenase in new gold mycobacteria source and its application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1494461A (en) * 1965-09-23 1967-09-08 Richter Gedeon Vegyeszet Process for the preparation of steroids having a structure of 1, 4-diene-3, 17-diones
FR1497292A (en) * 1965-10-22 1967-10-06 Koninklijke Gist Spiritus Process for obtaining steroids not containing an earbon substituent in position 17
FR2313395A1 (en) * 1975-06-06 1976-12-31 Mitsubishi Chem Ind MICROBIOLOGICAL STEROID OXIDATION PROCESS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1494461A (en) * 1965-09-23 1967-09-08 Richter Gedeon Vegyeszet Process for the preparation of steroids having a structure of 1, 4-diene-3, 17-diones
FR1497292A (en) * 1965-10-22 1967-10-06 Koninklijke Gist Spiritus Process for obtaining steroids not containing an earbon substituent in position 17
FR2313395A1 (en) * 1975-06-06 1976-12-31 Mitsubishi Chem Ind MICROBIOLOGICAL STEROID OXIDATION PROCESS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1972 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2408621A2 (en) * 1977-11-09 1979-06-08 Upjohn Co Mutant microorganisms for selectively degrading steroid(s) - to androstane-3,17-di:one derivs. by aerobic fermentation, are esp. of Mycobacterium genus
EP0008214A1 (en) * 1978-08-07 1980-02-20 The Upjohn Company Microorganisms and their use in producing androst-4-ene-3,17-dione

Also Published As

Publication number Publication date
MX6933E (en) 1986-12-05
DE2703645A1 (en) 1977-09-08
IL51370A0 (en) 1977-04-29
PL196355A1 (en) 1978-01-02
IL60476A0 (en) 1980-09-16
JPS6141547B2 (en) 1986-09-16
JPS60133884A (en) 1985-07-17
IL51370A (en) 1981-06-29
CH637993A5 (en) 1983-08-31
NL7701346A (en) 1977-09-05
DE2703645C3 (en) 1981-11-12
MX4503E (en) 1982-05-24
PL111029B1 (en) 1980-08-30
DE2703645B2 (en) 1980-08-07
NL170435C (en) 1982-11-01
FR2345464B1 (en) 1982-06-04
MX6932E (en) 1986-12-05
DD130789A5 (en) 1978-05-03
NL170435B (en) 1982-06-01
PL113212B1 (en) 1980-11-29
CH638563A5 (en) 1983-09-30
IL60476A (en) 1981-06-29

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