FR2339606A1 - (4)-Heterocyclyl-benzopyranyl esters - useful as antihypertensives - Google Patents

(4)-Heterocyclyl-benzopyranyl esters - useful as antihypertensives

Info

Publication number
FR2339606A1
FR2339606A1 FR7701699A FR7701699A FR2339606A1 FR 2339606 A1 FR2339606 A1 FR 2339606A1 FR 7701699 A FR7701699 A FR 7701699A FR 7701699 A FR7701699 A FR 7701699A FR 2339606 A1 FR2339606 A1 FR 2339606A1
Authority
FR
France
Prior art keywords
antihypertensives
piperidino
ran
benzo
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7701699A
Other languages
French (fr)
Other versions
FR2339606B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3024/76A external-priority patent/GB1548221A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of FR2339606A1 publication Critical patent/FR2339606A1/en
Application granted granted Critical
Publication of FR2339606B1 publication Critical patent/FR2339606B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Chroman derivs. of formula (I) and their salts are new: (R9 = CH3 or C2H5, R10 = H or CH3, R11 = H or CH3, R12 = H, halo, 1-6C alkyl, 2-6 C alkenyl, 1-6C alkoxy, 2-6C alkenyloxy, 1-6C alkylthio, NO2, CF3, 2-7C acylamino or CN). R13 = R14 or R14O. R 14 = 18C hydrocarbyl opt. substd. by halo. X = bond, CH2, CH2CH2, CH2CH2CHi, CH=CH or O). Also claimed is the intermediate trans-4-piperidino-3,4-dihydro-2,2-dimethyl-7-nitro-2H-benzo(b)py- ran-3-ol (II) and its pharmaceutically acceptable acid addition salts. (I) are antihypertensives. They are given generally at 1-250, e.g. 2-100 mg/day for a 70 kg person, opt. together with beta-adrenergic blockers, diuretics and/or other antihypertensives. (II) also has antihypertensive action with minimal side effects on the heart. In an example trans-4-piperidino-3,4-dihydro-2,2-dimethyl-6-nitro-2H-benzo(b)py- ran-3-yl acerate was prepd. by acetylation of the 3-ol.
FR7701699A 1976-01-27 1977-01-21 (4)-Heterocyclyl-benzopyranyl esters - useful as antihypertensives Granted FR2339606A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3024/76A GB1548221A (en) 1976-01-27 1976-01-27 Trans-4-heterocycyl-3,4-dihydro-2h-benzo pyran-3-ol esters
GB1423976 1976-04-08

Publications (2)

Publication Number Publication Date
FR2339606A1 true FR2339606A1 (en) 1977-08-26
FR2339606B1 FR2339606B1 (en) 1981-01-16

Family

ID=26237940

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7701699A Granted FR2339606A1 (en) 1976-01-27 1977-01-21 (4)-Heterocyclyl-benzopyranyl esters - useful as antihypertensives

Country Status (9)

Country Link
JP (1) JPS5291866A (en)
AU (1) AU505768B2 (en)
DE (1) DE2702092A1 (en)
DK (1) DK31977A (en)
ES (1) ES454888A1 (en)
FR (1) FR2339606A1 (en)
IE (1) IE44588B1 (en)
NL (1) NL7700819A (en)
SE (1) SE7700824L (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795275B (en) * 1978-10-04 1980-09-24 Beecham Group Ltd Chromanol derivatives a process for their preparation and their use in pharmaceutical compositions
ZM7682A1 (en) * 1981-09-25 1983-05-23 Beecham Group Plc Active compounds
GB8313679D0 (en) * 1983-05-18 1983-06-22 Beecham Group Plc Active compounds
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8625185D0 (en) * 1986-10-21 1986-11-26 Beecham Group Plc Active compounds
US5352814A (en) * 1991-08-30 1994-10-04 Nissan Chemical Industries, Ltd. Asymmetric epoxidation reaction
WO2001021609A1 (en) 1999-09-24 2001-03-29 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
US6677371B1 (en) 1999-10-05 2004-01-13 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
DE60206505T2 (en) 2001-06-25 2006-07-06 Nissan Chemical Industries, Ltd. SUBSTITUTED BENZOPYRENE DERIVATIVES AGAINST ARRHYTMIA

Also Published As

Publication number Publication date
SE7700824L (en) 1977-07-28
DE2702092A1 (en) 1977-07-28
IE44588B1 (en) 1982-01-27
JPS5291866A (en) 1977-08-02
NL7700819A (en) 1977-07-29
AU2162577A (en) 1978-08-03
DK31977A (en) 1977-07-28
AU505768B2 (en) 1979-11-29
ES454888A1 (en) 1978-05-01
FR2339606B1 (en) 1981-01-16
IE44588L (en) 1977-07-27

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Legal Events

Date Code Title Description
ST Notification of lapse