FR2335198A1 - Vascular collagenous graft prosthesis succinylation - confers antiplatelet and antithrombogenic props - Google Patents

Vascular collagenous graft prosthesis succinylation - confers antiplatelet and antithrombogenic props

Info

Publication number
FR2335198A1
FR2335198A1 FR7538980A FR7538980A FR2335198A1 FR 2335198 A1 FR2335198 A1 FR 2335198A1 FR 7538980 A FR7538980 A FR 7538980A FR 7538980 A FR7538980 A FR 7538980A FR 2335198 A1 FR2335198 A1 FR 2335198A1
Authority
FR
France
Prior art keywords
vascular
succinylation
prosthesis
antithrombogenic
antiplatelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7538980A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SAWYER PHILIP
Original Assignee
SAWYER PHILIP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SAWYER PHILIP filed Critical SAWYER PHILIP
Priority to FR7538980A priority Critical patent/FR2335198A1/en
Publication of FR2335198A1 publication Critical patent/FR2335198A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Prostheses (AREA)

Abstract

The performance of a graft prosthesis is improved by making the prosthesis of collagen and increasing its net negative internal surface charge by succinylation. The (vascular) prosthesis is less susceptible to thrombosis. The collagen used may be a dialdehyde starch-tanned bovine collagen vascular heterograft (Johnson & Johnson). This is then treated with succinic anhyd. in basic soln. in the presence of a NaHCO3 buffer. Any positive charge remaining sterns from arginine and histidine residues both of which may be treated by reaction with phenyl glyoxal and diethyl pyrocarbonate resp.
FR7538980A 1975-12-19 1975-12-19 Vascular collagenous graft prosthesis succinylation - confers antiplatelet and antithrombogenic props Pending FR2335198A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7538980A FR2335198A1 (en) 1975-12-19 1975-12-19 Vascular collagenous graft prosthesis succinylation - confers antiplatelet and antithrombogenic props

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7538980A FR2335198A1 (en) 1975-12-19 1975-12-19 Vascular collagenous graft prosthesis succinylation - confers antiplatelet and antithrombogenic props

Publications (1)

Publication Number Publication Date
FR2335198A1 true FR2335198A1 (en) 1977-07-15

Family

ID=9163943

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7538980A Pending FR2335198A1 (en) 1975-12-19 1975-12-19 Vascular collagenous graft prosthesis succinylation - confers antiplatelet and antithrombogenic props

Country Status (1)

Country Link
FR (1) FR2335198A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2378504A1 (en) * 1976-05-10 1978-08-25 Sawyer Philip PROCEDURE FOR THE CONTROL OF THROMBOGENICITY OF VASCULAR PROSTHESES Grafted
EP0191994A1 (en) * 1985-01-22 1986-08-27 Koken Co. Ltd. Solution for use in viscosurgery and/or as a vitreous substitute

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2378504A1 (en) * 1976-05-10 1978-08-25 Sawyer Philip PROCEDURE FOR THE CONTROL OF THROMBOGENICITY OF VASCULAR PROSTHESES Grafted
EP0191994A1 (en) * 1985-01-22 1986-08-27 Koken Co. Ltd. Solution for use in viscosurgery and/or as a vitreous substitute

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