FR2331327A2 - Rapidly disintegrating griseofulvin tablets - using cross linked polyvinyl pyrrolidone as disintegrant - Google Patents

Rapidly disintegrating griseofulvin tablets - using cross linked polyvinyl pyrrolidone as disintegrant

Info

Publication number
FR2331327A2
FR2331327A2 FR7534965A FR7534965A FR2331327A2 FR 2331327 A2 FR2331327 A2 FR 2331327A2 FR 7534965 A FR7534965 A FR 7534965A FR 7534965 A FR7534965 A FR 7534965A FR 2331327 A2 FR2331327 A2 FR 2331327A2
Authority
FR
France
Prior art keywords
disintegrant
griseofulvin
polyvinyl pyrrolidone
cross linked
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7534965A
Other languages
French (fr)
Other versions
FR2331327B2 (en
Inventor
Saul S Kornblum
Samuel B Stoopak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7201038A external-priority patent/FR2121805B1/fr
Priority to DE19752549740 priority Critical patent/DE2549740A1/en
Priority to GB4603575A priority patent/GB1504553A/en
Priority to AT848175A priority patent/AT348132B/en
Priority to AU86516/75A priority patent/AU507575B2/en
Priority to NL7513230A priority patent/NL7513230A/en
Priority to BE161873A priority patent/BE835572A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to FR7534965A priority patent/FR2331327A2/en
Publication of FR2331327A2 publication Critical patent/FR2331327A2/en
Publication of FR2331327B2 publication Critical patent/FR2331327B2/fr
Application granted granted Critical
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Use of cross-linked polyvinylpyrrolidone as a deaggredating agent in tablets contg. a dispersion of griseofulvin in polyethylene glycol is new. The presence of cross-linked PVP not only improves the speed of disintegration in the digestive fluids but insures rapid dissolution of the griseofulvin. Pref. tablets contain 20-25% w/w of PVP. They may be made by dry or wet granulation.
FR7534965A 1972-01-13 1975-11-17 Rapidly disintegrating griseofulvin tablets - using cross linked polyvinyl pyrrolidone as disintegrant Granted FR2331327A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19752549740 DE2549740A1 (en) 1975-11-17 1975-11-06 NEW GALENIC FORMS AND METHODS FOR THEIR PRODUCTION
GB4603575A GB1504553A (en) 1975-11-17 1975-11-06 Tablet formulations
AT848175A AT348132B (en) 1975-11-17 1975-11-07 METHOD OF MANUFACTURING A TABLET FOR MEDICAL PURPOSES
AU86516/75A AU507575B2 (en) 1975-11-17 1975-11-11 Griseofulvin tablet
NL7513230A NL7513230A (en) 1975-11-17 1975-11-12 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL TABLETS.
BE161873A BE835572A (en) 1975-11-17 1975-11-13 SOLID DRUG COMPOSITION WITH RAPID DISAGGREGATION
FR7534965A FR2331327A2 (en) 1972-01-13 1975-11-17 Rapidly disintegrating griseofulvin tablets - using cross linked polyvinyl pyrrolidone as disintegrant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7201038A FR2121805B1 (en) 1971-01-13 1972-01-13
FR7534965A FR2331327A2 (en) 1972-01-13 1975-11-17 Rapidly disintegrating griseofulvin tablets - using cross linked polyvinyl pyrrolidone as disintegrant

Publications (2)

Publication Number Publication Date
FR2331327A2 true FR2331327A2 (en) 1977-06-10
FR2331327B2 FR2331327B2 (en) 1979-09-21

Family

ID=26216837

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7534965A Granted FR2331327A2 (en) 1972-01-13 1975-11-17 Rapidly disintegrating griseofulvin tablets - using cross linked polyvinyl pyrrolidone as disintegrant

Country Status (1)

Country Link
FR (1) FR2331327A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (en) * 1978-11-20 1980-06-25 American Home Products Corporation Therapeutic compositions with enhanced bioavailability and process for their preparation
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (en) * 1978-11-20 1980-06-25 American Home Products Corporation Therapeutic compositions with enhanced bioavailability and process for their preparation
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability

Also Published As

Publication number Publication date
FR2331327B2 (en) 1979-09-21

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