FR2322152A1 - Epoxy alkyl phosphonic acid derivs - antibacterials by reduction and epoxidation of an alkynyl phosphonate - Google Patents

Epoxy alkyl phosphonic acid derivs - antibacterials by reduction and epoxidation of an alkynyl phosphonate

Info

Publication number
FR2322152A1
FR2322152A1 FR7532920A FR7532920A FR2322152A1 FR 2322152 A1 FR2322152 A1 FR 2322152A1 FR 7532920 A FR7532920 A FR 7532920A FR 7532920 A FR7532920 A FR 7532920A FR 2322152 A1 FR2322152 A1 FR 2322152A1
Authority
FR
France
Prior art keywords
epoxidation
antibacterials
reduction
phosphonate
phosphonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7532920A
Other languages
French (fr)
Other versions
FR2322152B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ITALCHEMI ISTITUTO CHIMICO FAR
Original Assignee
ITALCHEMI ISTITUTO CHIMICO FAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ITALCHEMI ISTITUTO CHIMICO FAR filed Critical ITALCHEMI ISTITUTO CHIMICO FAR
Publication of FR2322152A1 publication Critical patent/FR2322152A1/en
Application granted granted Critical
Publication of FR2322152B1 publication Critical patent/FR2322152B1/en
Expired legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505Phosphonic acids containing oxirane groups; esters thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/625Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Epoxyalkyl phosphonic acids of formula (I)RCHCH-P(O) (OR')2 and their salts with alkali(ne earth(metals or amines, are prepd. by reacting a dialkyl chloroacetylene phosphonate Cl-C=CP( O)(OR') with a Grignard reagent to obtain R-C=C-P(=O)(OR') which is selective hydrogenated to a cis alkenyl phosphonate R-CH=CH-P(=O)(OR')2 which is then subjected to epoxidation to (I). (R and R' are each H or alkyl or R' is a salt forming radical or an optically active amine). (I) are antibacterial agents.
FR7532920A 1975-08-29 1975-10-28 PROCESS FOR PREPARING EPOXYALKYLPHOSPHONIC ACIDS Expired FR2322152B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2675675A IT1042192B (en) 1975-08-29 1975-08-29 SYNTHESIS OF SPHONIC EPOXIALKYLPHIC ACIDS

Publications (2)

Publication Number Publication Date
FR2322152A1 true FR2322152A1 (en) 1977-03-25
FR2322152B1 FR2322152B1 (en) 1978-06-30

Family

ID=11220177

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7532920A Expired FR2322152B1 (en) 1975-08-29 1975-10-28 PROCESS FOR PREPARING EPOXYALKYLPHOSPHONIC ACIDS

Country Status (4)

Country Link
JP (1) JPS5231032A (en)
BE (1) BE834591A (en)
FR (1) FR2322152B1 (en)
IT (1) IT1042192B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62207281A (en) * 1986-03-06 1987-09-11 Shizuoka Univ Production of alpha,beta-epoxyphosphine derivative
JP4654412B2 (en) * 2005-04-07 2011-03-23 独立行政法人産業技術総合研究所 Process for producing α-epoxyphosphonic acids
JP4524404B2 (en) * 2005-08-19 2010-08-18 独立行政法人産業技術総合研究所 Method for producing epoxy group-containing phosphorus compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2011837A1 (en) * 1968-05-15 1970-03-13 Merck & Co Inc

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2011837A1 (en) * 1968-05-15 1970-03-13 Merck & Co Inc

Also Published As

Publication number Publication date
JPS5231032A (en) 1977-03-09
BE834591A (en) 1976-02-16
FR2322152B1 (en) 1978-06-30
IT1042192B (en) 1980-01-30

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