FR2321298A1 - Compsns. with species-specific interferon activity - prepd. by incubating the appropriate messenger RNA in a cell-free medium - Google Patents

Compsns. with species-specific interferon activity - prepd. by incubating the appropriate messenger RNA in a cell-free medium

Info

Publication number
FR2321298A1
FR2321298A1 FR7524150A FR7524150A FR2321298A1 FR 2321298 A1 FR2321298 A1 FR 2321298A1 FR 7524150 A FR7524150 A FR 7524150A FR 7524150 A FR7524150 A FR 7524150A FR 2321298 A1 FR2321298 A1 FR 2321298A1
Authority
FR
France
Prior art keywords
compsns
prepd
incubating
species
messenger rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7524150A
Other languages
French (fr)
Other versions
FR2321298B1 (en
Inventor
Minh-Nguy Thang
Edward De Maeyer
Luc Montagnier
Diec Chi Thang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7524150A priority Critical patent/FR2321298A1/en
Publication of FR2321298A1 publication Critical patent/FR2321298A1/en
Application granted granted Critical
Publication of FR2321298B1 publication Critical patent/FR2321298B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A therapeutic compsn. is prepd. by incubating a medium contg. messenger RNA (I); an accelular extract contg. components necessary for protein synthesis obtd. from human, animal, vegetable or bacterial cells and a buffer to maintain pH 6-9. The medium also contains (pref. ranges) stabilising monovalent (50-100 mM) and divalent (1-5 mM) ions; a reducing agent (ii; 1-5 mM); a polyamine (III; 0.1-0.3 mM); a mixture of the 20 natural amino acids (20-50 mu M); ATP (0.5-2 mM); GTP (10-50 mu M) and products (V) which generate nucleoside triphosphates (5-15 mM). incubation is at 10-40 degrees C, esp. about ambient. USe/ ADVANTAGE : ADVANTAGES The compsns. have interferon activity (formed by 'translation' of (I) and hence specific for the species from which (I) is derived), and any type of interferon can be produced in high yield. They are useful as antivirals, immunodepressants and to prevent development of metastases in cancerous states esp. in sarcoma of the bone.
FR7524150A 1975-08-01 1975-08-01 Compsns. with species-specific interferon activity - prepd. by incubating the appropriate messenger RNA in a cell-free medium Granted FR2321298A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7524150A FR2321298A1 (en) 1975-08-01 1975-08-01 Compsns. with species-specific interferon activity - prepd. by incubating the appropriate messenger RNA in a cell-free medium

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7524150A FR2321298A1 (en) 1975-08-01 1975-08-01 Compsns. with species-specific interferon activity - prepd. by incubating the appropriate messenger RNA in a cell-free medium

Publications (2)

Publication Number Publication Date
FR2321298A1 true FR2321298A1 (en) 1977-03-18
FR2321298B1 FR2321298B1 (en) 1982-07-16

Family

ID=9158685

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7524150A Granted FR2321298A1 (en) 1975-08-01 1975-08-01 Compsns. with species-specific interferon activity - prepd. by incubating the appropriate messenger RNA in a cell-free medium

Country Status (1)

Country Link
FR (1) FR2321298A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2475901A1 (en) * 1979-11-21 1981-08-21 Yeda Res & Dev INTERFERON PRODUCTION PROCESS
EP0041313A2 (en) * 1980-04-03 1981-12-09 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2475901A1 (en) * 1979-11-21 1981-08-21 Yeda Res & Dev INTERFERON PRODUCTION PROCESS
EP0041313A2 (en) * 1980-04-03 1981-12-09 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon
EP0041313A3 (en) * 1980-04-03 1982-08-18 Biogen N.V. Dna sequences, recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides
US7588755B1 (en) 1980-04-03 2009-09-15 Biogen Idec Ma Inc. DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon-like polypeptides

Also Published As

Publication number Publication date
FR2321298B1 (en) 1982-07-16

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