FR2320737A1 - Magnesium aryloxyalkanoate prodn for medical uses - by reacting metallic magnesium with aryloxyalkanoic acid in solvent - Google Patents
Magnesium aryloxyalkanoate prodn for medical uses - by reacting metallic magnesium with aryloxyalkanoic acid in solventInfo
- Publication number
- FR2320737A1 FR2320737A1 FR7512987A FR7512987A FR2320737A1 FR 2320737 A1 FR2320737 A1 FR 2320737A1 FR 7512987 A FR7512987 A FR 7512987A FR 7512987 A FR7512987 A FR 7512987A FR 2320737 A1 FR2320737 A1 FR 2320737A1
- Authority
- FR
- France
- Prior art keywords
- salts
- magnesium
- solvent
- acids
- aryloxyalkanoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title abstract 5
- 239000002904 solvent Substances 0.000 title abstract 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title 2
- 229910052749 magnesium Inorganic materials 0.000 title 2
- 239000011777 magnesium Substances 0.000 title 2
- 150000003839 salts Chemical class 0.000 abstract 5
- 150000007513 acids Chemical class 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010001497 Agitation Diseases 0.000 abstract 1
- 241000208011 Digitalis Species 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 108010062497 VLDL Lipoproteins Proteins 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 125000003473 lipid group Chemical group 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Mg salts of aryloxyalkanoc acids of formula (in which R1 is H, CL, Br or F; R2 is 1-3C alkyl; R3 is 1-3C alkyl) are prepd. by reacting metallic Mg with the corresp. acid in a solvent, pref. at 50-100 deg C. The resulting salts can be dehydrated at 90-150 deg C. These salts are used in medicine to diminish the formation of triglycinde-rich, very-low-density lipoproteins, tissue lipides and steroids (Mg salts are superior in this respect to esters of these acids which are susceptible to esterase). Mg activates enzymes in the main synthesis of aftty acids; diminishes the excitability of myocardium and reduces the toxicity of digitalis, and suppresses the formation of cholestin and accumulation of Ca in blood vessels walls. The use of metallic Mg instead of Mg salts employed in conventional processes simplifies the procedures as impurities are not introduced and pure Mg aryloxyalkanoates are obtd.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT390174A AT346310B (en) | 1974-05-10 | 1974-05-10 | PROCESS FOR THE PRODUCTION OF MAGNESIUM SALT FROM PHENOXYALCANIC ACIDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2320737A1 true FR2320737A1 (en) | 1977-03-11 |
| FR2320737B1 FR2320737B1 (en) | 1979-06-08 |
Family
ID=3556974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7512987A Granted FR2320737A1 (en) | 1974-05-10 | 1975-04-25 | Magnesium aryloxyalkanoate prodn for medical uses - by reacting metallic magnesium with aryloxyalkanoic acid in solvent |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT346310B (en) |
| DE (1) | DE2520262A1 (en) |
| FR (1) | FR2320737A1 (en) |
| IT (1) | IT1044286B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT346313B (en) * | 1976-10-18 | 1978-11-10 | Hauser Chepharin Paul | PROCESS FOR THE PREPARATION OF THE MAGNESIUM SALT OF P-CHLOROPHENOXYISOBUTTER ACID |
| DE4446387A1 (en) * | 1994-12-23 | 1996-06-27 | Basf Ag | Process for the preparation of solid, free-flowing water-soluble salts of aryloxi-C¶1¶-C¶4¶-alkane carboxylic acids |
-
1974
- 1974-05-10 AT AT390174A patent/AT346310B/en not_active IP Right Cessation
-
1975
- 1975-04-25 FR FR7512987A patent/FR2320737A1/en active Granted
- 1975-05-07 DE DE19752520262 patent/DE2520262A1/en active Pending
- 1975-05-09 IT IT2314275A patent/IT1044286B/en active
Non-Patent Citations (1)
| Title |
|---|
| NEANT * |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA390174A (en) | 1976-01-15 |
| AT346310B (en) | 1978-11-10 |
| IT1044286B (en) | 1980-03-20 |
| DE2520262A1 (en) | 1975-11-20 |
| FR2320737B1 (en) | 1979-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |