FR22C1036I1 - PYRIMIDINE DERIVATIVES AS HIV INHIBITOR - Google Patents

PYRIMIDINE DERIVATIVES AS HIV INHIBITOR

Info

Publication number
FR22C1036I1
FR22C1036I1 FR22C1036C FR22C1036C FR22C1036I1 FR 22C1036 I1 FR22C1036 I1 FR 22C1036I1 FR 22C1036 C FR22C1036 C FR 22C1036C FR 22C1036 C FR22C1036 C FR 22C1036C FR 22C1036 I1 FR22C1036 I1 FR 22C1036I1
Authority
FR
France
Prior art keywords
pyrimidine derivatives
hiv inhibitor
hiv
inhibitor
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1036C
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26076978&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR22C1036(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of FR22C1036I1 publication Critical patent/FR22C1036I1/en
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/12—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR22C1036C 2001-08-13 2022-07-27 PYRIMIDINE DERIVATIVES AS HIV INHIBITOR Active FR22C1036I1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP01203090 2001-08-13
EP02077748 2002-06-10
EP02764839A EP1419152B1 (en) 2001-08-13 2002-08-09 Hiv inhibiting pyrimidines derivatives
PCT/EP2002/008953 WO2003016306A1 (en) 2001-08-13 2002-08-09 Hiv inhibiting pyrimidines derivatives
EP10178189.6A EP2298761B1 (en) 2001-08-13 2002-08-09 Hiv inhibiting pyrimidines derivatives

Publications (1)

Publication Number Publication Date
FR22C1036I1 true FR22C1036I1 (en) 2022-09-09

Family

ID=26076978

Family Applications (3)

Application Number Title Priority Date Filing Date
FR12C0035C Active FR12C0035I2 (en) 2001-08-13 2012-05-22 PYRIMIDINE DERIVATIVES HIV INHIBITORS
FR12C0036C Active FR12C0036I2 (en) 2001-08-13 2012-05-25 PYRIMIDINE DERIVATIVES HIV INHIBITORS
FR22C1036C Active FR22C1036I1 (en) 2001-08-13 2022-07-27 PYRIMIDINE DERIVATIVES AS HIV INHIBITOR

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FR12C0035C Active FR12C0035I2 (en) 2001-08-13 2012-05-22 PYRIMIDINE DERIVATIVES HIV INHIBITORS
FR12C0036C Active FR12C0036I2 (en) 2001-08-13 2012-05-25 PYRIMIDINE DERIVATIVES HIV INHIBITORS

Country Status (37)

Country Link
US (8) US7125879B2 (en)
EP (3) EP3808743B1 (en)
JP (4) JP2005507380A (en)
KR (2) KR100969273B1 (en)
CN (2) CN100509801C (en)
AP (1) AP1610A (en)
AR (1) AR036387A1 (en)
AT (1) ATE517891T1 (en)
AU (1) AU2002329238C1 (en)
BE (3) BE2012C020I2 (en)
BR (3) BRPI0211909B8 (en)
CA (1) CA2452217C (en)
CY (4) CY1112331T1 (en)
DE (1) DE122012000038I1 (en)
DK (2) DK3808743T3 (en)
EA (1) EA006656B1 (en)
EG (1) EG24684A (en)
ES (3) ES2923581T3 (en)
FR (3) FR12C0035I2 (en)
HR (3) HRP20040096B1 (en)
HU (5) HU231274B1 (en)
IL (2) IL160328A0 (en)
JO (1) JO3429B1 (en)
LT (3) LT3808743T (en)
LU (2) LU92001I2 (en)
MX (1) MXPA04001401A (en)
MY (1) MY189572A (en)
NO (3) NO327639B1 (en)
NZ (1) NZ530951A (en)
OA (1) OA12652A (en)
PA (1) PA8552901A1 (en)
PL (2) PL216398B1 (en)
PT (1) PT1419152E (en)
SI (2) SI1419152T1 (en)
UA (1) UA78221C2 (en)
WO (1) WO2003016306A1 (en)
ZA (1) ZA200401159B (en)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638522B2 (en) * 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
MY169670A (en) * 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
US8101629B2 (en) * 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
JO3429B1 (en) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv Hiv inhibiting pyrimidines derivatives
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
BR0307624A (en) 2002-03-13 2005-01-11 Janssen Pharmaceutica Nv Histone Deacetylase Inhibitors
AR039540A1 (en) 2002-05-13 2005-02-23 Tibotec Pharm Ltd MICROBICIDE COMPOUNDS WITH PIRIMIDINE OR TRIAZINE CONTENT
ES2445208T3 (en) 2002-07-29 2014-02-28 Rigel Pharmaceuticals, Inc. 2,4-Pyrimidinediamine compounds for use in methods to treat or prevent autoimmune diseases
KR101140785B1 (en) * 2002-08-09 2012-05-03 얀센 파마슈티카 엔.브이. Processes for the preparation of 4-[[4-[[4-2-cyanoethenyl-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
KR20050084027A (en) * 2002-11-28 2005-08-26 쉐링 악티엔게젤샤프트 Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
HRP20050688B1 (en) * 2003-02-07 2017-03-24 Janssen Pharmaceutica N.V. PYRIMIDINE DERIVATIVES TO PREVENT HIV INFECTION
JP4783725B2 (en) * 2003-02-07 2011-09-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 1,2,4-triazine that inhibits HIV
CL2004000303A1 (en) 2003-02-20 2005-04-08 Tibotec Pharm Ltd COMPOUNDS DERIVED FROM PYRIMIDINS AND TRIAZINES; PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION; AND ITS USE TO INHIBIT HIV REPLICATION.
EP1648467B1 (en) 2003-07-17 2018-03-21 Janssen Sciences Ireland UC Process for preparing particles containing an antiviral
AU2004265288A1 (en) 2003-07-30 2005-02-24 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
CA2533320A1 (en) * 2003-08-15 2006-02-24 Novartis Ag 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
TWI365744B (en) * 2003-09-03 2012-06-11 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
EA009734B1 (en) 2003-09-25 2008-02-28 Янссен Фармацевтика Н.В. Hiv replication inhibiting purine derivatives
NZ588139A (en) 2004-04-08 2012-02-24 Targegen Inc 7-Aryl-3-arylamino-benzo[1,2,4]triazine derivatives
NZ552865A (en) 2004-07-28 2009-09-25 Janssen Pharmaceutica Nv Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
AU2005271161B2 (en) 2004-08-10 2011-05-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
PL2135608T3 (en) 2004-08-25 2012-07-31 Ardea Biosciences Inc S-triazolyl alpha -mercaptoacetanilides as inhibitors of HIV reverse transcriptase
WO2007050087A1 (en) 2004-08-25 2007-05-03 Ardea Biosciences, Inc. N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS
MX2007002594A (en) * 2004-09-02 2007-04-25 Janssen Pharmaceutica Nv Furamate of 4-( (4-( (4- (2-cyanoethenyl) -2, 6-dimethylphenyl) amino)-2 -pyrimidinyl) amino)benzonitrile.
AU2005279158C1 (en) * 2004-09-02 2010-12-16 Janssen Pharmaceutica N.V. Hydrochloride of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl] amino]benzonitrile
SG155885A1 (en) * 2004-09-02 2009-10-29 Janssen Pharmaceutica Nv Furamate of 4-((4-((4-(2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2- pyrimidinyl)amino)benzonitrile
PT1632232E (en) * 2004-09-02 2011-08-02 Janssen Pharmaceutica Nv 4 - [[4 - [[4- (2-CYANOOETHENYL) -2,6-DIMETHYLPHENYL] AMINO] -2-PYRIMIDINYL] AMINO] BENZONITRYL
KR101276571B1 (en) 2004-09-02 2013-06-18 얀센 파마슈티카 엔.브이. Furamate of 4-((4-(4-(2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile
EP1799667B1 (en) 2004-09-20 2013-03-20 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
JP2008513515A (en) 2004-09-20 2008-05-01 ゼノン・ファーマシューティカルズ・インコーポレイテッド Heterocyclic derivatives and their use as therapeutic agents
TW200626155A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
WO2006034440A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
WO2006034315A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
CN101083993A (en) 2004-09-20 2007-12-05 泽农医药公司 Heterocyclic derivatives and their use as therapeutic agents
CN101084212A (en) 2004-09-20 2007-12-05 泽农医药公司 Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
US8575342B2 (en) 2004-09-30 2013-11-05 Tibotech Pharmaceuticals Ltd. HIV inhibiting 5-heterocyclyl pyrimidines
WO2006035068A2 (en) * 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines
RU2410379C2 (en) * 2004-09-30 2011-01-27 Тиботек Фармасьютикалз Лтд. 5-substituted hiv-inhibiting pyrimidines
JP5095409B2 (en) 2004-11-24 2012-12-12 ライジェル ファーマシューティカルズ， インコーポレイテッド Spiro 2,4-pyrimidinediamine compounds and uses thereof
PT1856135E (en) 2005-01-19 2010-02-26 Rigel Pharmaceuticals Inc Prodrugs of 2,4-pyrimidinediamine compounds and their uses
ES2548729T3 (en) 2005-03-31 2015-10-20 Santen Pharmaceutical Co., Ltd. New cyclic compound having pyrimidinylalkylthio group
TWI457136B (en) 2005-04-04 2014-10-21 Tibotec Pharm Ltd Prevention of hiv-infection
ATE541848T1 (en) 2005-05-05 2012-02-15 Ardea Biosciences Inc DIARYL-PURINE, AZAPURINE AND DEAZAPURINE AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF HIV
RS53062B (en) * 2005-05-26 2014-04-30 Janssen R&D Ireland PREPARATION PROCESS 4 - [(1,6-Dihydro-6-oxo-2-pyrimidinyl) AMINO BENZONITRILA
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP1904457B1 (en) 2005-06-08 2017-09-06 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
BR122021011787B1 (en) 2005-11-01 2022-01-25 Impact Biomedicines, Inc Biaryl metapyrimidine kinase inhibitors, pharmaceutical composition and process for preparing a pharmaceutical composition
WO2007082874A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
PT1981506E (en) 2006-01-20 2013-06-25 Janssen R & D Ireland Long term treatment of hiv- infection with tcm278
WO2007113254A1 (en) 2006-03-30 2007-10-11 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-amido substituted pyrimidines
US8163745B2 (en) 2006-03-30 2012-04-24 Tibotec Pharmaceuticals Ltd. HIV inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines
KR101406879B1 (en) * 2006-06-23 2014-06-13 얀센 알 앤드 디 아일랜드 Aqueous suspension of TMC278
AU2016219555B2 (en) * 2006-06-23 2017-08-10 Janssen Sciences Ireland Uc Aqueous suspensions of TMC278
AU2014200819B2 (en) * 2006-06-23 2016-05-26 Janssen Sciences Ireland Uc Aqueous suspensions of TMC278
US7595324B2 (en) 2006-11-09 2009-09-29 Ardea Biosciences, Inc. Substituted thieno[3,2-D]pyrimidines as HIV inhibitors
ES2524009T3 (en) 2006-12-08 2014-12-03 Irm Llc Compounds and compositions as protein kinase inhibitors
JP5415957B2 (en) 2006-12-13 2014-02-12 エフ．ホフマン−ラ ロシュ アーゲー 2- (Piperidin-4-yl) -4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors
JP5185283B2 (en) 2006-12-29 2013-04-17 テイボテク・フアーマシユーチカルズ HIV inhibitory 6-substituted pyrimidines
EP2781510B1 (en) 2006-12-29 2016-12-14 Janssen Sciences Ireland UC Hiv inhibiting 5,6-substituted pyrimidines
EP2121613A2 (en) 2007-01-31 2009-11-25 Vertex Pharmaceuticals, Inc. 2-aminopyridine derivatives useful as kinase inhibitors
TWI494133B (en) * 2007-03-14 2015-08-01 Tibotec Pharm Ltd Powders for reconstitution
KR101132880B1 (en) * 2007-04-18 2012-06-28 화이자 프로덕츠 인크. Sulfonyl amide derivatives for the treatment of abnormal cell growth
KR101542629B1 (en) 2007-05-30 2015-08-06 에프. 호프만-라 로슈 아게 - non-nucleoside reverse transcriptase inhibitors
KR101294731B1 (en) * 2007-06-04 2013-08-16 삼성디스플레이 주식회사 Array substrate, display panel having the array substrate and method of manufacturing the array substrate
EP2175857B1 (en) 2007-07-12 2013-09-11 Janssen R&D Ireland Crystalline form of (e) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
CN101407476B (en) * 2007-10-12 2012-07-18 中国人民解放军军事医学科学院毒物药物研究所 M-bis(arene) polysubstituted aniline compound as non-nucleoside HIV reverse transcriptase inhibitor, and preparation and use thereof
WO2009070740A2 (en) 2007-11-27 2009-06-04 Ardea Biosciences Inc. Novel compounds and compositions and methods of use
EP2220091B1 (en) 2007-12-14 2012-07-25 Ardea Biosciences, Inc. Reverse transcriptase inhibitors
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
EP3549934A1 (en) 2008-06-27 2019-10-09 Celgene CAR LLC Heteroaryl compounds and uses thereof
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
CA2731451A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
CN102131809A (en) 2008-07-23 2011-07-20 沃泰克斯药物股份有限公司 Tri-cyclic pyrazolopyridine kinase inhibitors
MX2011001319A (en) 2008-08-06 2011-04-05 Vertex Pharma Aminopyridine kinase inhibitors.
WO2010040275A1 (en) * 2008-10-09 2010-04-15 中国人民解放军军事医学科学院毒物药物研究所 The 2-(4-substituted phenylamino) polysubstituted pyridine compounds as the inhibitors of non-nucleoside hiv reverse transcriptase, praparation methods and uses thereof
CN101717364B (en) * 2008-10-09 2014-08-13 中国人民解放军军事医学科学院毒物药物研究所 Paradoximes as HIV reverse transcriptase inhibitor as well as preparation method and purpose thereof
EP2181991A1 (en) 2008-10-28 2010-05-05 LEK Pharmaceuticals D.D. Novel salts of sunitinib
EP2186809A1 (en) * 2008-11-13 2010-05-19 LEK Pharmaceuticals D.D. New crystal form of sunitinib malate
WO2010072844A1 (en) 2008-12-24 2010-07-01 Tibotec Pharmaceuticals Implantable devices for treating hiv
EP2440559B1 (en) 2009-05-05 2018-01-10 Dana-Farber Cancer Institute, Inc. Egfr inhibitors and methods of treating disorders
CA2760705A1 (en) 2009-05-06 2010-11-11 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
WO2011094290A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
CA2787315A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
DK2531027T3 (en) 2010-01-27 2015-07-20 Viiv Healthcare Co A therapeutic combination comprising dolutegravir, abacavir and lamivudine,
CA2787079A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
WO2011103457A1 (en) 2010-02-18 2011-08-25 Concert Pharmaceuticals Inc. Pyrimidine derivatives
US8367315B2 (en) 2010-03-05 2013-02-05 Adan Rios Inactivation of reverse transcriptases by azido-diarylpyrimidines
NZ607845A (en) 2010-08-10 2015-03-27 Celgene Avilomics Res Inc Besylate salt of a btk inhibitor
US9238629B2 (en) 2010-11-01 2016-01-19 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
CA2815858C (en) 2010-11-01 2018-10-16 Celgene Avilomics Research, Inc. Heterocyclic compounds and uses thereof
AU2010363329A1 (en) 2010-11-07 2013-05-09 Targegen, Inc. Compositions and methods for treating myelofibrosis
EP2637502B1 (en) 2010-11-10 2018-01-10 Celgene CAR LLC Mutant-selective egfr inhibitors and uses thereof
TWI556840B (en) 2010-11-19 2016-11-11 吉李德科學股份有限公司 Therapeutic compositions
WO2012125993A1 (en) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Solid state forms of rilpivirine base, and rilipivirine salts
CA2834257C (en) 2011-04-25 2019-03-12 Hetero Research Foundation Process for rilpivirine
HUE034802T2 (en) 2011-08-30 2018-02-28 Chdi Foundation Inc Kinurenin-3-monooxygenase inhibitors, pharmaceutical preparations and methods of use
ES2680146T3 (en) 2011-09-16 2018-09-04 Hetero Research Foundation Rilpivirine Hydrochloride
WO2013063401A1 (en) 2011-10-28 2013-05-02 Celgene Avilomics Research, Inc. Methods of treating a bruton's tyrosine kinase disease or disorder
EP2604593A1 (en) 2011-12-14 2013-06-19 Sandoz AG Polymorph of Rilpivirine hydrochloride and its use as antiviral
WO2013087794A1 (en) 2011-12-14 2013-06-20 Sandoz Ag Polymorph of rilpivirine hydrochloride and its use as antiviral
EP2628732A1 (en) 2012-02-20 2013-08-21 Sandoz AG Novel crystalline form of rilpivirine hydrochloride
RS57901B1 (en) 2012-03-15 2019-01-31 Celgene Car Llc Salts of an epidermal growth factor receptor kinase inhibitor
SG11201405691WA (en) 2012-03-15 2014-10-30 Celgene Avilomics Res Inc Solid forms of an epidermal growth factor receptor kinase inhibitor
WO2013153161A2 (en) 2012-04-11 2013-10-17 Sandoz Ag Novel polymorph of rilpivirine hydrochloride
WO2013153162A1 (en) 2012-04-11 2013-10-17 Sandoz Ag Polymorph of rilpivirine hydrochloride
WO2013179105A1 (en) * 2012-06-01 2013-12-05 Laurus Labs Private Limited Improved process for preparation of rilpivirine and pharmaceutically acceptable salts thereof
WO2014009968A2 (en) * 2012-07-12 2014-01-16 Hetero Research Foundation Process for rilpivirine using novel intermediate
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
US9126950B2 (en) 2012-12-21 2015-09-08 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP2953457B1 (en) 2013-02-08 2020-04-08 Celgene CAR LLC Erk inhibitors and uses thereof
US9914709B2 (en) 2013-06-21 2018-03-13 Yale University Compositions and methods of treating HIV-1 infections using same
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
CA2955379C (en) * 2014-07-17 2022-12-13 Chdi Foundation, Inc. Methods and compositions for treating hiv-related disorders
WO2016025561A1 (en) 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor
CR20170113A (en) 2014-09-26 2017-05-26 Glaxosmilthkline Intellectual Property (No 2) Ltd PHARMACEUTICAL COMPOSITIONS OF PROLONGED ACTION
CZ201532A3 (en) 2015-01-21 2015-02-25 Zentiva, K.S. Process for preparing extremely pure rilpivirine and salt thereof
CN104926829A (en) * 2015-06-08 2015-09-23 山东大学 Thieno miazines derivatives and preparation method and application thereof
BR112017027843A2 (en) 2015-06-30 2018-09-04 Gilead Sciences, Inc. pharmaceutical formulations comprising tenofovir and emtricitabine
CZ2015579A3 (en) 2015-08-27 2017-03-08 Zentiva, K.S. The crystalline form of A rilpivirine adipate and method of its preparation
CN106187916B (en) * 2016-07-04 2018-08-21 宜昌人福药业有限责任公司 A method of effectively removing rilpivirine isomers
FI3528791T3 (en) 2016-10-24 2024-01-30 Janssen Sciences Ireland Unlimited Co Dispersible compositions
CN106749203B (en) * 2016-11-28 2020-04-10 洛阳聚慧医药科技有限公司 Pyrimidine heterocyclic compound, pyrimidine heterocyclic compound salt, preparation method and application
CN106588696B (en) * 2016-12-08 2018-12-25 西北师范大学 A kind of preparation method of trans- 'alpha ', ' bela '-unsaturated nitrile class compound
CN106905244B (en) * 2017-02-27 2019-08-16 武汉工程大学 Diaryl pyrimidine-diketone acid heterozygous HIV-1 inhibitor and preparation method thereof
KR102722927B1 (en) 2017-06-30 2024-10-28 비이브 헬쓰케어 컴퍼니 Combinations and their uses and treatments
ES3036496T3 (en) 2018-09-18 2025-09-19 Nikang Therapeutics Inc Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
CN109293581B (en) * 2018-09-21 2020-03-27 宜昌人福药业有限责任公司 A kind of method for preparing rilpivirine hydrochloride isomer Z and impurity X and the application of impurity X in agriculture as pesticide
US20210380540A1 (en) 2018-10-25 2021-12-09 Minakem Process for the preparation of rilpivirine
AU2020300818A1 (en) * 2019-07-03 2022-03-03 Janssen Sciences Ireland Unlimited Company Methods of treating HIV in pediatric patients with rilpivirine
CN110526873B (en) * 2019-08-15 2022-09-16 复旦大学 Cyanovinyl substituted benzodiarylpyrimidine compound and preparation method and application thereof
WO2021104487A1 (en) 2019-11-29 2021-06-03 Aptorum Therapeutics Limited Composition including rilpivirine and use thereof for treating tumors or cancer
CN111004215B (en) * 2019-12-22 2022-08-09 华北理工大学 2, 4-substituted pyrimidine derivatives, preparation method thereof and application thereof in preparing antitumor drugs
CN111217833B (en) * 2020-02-21 2021-03-16 山东大学 Thieno [2,3-d ] pyrimidine HIV-1 non-nucleoside reverse transcriptase inhibitor and preparation method and application thereof
WO2022000019A1 (en) * 2020-06-30 2022-01-06 University Of South Australia New therapeutic use of rilpivirine
CN112010810B (en) * 2020-09-09 2024-01-30 瑞阳制药股份有限公司 Method for preparing high-purity rilpivirine intermediate by one-pot method
CN112028836B (en) * 2020-09-09 2021-12-07 山东大学 Diarylpyrimidine derivative containing six-membered nitrogen heterocycle and preparation method and application thereof
WO2022079739A1 (en) 2020-10-14 2022-04-21 Cipla Limited Fixed dose compositions of cabotegravir and rilpivirine
TW202233192A (en) 2020-11-17 2022-09-01 愛爾蘭商健生科學愛爾蘭無限公司 Treatment or prevention of hiv infection
CN112546969B (en) * 2020-12-07 2022-12-23 安徽贝克制药股份有限公司 Catalytic hydrogenation continuous production device and preparation method of ritonavir intermediate
CN112778214A (en) * 2021-01-13 2021-05-11 安徽贝克联合制药有限公司 Intermediate for synthesizing rilpivirine, synthesis method thereof and rilpivirine synthesis method
CN113105394A (en) * 2021-03-08 2021-07-13 复旦大学 Biphenyl diaryl pyrimidine derivative containing aromatic heterocyclic structure and preparation method and application thereof
CN113461666A (en) * 2021-05-06 2021-10-01 复旦大学 Biphenyl diaryl methyl pyrimidine derivative containing aromatic heterocyclic structure and preparation method thereof
CN113845515A (en) * 2021-09-03 2021-12-28 复旦大学 Aromatic heterocyclic structure-containing dimethyl biphenyl diaryl pyrimidine derivative and preparation method and application thereof
CA3234763A1 (en) 2021-11-17 2023-05-25 Janssen Sciences Ireland Unlimited Company Dissolution test
US20250268896A1 (en) 2022-04-22 2025-08-28 Janssen Sciences Ireland Unlimited Company Liquid compositions
TW202406551A (en) 2022-04-22 2024-02-16 愛爾蘭商健生科學愛爾蘭無限公司 Freeze dried compositions
TW202408526A (en) 2022-05-17 2024-03-01 愛爾蘭商健生科學愛爾蘭無限公司 Treatment or prevention of hiv infection
TW202408527A (en) 2022-05-17 2024-03-01 愛爾蘭商健生科學愛爾蘭無限公司 Treatment or prevention of hiv infection
CN115490642B (en) * 2022-09-21 2024-11-15 山东大学 A diaryl pyrimidine compound containing an ether bond and its preparation method and application

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
US3953398A (en) * 1970-07-20 1976-04-27 The Goodyear Tire & Rubber Company Age resistant polymeric compositions
JPS63159316A (en) * 1977-11-28 1988-07-02 アルキユサル　インコーポレーテツド　ピーテイワイ　リミテツド Antiinflammatory composition containing neutral copper bonded body
JPS5490121A (en) * 1977-11-28 1979-07-17 Boettcher Barry Neutral copper bonded body and antiinflaming agent
JPS5879920A (en) * 1981-11-09 1983-05-13 Kanegafuchi Chem Ind Co Ltd Inhibitor against blood platelet aggregation
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5691364A (en) 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
CN1198655C (en) 1995-11-23 2005-04-27 詹森药业有限公司 Solid mixtures of cyclodextrins prepd. via melt-extrusion
TW429256B (en) 1995-12-27 2001-04-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
JP3990808B2 (en) * 1998-03-26 2007-10-17 Ｔｄｋ株式会社 Method for producing electrode for non-aqueous electrolyte battery
EP0945447A1 (en) * 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections
KR100643419B1 (en) * 1998-03-27 2006-11-10 얀센 파마슈티카 엔.브이. Pyrimidine Derivatives That Inhibit HIV
PT945443E (en) 1998-03-27 2003-06-30 Janssen Pharmaceutica Nv HIV INHIBITOR PYRIMIDINE DERIVATIVES
JP2000035628A (en) * 1998-07-16 2000-02-02 Konica Corp Silver halide photographic sensitive material
JP2002523497A (en) * 1998-08-29 2002-07-30 アストラゼネカ・アクチエボラーグ Pyrimidine compounds
CZ301367B6 (en) 1998-11-10 2010-02-03 Janssen Pharmaceutica N. V. Pyrimidine derivative, process and intermediates for its preparation and medicament based thereon and intended for treating HIV
US6239142B1 (en) 1999-03-09 2001-05-29 Pharmacia & Upjohn Company 4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5carboxamides as antiviral agents
ES2391550T3 (en) 1999-04-15 2012-11-27 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
TR200200763T2 (en) * 1999-09-24 2003-09-22 Janssen Pharmaceutica N.V. Antiviral compositions
DE19945982A1 (en) 1999-09-24 2001-03-29 Knoll Ag Velocity-determined particles
KR20030024659A (en) 2000-02-17 2003-03-26 암겐 인코포레이티드 Kinase Inhibitors
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004887D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
ES2542326T3 (en) 2000-05-08 2015-08-04 Janssen Pharmaceutica Nv HIV replication inhibitors
US7034019B2 (en) 2000-05-08 2006-04-25 Janssen Pharmaceutica N.V. Prodrugs of HIV replication inhibiting pyrimidines
US6596729B2 (en) * 2000-07-20 2003-07-22 Bristol-Myers Squibb Company Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
MXPA03007883A (en) * 2001-03-02 2003-12-04 Smithkline Beecham Corp Benzophenones as inhibitors of reverse transcriptase.
DE60223790T4 (en) * 2001-03-29 2009-05-07 Vertex Pharmaceuticals Inc., Cambridge HEMMER OF C-JUN TERMINAL KINASE (JNK) AND OTHER PROTEIN KINASE
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
US8101629B2 (en) * 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
JO3429B1 (en) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv Hiv inhibiting pyrimidines derivatives
WO2003020210A2 (en) * 2001-08-29 2003-03-13 Umd, Inc. Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
KR20040111466A (en) * 2002-05-03 2004-12-31 얀센 파마슈티카 엔.브이. Polymeric microemulsions
KR101140785B1 (en) 2002-08-09 2012-05-03 얀센 파마슈티카 엔.브이. Processes for the preparation of 4-[[4-[[4-2-cyanoethenyl-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
AU2002350719A1 (en) * 2002-11-29 2004-06-23 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
HRP20050688B1 (en) 2003-02-07 2017-03-24 Janssen Pharmaceutica N.V. PYRIMIDINE DERIVATIVES TO PREVENT HIV INFECTION
WO2011103559A1 (en) * 2010-02-22 2011-08-25 Nektar Therapeutics Oligomer modified diaromatic substituted compounds

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