FR2293408A1 - Labelling of water soluble cpds. - with deuterium or tritium-by irradiation in presence of thiol - Google Patents

Labelling of water soluble cpds. - with deuterium or tritium-by irradiation in presence of thiol

Info

Publication number
FR2293408A1
FR2293408A1 FR7439686A FR7439686A FR2293408A1 FR 2293408 A1 FR2293408 A1 FR 2293408A1 FR 7439686 A FR7439686 A FR 7439686A FR 7439686 A FR7439686 A FR 7439686A FR 2293408 A1 FR2293408 A1 FR 2293408A1
Authority
FR
France
Prior art keywords
deuterium
labelled
water soluble
tritium
thiol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7439686A
Other languages
French (fr)
Other versions
FR2293408B1 (en
Inventor
Jean Cadet
Robert Teoule
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR7439686A priority Critical patent/FR2293408A1/en
Publication of FR2293408A1 publication Critical patent/FR2293408A1/en
Application granted granted Critical
Publication of FR2293408B1 publication Critical patent/FR2293408B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Abstract

Water soluble (organic) substances possessing simple bonds, or multiple bonds which are protectable, are isotopically labelled with deuterium or tritium by being irradiated in the absence of oxygen in deuterated or tritiated soln. contg. a water soluble mercaptan and then the labelled substance is separated. The process allows organic substances to be labelled which could not be labelled by prior art methods. The H of the thiol is replaced by deuterium. The iradiation creates radical sites on the substance to be labelled. The protons of these sites combine wih OH in the water and the S-D bonds are homolytically broken. The deuterium atoms are transferred to the radical sites.
FR7439686A 1974-12-04 1974-12-04 Labelling of water soluble cpds. - with deuterium or tritium-by irradiation in presence of thiol Granted FR2293408A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7439686A FR2293408A1 (en) 1974-12-04 1974-12-04 Labelling of water soluble cpds. - with deuterium or tritium-by irradiation in presence of thiol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7439686A FR2293408A1 (en) 1974-12-04 1974-12-04 Labelling of water soluble cpds. - with deuterium or tritium-by irradiation in presence of thiol

Publications (2)

Publication Number Publication Date
FR2293408A1 true FR2293408A1 (en) 1976-07-02
FR2293408B1 FR2293408B1 (en) 1977-03-25

Family

ID=9145547

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7439686A Granted FR2293408A1 (en) 1974-12-04 1974-12-04 Labelling of water soluble cpds. - with deuterium or tritium-by irradiation in presence of thiol

Country Status (1)

Country Link
FR (1) FR2293408A1 (en)

Also Published As

Publication number Publication date
FR2293408B1 (en) 1977-03-25

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Legal Events

Date Code Title Description
ST Notification of lapse