FR2265406A1 - Hepatitis B vaccine - contains Australian type serum hepatitis antigens in an immunogenic form, alumin and globulins - Google Patents
Hepatitis B vaccine - contains Australian type serum hepatitis antigens in an immunogenic form, alumin and globulinsInfo
- Publication number
- FR2265406A1 FR2265406A1 FR7509251A FR7509251A FR2265406A1 FR 2265406 A1 FR2265406 A1 FR 2265406A1 FR 7509251 A FR7509251 A FR 7509251A FR 7509251 A FR7509251 A FR 7509251A FR 2265406 A1 FR2265406 A1 FR 2265406A1
- Authority
- FR
- France
- Prior art keywords
- hepatitis
- vaccine
- globulins
- alumin
- australian type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 208000002672 hepatitis B Diseases 0.000 title abstract 2
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 title abstract 2
- 229940124736 hepatitis-B vaccine Drugs 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 102000006395 Globulins Human genes 0.000 title 1
- 108010044091 Globulins Proteins 0.000 title 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 title 1
- 210000002966 serum Anatomy 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 108010068307 Alpha-Globulins Proteins 0.000 abstract 1
- 108010087504 Beta-Globulins Proteins 0.000 abstract 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 abstract 1
- 108010074605 gamma-Globulins Proteins 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 229960000380 propiolactone Drugs 0.000 abstract 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Hepatitis B vaccine comprises a serum positive with respect to Australian type but non-infectious (i.e. not included by hepatitis) which contains, as well as albumin and alpha, beta and gamma-globulins, Australian type serum hepatitis antigens in an immunogenic form. The vaccine may be prepared by treatment of human serum mixed with beta-propiolactone (a) to exposure by ultraviolet irradiation and then (b) adsorption on colloidal silicic acid or (b) then (a) to ensure its inactivation and stability. The vaccine is used at a concentration of Australian type antigen of at least 0.1 mug/ml to ensure immunity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2415604A DE2415604A1 (en) | 1974-03-30 | 1974-03-30 | VACCINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2265406A1 true FR2265406A1 (en) | 1975-10-24 |
Family
ID=5911758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7509251A Pending FR2265406A1 (en) | 1974-03-30 | 1975-03-25 | Hepatitis B vaccine - contains Australian type serum hepatitis antigens in an immunogenic form, alumin and globulins |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE827145A (en) |
| DE (1) | DE2415604A1 (en) |
| DK (1) | DK110575A (en) |
| FR (1) | FR2265406A1 (en) |
| LU (1) | LU71976A1 (en) |
| NL (1) | NL7502660A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102858961A (en) * | 2010-05-03 | 2013-01-02 | 葛兰素史密丝克莱恩生物有限公司 | Novel method |
-
1974
- 1974-03-30 DE DE2415604A patent/DE2415604A1/en active Pending
-
1975
- 1975-03-06 LU LU71976A patent/LU71976A1/xx unknown
- 1975-03-06 NL NL7502660A patent/NL7502660A/en unknown
- 1975-03-18 DK DK110575A patent/DK110575A/da unknown
- 1975-03-25 BE BE154732A patent/BE827145A/en unknown
- 1975-03-25 FR FR7509251A patent/FR2265406A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL7502660A (en) | 1975-10-02 |
| DK110575A (en) | 1975-10-01 |
| LU71976A1 (en) | 1975-08-20 |
| BE827145A (en) | 1975-07-16 |
| DE2415604A1 (en) | 1975-10-02 |
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