FR2260576A1 - Cyclohexyl (3-thienyl) acetic acid prepn - by converting 2,5-dichlorothiophen into 3-glyoxylic acid, dehalogenating introducing cyclohexyl and reducing - Google Patents

Cyclohexyl (3-thienyl) acetic acid prepn - by converting 2,5-dichlorothiophen into 3-glyoxylic acid, dehalogenating introducing cyclohexyl and reducing

Info

Publication number
FR2260576A1
FR2260576A1 FR7404456A FR7404456A FR2260576A1 FR 2260576 A1 FR2260576 A1 FR 2260576A1 FR 7404456 A FR7404456 A FR 7404456A FR 7404456 A FR7404456 A FR 7404456A FR 2260576 A1 FR2260576 A1 FR 2260576A1
Authority
FR
France
Prior art keywords
cyclohexyl
thienyl
converting
dehalogenating
reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7404456A
Other languages
French (fr)
Other versions
FR2260576B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Innothera SAS
Original Assignee
Laboratoires Innothera SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Innothera SAS filed Critical Laboratoires Innothera SAS
Priority to FR7404456A priority Critical patent/FR2260576A1/en
Publication of FR2260576A1 publication Critical patent/FR2260576A1/en
Application granted granted Critical
Publication of FR2260576B1 publication Critical patent/FR2260576B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

alpha-Cyclohexyl-alpha-(3-thienyl)acetic acid is prepd. by converting 2,5-dicholorthiopehn into (2,5-dicholor-3-thienyl)-glyoxylic acid; dehalogenating to give 3-thienylgly-oxylic acid; converting into alpha-(3-thienyl)-alpha-cyclohexylgly-collic acid with an organometallic cpd; and reducing. The prods. are inters. for aminoalkyl esters, used in therapy.
FR7404456A 1974-02-11 1974-02-11 Cyclohexyl (3-thienyl) acetic acid prepn - by converting 2,5-dichlorothiophen into 3-glyoxylic acid, dehalogenating introducing cyclohexyl and reducing Granted FR2260576A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7404456A FR2260576A1 (en) 1974-02-11 1974-02-11 Cyclohexyl (3-thienyl) acetic acid prepn - by converting 2,5-dichlorothiophen into 3-glyoxylic acid, dehalogenating introducing cyclohexyl and reducing

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7404456A FR2260576A1 (en) 1974-02-11 1974-02-11 Cyclohexyl (3-thienyl) acetic acid prepn - by converting 2,5-dichlorothiophen into 3-glyoxylic acid, dehalogenating introducing cyclohexyl and reducing

Publications (2)

Publication Number Publication Date
FR2260576A1 true FR2260576A1 (en) 1975-09-05
FR2260576B1 FR2260576B1 (en) 1978-01-06

Family

ID=9134730

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7404456A Granted FR2260576A1 (en) 1974-02-11 1974-02-11 Cyclohexyl (3-thienyl) acetic acid prepn - by converting 2,5-dichlorothiophen into 3-glyoxylic acid, dehalogenating introducing cyclohexyl and reducing

Country Status (1)

Country Link
FR (1) FR2260576A1 (en)

Also Published As

Publication number Publication date
FR2260576B1 (en) 1978-01-06

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Legal Events

Date Code Title Description
ST Notification of lapse