FR2251330A1 - 2-aryl(alkyl)-5-hydrazinopyridazin-3-(2h)-ones - with cns depressant activity - Google Patents

2-aryl(alkyl)-5-hydrazinopyridazin-3-(2h)-ones - with cns depressant activity

Info

Publication number
FR2251330A1
FR2251330A1 FR7239439A FR7239439A FR2251330A1 FR 2251330 A1 FR2251330 A1 FR 2251330A1 FR 7239439 A FR7239439 A FR 7239439A FR 7239439 A FR7239439 A FR 7239439A FR 2251330 A1 FR2251330 A1 FR 2251330A1
Authority
FR
France
Prior art keywords
alkyl
hydrazinopyridazin
aryl
ones
depressant activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7239439A
Other languages
French (fr)
Other versions
FR2251330B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2251330A1 publication Critical patent/FR2251330A1/en
Application granted granted Critical
Publication of FR2251330B1 publication Critical patent/FR2251330B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cpds. of formula (I): (where R1 is H, 1-4C alkyl or 2-4C hydroxyalkyl (not alpha-hydroxyalkyl); R2 is H and R3 is H, 1-4C alkyl or 2-4C alkyl di-, tri- or tetrasubstd. by F or Cl, or NR2R3 is morpholino; R4 and R5 are H, F, Cl, Br, 1-4C alkyl or alkoxy, CF3 or NO2; X is H, F, Cl, or Br; n = 0,1 or 2; with the proviso that (a) >=1 of R1-R5 is other than H; (b) R1 is alkyl when R3 is alkyl; and (c) when R4 and R5 are independently CF3 or t-Bu, they are not no adjacent C atoms) are prepd. by reacting a cpd. (II): (where X' is Cl, F or Br) with R2R3N-NHR1. (I; X = H) are prepd. by catalytic hydrogenation of (I; X = Cl or Br). Cpds. (I) are mild tranquillisers, anticonvulsants and sedatives/hypnotics.
FR7239439A 1971-11-10 1972-11-08 2-aryl(alkyl)-5-hydrazinopyridazin-3-(2h)-ones - with cns depressant activity Granted FR2251330A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19740171A 1971-11-10 1971-11-10
US22726972A 1972-02-17 1972-02-17

Publications (2)

Publication Number Publication Date
FR2251330A1 true FR2251330A1 (en) 1975-06-13
FR2251330B1 FR2251330B1 (en) 1977-01-14

Family

ID=26892821

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7239439A Granted FR2251330A1 (en) 1971-11-10 1972-11-08 2-aryl(alkyl)-5-hydrazinopyridazin-3-(2h)-ones - with cns depressant activity

Country Status (8)

Country Link
JP (1) JPS4856690A (en)
AU (1) AU4870872A (en)
BE (1) BE791098A (en)
DD (1) DD101675A5 (en)
DE (1) DE2254564A1 (en)
FR (1) FR2251330A1 (en)
HU (1) HU164963B (en)
NL (1) NL7214879A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0102510A1 (en) * 1982-08-06 1984-03-14 BASF Aktiengesellschaft Substituted 4-fluoropyridaz-6-ones

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195645B (en) * 1985-10-30 1988-06-28 Gyogyszerkutato Intezet Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0102510A1 (en) * 1982-08-06 1984-03-14 BASF Aktiengesellschaft Substituted 4-fluoropyridaz-6-ones

Also Published As

Publication number Publication date
DE2254564A1 (en) 1973-05-17
FR2251330B1 (en) 1977-01-14
AU4870872A (en) 1974-05-09
HU164963B (en) 1974-05-28
JPS4856690A (en) 1973-08-09
BE791098A (en) 1973-05-08
DD101675A5 (en) 1973-11-12
NL7214879A (en) 1973-05-14

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