FR2251330A1 - 2-aryl(alkyl)-5-hydrazinopyridazin-3-(2h)-ones - with cns depressant activity - Google Patents
2-aryl(alkyl)-5-hydrazinopyridazin-3-(2h)-ones - with cns depressant activityInfo
- Publication number
- FR2251330A1 FR2251330A1 FR7239439A FR7239439A FR2251330A1 FR 2251330 A1 FR2251330 A1 FR 2251330A1 FR 7239439 A FR7239439 A FR 7239439A FR 7239439 A FR7239439 A FR 7239439A FR 2251330 A1 FR2251330 A1 FR 2251330A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- hydrazinopyridazin
- aryl
- ones
- depressant activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Cpds. of formula (I): (where R1 is H, 1-4C alkyl or 2-4C hydroxyalkyl (not alpha-hydroxyalkyl); R2 is H and R3 is H, 1-4C alkyl or 2-4C alkyl di-, tri- or tetrasubstd. by F or Cl, or NR2R3 is morpholino; R4 and R5 are H, F, Cl, Br, 1-4C alkyl or alkoxy, CF3 or NO2; X is H, F, Cl, or Br; n = 0,1 or 2; with the proviso that (a) >=1 of R1-R5 is other than H; (b) R1 is alkyl when R3 is alkyl; and (c) when R4 and R5 are independently CF3 or t-Bu, they are not no adjacent C atoms) are prepd. by reacting a cpd. (II): (where X' is Cl, F or Br) with R2R3N-NHR1. (I; X = H) are prepd. by catalytic hydrogenation of (I; X = Cl or Br). Cpds. (I) are mild tranquillisers, anticonvulsants and sedatives/hypnotics.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19740171A | 1971-11-10 | 1971-11-10 | |
US22726972A | 1972-02-17 | 1972-02-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2251330A1 true FR2251330A1 (en) | 1975-06-13 |
FR2251330B1 FR2251330B1 (en) | 1977-01-14 |
Family
ID=26892821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7239439A Granted FR2251330A1 (en) | 1971-11-10 | 1972-11-08 | 2-aryl(alkyl)-5-hydrazinopyridazin-3-(2h)-ones - with cns depressant activity |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS4856690A (en) |
AU (1) | AU4870872A (en) |
BE (1) | BE791098A (en) |
DD (1) | DD101675A5 (en) |
DE (1) | DE2254564A1 (en) |
FR (1) | FR2251330A1 (en) |
HU (1) | HU164963B (en) |
NL (1) | NL7214879A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0102510A1 (en) * | 1982-08-06 | 1984-03-14 | BASF Aktiengesellschaft | Substituted 4-fluoropyridaz-6-ones |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU195645B (en) * | 1985-10-30 | 1988-06-28 | Gyogyszerkutato Intezet | Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same |
-
0
- BE BE791098D patent/BE791098A/en unknown
-
1972
- 1972-11-03 NL NL7214879A patent/NL7214879A/xx unknown
- 1972-11-08 HU HUSA002417 patent/HU164963B/hu unknown
- 1972-11-08 JP JP11130372A patent/JPS4856690A/ja active Pending
- 1972-11-08 DE DE19722254564 patent/DE2254564A1/en active Pending
- 1972-11-08 DD DD16673272A patent/DD101675A5/xx unknown
- 1972-11-08 FR FR7239439A patent/FR2251330A1/en active Granted
- 1972-11-09 AU AU48708/72A patent/AU4870872A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0102510A1 (en) * | 1982-08-06 | 1984-03-14 | BASF Aktiengesellschaft | Substituted 4-fluoropyridaz-6-ones |
Also Published As
Publication number | Publication date |
---|---|
DE2254564A1 (en) | 1973-05-17 |
FR2251330B1 (en) | 1977-01-14 |
AU4870872A (en) | 1974-05-09 |
HU164963B (en) | 1974-05-28 |
JPS4856690A (en) | 1973-08-09 |
BE791098A (en) | 1973-05-08 |
DD101675A5 (en) | 1973-11-12 |
NL7214879A (en) | 1973-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR199801197A2 (en) | Phenyl and aminophenyl-alkylsulfonamide and its derivatives. | |
ES423056A1 (en) | Sulphoxides | |
YU172676A (en) | Reactor with radial flow for the synthesis of ammonia,providing high thermic level steam | |
ZA745285B (en) | Catalyst for the oxidation of ammonia | |
FR2251330A1 (en) | 2-aryl(alkyl)-5-hydrazinopyridazin-3-(2h)-ones - with cns depressant activity | |
ES420253A1 (en) | Derivatives of 2-aminoindane thereof | |
ES418891A1 (en) | Amides | |
ES422906A1 (en) | Derivatives of 2-aminoindane, the preparation and use thereof | |
GB1344574A (en) | Aromatic amines | |
ES435622A1 (en) | Benzenesulfonyl ureas and process for their manufacture | |
ES418857A1 (en) | Sulfur-containing ring compounds | |
DE69103838D1 (en) | Detachable container that is designed for internal pressure. | |
ES433221A1 (en) | Quinoxaline compounds as hypnotic agents | |
GB1331548A (en) | Process for preparing fluidized bed catalyst for the production of aromatic nitriles | |
FR2078729A5 (en) | Herbicidal 2,4-bis-trifluoromethyl-6-nitro-anilines | |
ES429768A1 (en) | Nitro-chromeno pyrazole compounds their manufacture and use | |
IE39965B1 (en) | Imidazotriazines | |
ES385924A1 (en) | Benzodioxane derivatives | |
FR2349116A1 (en) | OVEN WITH AIR SUPPLY SYSTEM WITH BURNERS, ESPECIALLY FOR CATALYTIC REFORMING OF HYDROCARBONS | |
GB1374338A (en) | 1,1-dialkyl-2- substituted indazolyl-n1-methyl -hydrazines | |
BE823891A (en) | OXIDATION / AMMOXIDATION CATALYZERS | |
ES384795A1 (en) | Cyclopropane-carboxylic acid benzothiazylamides | |
BE819482A (en) | DEVICE FOR THE REGULATION OF A BURNER | |
ES432926A1 (en) | Derivatives of 1,3-benzodioxole, the preparation and use thereof | |
Wilson | Towards the synthesis of methymycin |