FR2212142A1 - Antimicrobial 1-adamantylamidrazone derivs - prepd. by condensing heterocyclic aldehydes with 1-adamantyl-amidrazone - Google Patents

Antimicrobial 1-adamantylamidrazone derivs - prepd. by condensing heterocyclic aldehydes with 1-adamantyl-amidrazone

Info

Publication number
FR2212142A1
FR2212142A1 FR7345732A FR7345732A FR2212142A1 FR 2212142 A1 FR2212142 A1 FR 2212142A1 FR 7345732 A FR7345732 A FR 7345732A FR 7345732 A FR7345732 A FR 7345732A FR 2212142 A1 FR2212142 A1 FR 2212142A1
Authority
FR
France
Prior art keywords
derivs
prepd
formula
adamantylamidrazone
amidrazone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7345732A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1900072A external-priority patent/CH579047A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2212142A1 publication Critical patent/FR2212142A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70—Nitro radicals
    • C07D307/71—Nitro radicals attached in position 5
    • C07D307/72—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2
    • C07D307/74—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 by hydrazino or hydrazono or such substituted radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Derivs of formula (I): (where X is O, S or N-R which R is lower alkyl or lower hydroxyalkyl; Y is N or =CH; and n is 0,1,2 or 3) and their acid addn salts rare prepd by reacting aldehyde of formula (II) or their acetals of formula (IIa) (where R1 is lower alkyl) with the cpd of formula (III): (I) have trichomonacidal and amoebicidal activity with systemic effect, and are esp. useful in the treatment of trichomonidasis. The y also have an inhibitory effect on bacteria and may additionally be used as antimycotic agents.
FR7345732A 1972-12-28 1973-12-20 Antimicrobial 1-adamantylamidrazone derivs - prepd. by condensing heterocyclic aldehydes with 1-adamantyl-amidrazone Withdrawn FR2212142A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1900072A CH579047A5 (en) 1972-12-28 1972-12-28 Antimicrobial 1-adamantylamidrazone derivs - prepd. by condensing heterocyclic aldehydes with 1-adamantyl-amidrazone
CH1420873 1973-10-04

Publications (1)

Publication Number Publication Date
FR2212142A1 true FR2212142A1 (en) 1974-07-26

Family

ID=25713985

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7345732A Withdrawn FR2212142A1 (en) 1972-12-28 1973-12-20 Antimicrobial 1-adamantylamidrazone derivs - prepd. by condensing heterocyclic aldehydes with 1-adamantyl-amidrazone

Country Status (7)

Country Link
JP (1) JPS4994662A (en)
AU (1) AU6398873A (en)
DD (1) DD109623A5 (en)
DE (1) DE2363817A1 (en)
FR (1) FR2212142A1 (en)
HU (1) HU166633B (en)
NL (1) NL7317565A (en)

Also Published As

Publication number Publication date
JPS4994662A (en) 1974-09-09
HU166633B (en) 1975-04-28
NL7317565A (en) 1974-07-02
AU6398873A (en) 1975-07-03
DD109623A5 (en) 1974-11-12
DE2363817A1 (en) 1974-07-04

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Legal Events

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