FR2212141A1 - Benzophenone amino ether cough suppressants - obtd. from trimethoxyether of chlorobenzophenone by hydrolysis - Google Patents

Benzophenone amino ether cough suppressants - obtd. from trimethoxyether of chlorobenzophenone by hydrolysis

Info

Publication number
FR2212141A1
FR2212141A1 FR7321597A FR7321597A FR2212141A1 FR 2212141 A1 FR2212141 A1 FR 2212141A1 FR 7321597 A FR7321597 A FR 7321597A FR 7321597 A FR7321597 A FR 7321597A FR 2212141 A1 FR2212141 A1 FR 2212141A1
Authority
FR
France
Prior art keywords
obtd
trimethoxyether
chlorobenzophenone
hydrolysis
amino ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7321597A
Other languages
French (fr)
Other versions
FR2212141B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARISTOCHIMICA SpA
Original Assignee
ARISTOCHIMICA SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARISTOCHIMICA SpA filed Critical ARISTOCHIMICA SpA
Publication of FR2212141A1 publication Critical patent/FR2212141A1/en
Application granted granted Critical
Publication of FR2212141B1 publication Critical patent/FR2212141B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(dimeclophenone), is prepd by selective hydrolysis of the trimethoxyether of chlorobenzophenone which is obtd by (a) oxidn. of the carbinol which is itself obtd. by reaction of the Grignard-cpd. of a p-dihalobenzene with 3,4,5-trimethoxybenzaldehyde on (b) reaction of the Grignard-cpd of a p-dihalobenzene with 3,4,5-trimethoxy-benzonitrile, followed by reaction with beta-chloroethylmorpholine.
FR7321597A 1972-12-28 1973-06-14 Benzophenone amino ether cough suppressants - obtd. from trimethoxyether of chlorobenzophenone by hydrolysis Granted FR2212141A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3367072 1972-12-28

Publications (2)

Publication Number Publication Date
FR2212141A1 true FR2212141A1 (en) 1974-07-26
FR2212141B1 FR2212141B1 (en) 1977-01-28

Family

ID=11238047

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7321597A Granted FR2212141A1 (en) 1972-12-28 1973-06-14 Benzophenone amino ether cough suppressants - obtd. from trimethoxyether of chlorobenzophenone by hydrolysis

Country Status (3)

Country Link
CH (1) CH586690A5 (en)
DE (1) DE2321080A1 (en)
FR (1) FR2212141A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521465A2 (en) * 1991-07-01 1993-01-07 Ministero Dell' Universita' E Della Ricerca Scientifica E Tecnologica Anti-fungal benzophenones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521465A2 (en) * 1991-07-01 1993-01-07 Ministero Dell' Universita' E Della Ricerca Scientifica E Tecnologica Anti-fungal benzophenones
EP0521465A3 (en) * 1991-07-01 1993-07-14 Ministero Dell' Universita' E Della Ricerca Scientifica E Tecnologica Anti-fungal benzophenones
US5464836A (en) * 1991-07-01 1995-11-07 Ministero Dell'universita` E Della Ricerca Scientifica E Tecnologica Benzophenones having an antifungal activity

Also Published As

Publication number Publication date
FR2212141B1 (en) 1977-01-28
CH586690A5 (en) 1977-04-15
DE2321080A1 (en) 1974-07-04

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Legal Events

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