FR2207707A1 - 2-Pyrrolidone-5-carboxylic acid esters and amides - with sedative and hypnotic activity - Google Patents
2-Pyrrolidone-5-carboxylic acid esters and amides - with sedative and hypnotic activityInfo
- Publication number
- FR2207707A1 FR2207707A1 FR7242163A FR7242163A FR2207707A1 FR 2207707 A1 FR2207707 A1 FR 2207707A1 FR 7242163 A FR7242163 A FR 7242163A FR 7242163 A FR7242163 A FR 7242163A FR 2207707 A1 FR2207707 A1 FR 2207707A1
- Authority
- FR
- France
- Prior art keywords
- pyrrolidone
- carboxylic acid
- sedative
- amides
- acid esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ODHCTXKNWHHXJC-UHFFFAOYSA-N 5-oxoproline Chemical class OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 230000000147 hypnotic effect Effects 0.000 title 1
- 239000000932 sedative agent Substances 0.000 title 1
- 230000001624 sedative effect Effects 0.000 title 1
- ZBZJXHCVGLJWFG-UHFFFAOYSA-N trichloromethyl(.) Chemical compound Cl[C](Cl)Cl ZBZJXHCVGLJWFG-UHFFFAOYSA-N 0.000 abstract 2
- RMHPSSGICDJKDR-UHFFFAOYSA-N 5-oxopyrrolidine-2-carbonyl chloride Chemical compound ClC(=O)C1CCC(=O)N1 RMHPSSGICDJKDR-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 238000010825 rotarod performance test Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- ROWMQJJMCWDJDT-UHFFFAOYSA-N tribromomethane Chemical compound Br[C](Br)Br ROWMQJJMCWDJDT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7242163A FR2207707A1 (en) | 1972-11-27 | 1972-11-27 | 2-Pyrrolidone-5-carboxylic acid esters and amides - with sedative and hypnotic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7242163A FR2207707A1 (en) | 1972-11-27 | 1972-11-27 | 2-Pyrrolidone-5-carboxylic acid esters and amides - with sedative and hypnotic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2207707A1 true FR2207707A1 (en) | 1974-06-21 |
| FR2207707B1 FR2207707B1 (enExample) | 1975-11-28 |
Family
ID=9107796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7242163A Granted FR2207707A1 (en) | 1972-11-27 | 1972-11-27 | 2-Pyrrolidone-5-carboxylic acid esters and amides - with sedative and hypnotic activity |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2207707A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2270867A1 (enExample) * | 1974-05-14 | 1975-12-12 | Hoechst Ag | |
| EP0314275A3 (en) * | 1987-08-20 | 1991-07-31 | Kissei Pharmaceutical Co., Ltd. | 2-pyrrolidone-5-carboxylic acid compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3051722A (en) * | 1960-10-21 | 1962-08-28 | Lakeside Lab Inc | 5-pyrrolidone-2-carboxamides |
-
1972
- 1972-11-27 FR FR7242163A patent/FR2207707A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3051722A (en) * | 1960-10-21 | 1962-08-28 | Lakeside Lab Inc | 5-pyrrolidone-2-carboxamides |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2270867A1 (enExample) * | 1974-05-14 | 1975-12-12 | Hoechst Ag | |
| EP0314275A3 (en) * | 1987-08-20 | 1991-07-31 | Kissei Pharmaceutical Co., Ltd. | 2-pyrrolidone-5-carboxylic acid compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2207707B1 (enExample) | 1975-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |