FR21C1039I2 - COMPOUNDS FOR THE TREATMENT OF SPINAL TUSKIVE ATROPHY - Google Patents
COMPOUNDS FOR THE TREATMENT OF SPINAL TUSKIVE ATROPHYInfo
- Publication number
- FR21C1039I2 FR21C1039I2 FR21C1039C FR21C1039C FR21C1039I2 FR 21C1039 I2 FR21C1039 I2 FR 21C1039I2 FR 21C1039 C FR21C1039 C FR 21C1039C FR 21C1039 C FR21C1039 C FR 21C1039C FR 21C1039 I2 FR21C1039 I2 FR 21C1039I2
- Authority
- FR
- France
- Prior art keywords
- tuskive
- atrophy
- spinal
- compounds
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993839P | 2014-05-15 | 2014-05-15 | |
| PCT/EP2015/060343 WO2015173181A1 (en) | 2014-05-15 | 2015-05-11 | Compounds for treating spinal muscular atrophy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR21C1039I1 FR21C1039I1 (en) | 2021-10-15 |
| FR21C1039I2 true FR21C1039I2 (en) | 2022-09-02 |
Family
ID=53175048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR21C1039C Active FR21C1039I2 (en) | 2014-05-15 | 2021-09-09 | COMPOUNDS FOR THE TREATMENT OF SPINAL TUSKIVE ATROPHY |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US9969754B2 (en) |
| EP (3) | EP4241772A3 (en) |
| JP (1) | JP6236173B2 (en) |
| KR (2) | KR102213740B1 (en) |
| CN (1) | CN106459092B (en) |
| AR (1) | AR100442A1 (en) |
| AU (1) | AU2015261046C1 (en) |
| CA (1) | CA2948561C (en) |
| CL (1) | CL2016002836A1 (en) |
| CR (1) | CR20160518A (en) |
| DK (1) | DK3143025T3 (en) |
| EA (2) | EA035068B1 (en) |
| ES (2) | ES2761423T3 (en) |
| FR (1) | FR21C1039I2 (en) |
| HR (2) | HRP20230637T1 (en) |
| HU (2) | HUE046491T2 (en) |
| IL (2) | IL248653B (en) |
| LT (1) | LTPA2021010I1 (en) |
| MA (2) | MA51988A (en) |
| MX (1) | MX371050B (en) |
| MY (1) | MY174284A (en) |
| NL (1) | NL301128I2 (en) |
| NO (1) | NO2021035I1 (en) |
| NZ (1) | NZ725008A (en) |
| PE (1) | PE20170128A1 (en) |
| PH (1) | PH12016502081A1 (en) |
| PL (2) | PL3663296T3 (en) |
| PT (1) | PT3143025T (en) |
| RS (1) | RS59718B1 (en) |
| SG (1) | SG11201609497TA (en) |
| SI (2) | SI3663296T1 (en) |
| TW (1) | TWI667239B (en) |
| UA (1) | UA119670C2 (en) |
| WO (1) | WO2015173181A1 (en) |
| ZA (1) | ZA201607026B (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013119916A2 (en) | 2012-02-10 | 2013-08-15 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| MX2016001963A (en) | 2013-08-19 | 2016-05-26 | Hoffmann La Roche | Screening method. |
| US10882868B2 (en) * | 2014-05-15 | 2021-01-05 | Hoffmann-La Roche Inc. | Compounds for treating spinal muscular atrophy |
| JP6749343B2 (en) | 2015-05-20 | 2020-09-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Compounds for treating spinal muscular atrophy |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| BR112018009281B1 (en) * | 2015-11-12 | 2023-10-31 | F. Hoffmann-La Roche Ag | COMPOSITIONS TO TREAT SPINAL MUSCULAR ATROPHY AND THEIR USE |
| CA2996657A1 (en) * | 2015-11-12 | 2017-05-18 | Kathleen Dorothy MCCARTHY | Compounds for treating amyotrophic lateral sclerosis |
| WO2017097728A1 (en) | 2015-12-10 | 2017-06-15 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
| KR102488323B1 (en) | 2015-12-10 | 2023-01-12 | 피티씨 테라퓨틱스, 인크. | Composition for treating or ameliorating Huntington's disease |
| MX2019005588A (en) * | 2016-11-28 | 2019-10-15 | Ptc Therapeutics Inc | Methods for modulating rna splicing. |
| MX2019014514A (en) | 2017-06-05 | 2020-07-20 | Ptc Therapeutics Inc | Compounds for treating huntington's disease. |
| KR20200017476A (en) | 2017-06-14 | 2020-02-18 | 피티씨 테라퓨틱스, 인크. | How to Change RNA Splicing |
| MX2019015578A (en) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Methods for treating huntington's disease. |
| MX2019015580A (en) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Methods for treating huntington's disease. |
| KR20200058468A (en) * | 2017-09-22 | 2020-05-27 | 에프. 호프만-라 로슈 아게 | 7- (4,7-diazaspiro [2.5] octane-7-yl) -2- (2,8-dimethylimidazo [1,2-b] pyridazine-6-yl) pyrido [1 , 2-a] Preparation method of pyrimidin-4-one derivative |
| EP3691647A1 (en) * | 2017-10-03 | 2020-08-12 | H. Hoffnabb-La Roche Ag | New treatment of sma |
| WO2019191092A1 (en) | 2018-03-27 | 2019-10-03 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| KR20210042265A (en) | 2018-06-27 | 2021-04-19 | 피티씨 테라퓨틱스, 인크. | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
| EP3814360A1 (en) | 2018-06-27 | 2021-05-05 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| CA3116458C (en) | 2018-10-19 | 2023-12-12 | F. Hoffmann-La Roche Ag | New forms of pyrido[1,2-a]pyrimidin-4-one derivatives, its formulation and its process of making |
| WO2020249577A1 (en) | 2019-06-12 | 2020-12-17 | F. Hoffmann-La Roche Ag | New treatment of sma |
| US20220315607A1 (en) | 2019-07-31 | 2022-10-06 | Teva Pharmaceuticals International Gmbh | Solid state forms of risdiplam and process for preparation thereof |
| WO2022048675A1 (en) * | 2020-09-07 | 2022-03-10 | 苏州科睿思制药有限公司 | Crystal form of risdiplam, preparation method therefor, and use thereof |
| WO2022162107A1 (en) | 2021-02-01 | 2022-08-04 | Sandoz Ag | Crystalline form of risdiplam |
| CN116981673A (en) * | 2021-03-17 | 2023-10-31 | 豪夫迈·罗氏有限公司 | Novel thiadiazolopyrimidinone derivatives |
| CA3212341A1 (en) | 2021-03-17 | 2022-09-22 | F. Hoffmann-La Roche Ag | New thiazolopyrimidinone derivatives |
| CN117015546A (en) | 2021-03-18 | 2023-11-07 | 豪夫迈·罗氏有限公司 | Process for preparing Li Sipu blue |
| WO2023057404A1 (en) | 2021-10-06 | 2023-04-13 | F. Hoffmann-La Roche Ag | Novel combined administration |
| WO2023202501A1 (en) * | 2022-04-18 | 2023-10-26 | 深圳市塔吉瑞生物医药有限公司 | Substituted pyridopyrimidinone compound, composition comprising same, and use thereof |
| WO2023240236A1 (en) | 2022-06-10 | 2023-12-14 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of spinal muscular atrophy related disorders |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998005661A1 (en) * | 1996-08-06 | 1998-02-12 | Pfizer Inc. | Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives |
| CA2700841A1 (en) | 2007-09-27 | 2009-04-02 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| WO2009151546A2 (en) * | 2008-05-27 | 2009-12-17 | Ptc Therapeutics, Inc. | Methods for treating spinal muscular atrophy |
| KR20100012134A (en) * | 2008-07-28 | 2010-02-08 | 신호열 | A mouse for notebook-pc |
| US8932818B2 (en) | 2008-08-13 | 2015-01-13 | Ptc Therapeutics, Inc. | Screening assays for compounds that modulate programmed ribosomal frameshifting |
| EP2337609B1 (en) * | 2008-08-14 | 2016-08-17 | Cardiac Pacemakers, Inc. | Performance assessment and adaptation of an acoustic communication link |
| US9617268B2 (en) * | 2011-12-30 | 2017-04-11 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| WO2013119916A2 (en) * | 2012-02-10 | 2013-08-15 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| US9212209B2 (en) | 2012-07-13 | 2015-12-15 | Indiana University Research And Technology Corporation | Screening methods for spinal muscular atrophy |
| BR112018009281B1 (en) | 2015-11-12 | 2023-10-31 | F. Hoffmann-La Roche Ag | COMPOSITIONS TO TREAT SPINAL MUSCULAR ATROPHY AND THEIR USE |
-
2015
- 2015-05-11 PL PL19200058.6T patent/PL3663296T3/en unknown
- 2015-05-11 JP JP2016567816A patent/JP6236173B2/en active Active
- 2015-05-11 WO PCT/EP2015/060343 patent/WO2015173181A1/en active Application Filing
- 2015-05-11 MA MA051988A patent/MA51988A/en unknown
- 2015-05-11 AU AU2015261046A patent/AU2015261046C1/en active Active
- 2015-05-11 KR KR1020167034983A patent/KR102213740B1/en active IP Right Grant
- 2015-05-11 SI SI201531952T patent/SI3663296T1/en unknown
- 2015-05-11 MY MYPI2016001903A patent/MY174284A/en unknown
- 2015-05-11 NZ NZ72500815A patent/NZ725008A/en unknown
- 2015-05-11 PL PL15721701T patent/PL3143025T3/en unknown
- 2015-05-11 CN CN201580027306.9A patent/CN106459092B/en active Active
- 2015-05-11 PT PT157217019T patent/PT3143025T/en unknown
- 2015-05-11 EP EP23169721.0A patent/EP4241772A3/en active Pending
- 2015-05-11 ES ES15721701T patent/ES2761423T3/en active Active
- 2015-05-11 HR HRP20230637TT patent/HRP20230637T1/en unknown
- 2015-05-11 UA UAA201612716A patent/UA119670C2/en unknown
- 2015-05-11 EA EA201692280A patent/EA035068B1/en active Protection Beyond IP Right Term
- 2015-05-11 KR KR1020217002966A patent/KR102256013B1/en active IP Right Grant
- 2015-05-11 EP EP15721701.9A patent/EP3143025B1/en active Active
- 2015-05-11 SI SI201531021T patent/SI3143025T1/en unknown
- 2015-05-11 DK DK15721701T patent/DK3143025T3/en active
- 2015-05-11 CA CA2948561A patent/CA2948561C/en active Active
- 2015-05-11 CR CR20160518A patent/CR20160518A/en unknown
- 2015-05-11 MA MA39995A patent/MA39995B1/en unknown
- 2015-05-11 EA EA202090486A patent/EA202090486A3/en unknown
- 2015-05-11 SG SG11201609497TA patent/SG11201609497TA/en unknown
- 2015-05-11 MX MX2016014547A patent/MX371050B/en active IP Right Grant
- 2015-05-11 PE PE2016002128A patent/PE20170128A1/en unknown
- 2015-05-11 ES ES19200058T patent/ES2949660T3/en active Active
- 2015-05-11 HU HUE15721701A patent/HUE046491T2/en unknown
- 2015-05-11 RS RS20191541A patent/RS59718B1/en unknown
- 2015-05-11 EP EP19200058.6A patent/EP3663296B1/en active Active
- 2015-05-14 TW TW104115433A patent/TWI667239B/en active
- 2015-05-14 AR ARP150101500A patent/AR100442A1/en not_active Application Discontinuation
-
2016
- 2016-10-12 ZA ZA2016/07026A patent/ZA201607026B/en unknown
- 2016-10-19 PH PH12016502081A patent/PH12016502081A1/en unknown
- 2016-10-31 IL IL24865316A patent/IL248653B/en active IP Right Grant
- 2016-11-08 CL CL2016002836A patent/CL2016002836A1/en unknown
- 2016-11-14 US US15/351,267 patent/US9969754B2/en active Active
-
2019
- 2019-10-17 IL IL270027A patent/IL270027B/en active IP Right Grant
- 2019-11-29 HR HRP20192159TT patent/HRP20192159T1/en unknown
-
2021
- 2021-09-09 FR FR21C1039C patent/FR21C1039I2/en active Active
- 2021-09-10 NO NO2021035C patent/NO2021035I1/en unknown
- 2021-09-14 HU HUS2100037C patent/HUS2100037I1/en unknown
- 2021-09-14 LT LTPA2021010C patent/LTPA2021010I1/lt unknown
- 2021-09-15 NL NL301128C patent/NL301128I2/en unknown
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