FR2189058A1 - S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors - Google Patents
S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitorsInfo
- Publication number
- FR2189058A1 FR2189058A1 FR7322316A FR7322316A FR2189058A1 FR 2189058 A1 FR2189058 A1 FR 2189058A1 FR 7322316 A FR7322316 A FR 7322316A FR 7322316 A FR7322316 A FR 7322316A FR 2189058 A1 FR2189058 A1 FR 2189058A1
- Authority
- FR
- France
- Prior art keywords
- substd
- thioadenosines
- platelet aggregation
- blood platelet
- aggregation inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cpds. (I) and their 51-monophosphates- (where R is alkyl, cycloalkyl, cycloalkyl-alkyl, each of 5 or more C atoms, opt. substd. allyl, opt. substd. benzyl or dialkylaminoalkyl), are prepd. by reacting 2-thioadenosine with R.Halide and opt. phosphorylating the prodt. Thus (I; R = PhCH2) is prepd. by reacting 2-thioadenosine with PhCH2Br in the presence of NaOH.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP47060464A JPS5216120B2 (en) | 1972-06-19 | 1972-06-19 | |
JP12961972A JPS4986392A (en) | 1972-12-26 | 1972-12-26 | |
JP12962072A JPS4986393A (en) | 1972-12-26 | 1972-12-26 | |
JP48011159A JPS5238040B2 (en) | 1973-01-29 | 1973-01-29 | |
JP2798573A JPS49110694A (en) | 1973-03-12 | 1973-03-12 | |
JP3270373A JPS544959B2 (en) | 1973-03-23 | 1973-03-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2189058A1 true FR2189058A1 (en) | 1974-01-25 |
FR2189058B1 FR2189058B1 (en) | 1976-10-22 |
Family
ID=27548319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7322316A Granted FR2189058A1 (en) | 1972-06-19 | 1973-06-19 | S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2189058A1 (en) |
SE (1) | SE401679B (en) |
-
1973
- 1973-06-18 SE SE7308560A patent/SE401679B/en unknown
- 1973-06-19 FR FR7322316A patent/FR2189058A1/en active Granted
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS 59 (1962) 1742C cite CHEM. PHARM. BULL. (TOKYO) 10, pages 647 - 652 * |
Also Published As
Publication number | Publication date |
---|---|
SE401679B (en) | 1978-05-22 |
FR2189058B1 (en) | 1976-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |